Effects of non-conservative changes to tyrosine 76, a key DNA binding residue of DNase I, on phosphodiester bond cleavage and DNA hydrolysis selectivity

Protein Engineering

Volumn 10, Issue 3, 1997, Pages 279-283

  Warren, Mark A ^a   Evans, Steven J ^a   Connolly, Bernard A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

DNA hydrolysis; DNase I; Site directed mutagenesis

Indexed keywords

DEOXYRIBONUCLEASE I; DNA; DNA FRAGMENT; THYMIDINE DIPHOSPHATE; TYROSINE;

ARTICLE; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; HYDROGEN BOND; HYDROLYSIS; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING;

ESCHERICHIA COLI;

EID: 0030902167     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/10.3.279     Document Type: Article

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