Pulmonary responses to in haled para-aramid fibrils in hamsters: Evidence of biodegradability in the lungs of a second rodent species

Inhalation Toxicology

Volumn 9, Issue 2, 1997, Pages 181-187

  Warheit, D B ^a   Snajdr, S I ^a   Hartsky, M A ^a   Frame, S R ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030902807     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. European Centre for Ecotoxicology and Toxicology of Chemicals. 1996, Toxicology of Man-Made Organic Fibres. Tech. Rep. 69. April. Brussels: ECETOC.
2. Kelly, D. P., Merriman, E. A., Kennedy, G. L., Jr., and Lee, K. P. 1993. Deposition, clearance and shortening of Kevlar para-aramid fibrils in acute, subchronic and chronic inhalation studies in rats. Fundam. Appl. Toxicol. 21:345-354.
3. Searl, A. 1996. A comparative study of the clearance of respirable para-aramid, chrysotile and glass fibres from rat lungs. Ann. Occup. Hyg., in press.
4. Warheit, D. B., Kellar, K. A., and Hartsky, M. A. 1992. Pulmonary cellular effects in rats following aerosol exposures to ultrafine Kevlar aramid fibrils: Evidence for biodegradability of inhaled fibrils. Toxicol. Appl. Pharmacol. 116:225-239.
5. Warheit, D. B., Hartsky, M. A., Butterick, C. J., and Frame, S. R. 1995. Pulmonary toxicity studies with man-made organic fibres: Preparation and comparisons of size-separated paraaramid with chrysotile asbestos fibres. In Toxicology of industrial compounds, eds. H. Thomas, R. Hess, and F. Waechter, pp. 119-130. London: Taylor & Francis.
6. Warheit, D. B., Hartsky, M. A., and Frame, S. R. 1996. Pulmonary effects in rats inhaling size-separated chrysotile asbestos fibres or p-aramid fibrils: Differences in cellular proliferative responses. Toxicol. Lett. 88:287-292.