Linkage mapping in experimental crosses: The robustness of single-gene models

Genetics

Volumn 146, Issue 1, 1997, Pages 417-425

  Wright, Fred A ^a   Kong, Augustine ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREEDING; GENE MAPPING; GENETIC LINKAGE; GENETIC MODEL; MARKER GENE; PRIORITY JOURNAL;

CROSSES, GENETIC; GENETIC MARKERS; LINKAGE (GENETICS); MODELS, GENETIC;

EID: 0030902117     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. CHURCHILL, G. A., and R. W. DOERGE, 1994 Mapping Quantitative Trait Loci in Experimental Populations. Cornell University Biometrics Technical Report BU-1238-M, Ithaca, NY.
2. CLERGET-DARPOUX, F., C. BONAITI-PELLIÉ and J. HOCHEZ, 1986 Effects of misspecifying genetic parameters in LOD score analysis. Biometrics 42: 393-399.
3. Cox, D. R., and D. V. HINKLEY, 1974 Theoretical Statistics. Chapman and Hall, London.
4. DAVARSI, A., A. WEINREB, V. MNIKE, J. I. WELLER and M. SOLLER, 1993 Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 134: 943-951.
5. HALEY, C. S., and S. A. KNOTT, 1992 A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Genetics 69: 315-324.
6. HODGE, S. E., and R. C. ELSTON, 1994 Lods, wrods, and mods: the interpretation of lod scores calculated under different models. Genet. Epidemiol. 11: 329-342.
7. HUBER, P. J., 1967 The behavior of maximum likelihood estimates under nonstandard conditions. Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability. University of California Press, Vol. 1, 221-233.
8. JACOB, H. J., K. LINDPAINTNER, S. E. LINCOLN, K. KUSUMI, R. K. BUNKER, et al., 1991 Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67: 213-224.
9. JANSEN, R. C., 1993 Interval mapping of multiple quantitative trait loci. Genetics 35: 205-211.
10. KENDALL, M., A. STUART and J. K. ORD, 1987 The Advanced Theory of Statistics, Vol. 1. Griffin, London.
11. KONG, A., and F. WRIGHT, 1994 Asymptotic theory for gene mapping. Proc. Natl. Acad. Sci. USA 91: 9705-9709.
12. KRUGLYAK, L., and E. S. LANDER, 1995 High-resolution genetic mapping of complex traits. American Journal of Human Genetics 56: 1212-1223.
13. LANDER, E. S., and D. BOTSTEIN, 1989 Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.
14. MARTINEZ, O., and R. N. CURNOW, 1992 Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers. Theoret. Appl. Genet. 85: 480-488.
15. MCCULLAGH, P., and J. A. NELDER, 1989 Generalized Linear Models, Ed. 2. University Press, Cambridge.
16. OTT, J., 1991 Analysis of Human Genetic Linkage. Johns Hopkins University Press, Baltimore, MD.
17. PATERSON, A. H., E. S. LANDER, J. HEWITT, S. PETERSON, and S. D. TANKSLEY, 1988 Resolution of quantitative traits into Mendelian factors using a complete RFLP linkage map. Nature 335: 721-726.
18. RISCH, N., and L. GIUFFRA, 1992 Model misspecification and multipoint linkage analysis. Human Hered. 42: 77-92.
19. VIELAND, V. J., S. E. HODGE, and D. A. GREENBERG, 1992 Adequacy of single-locus approximations for linkage analyses of oligogenic traits. Genet. Epidemiol. 9: 45-59.
20. WILLIAMSON, J. A., and C. I. AMOS, 1990 On the asymptotic behavior of the estimate of the recombination fraction under the null hypothesis of no linkage when the model is misspecified. Genet. Epidemiol. 7: 309-318.
21. WILLIAMSON, J. A., and C. I. AMOS, 1995 Guess LOD approach: sufficient conditions for robustness. Genet. Epidemiol. 12: 163-176.
22. WRIGHT, F. A., and A. KONG, 1995 Robustness of Single-Gene Models: Backcross and Doubled Haploid Populations. Technical Report No. 369, Department of Statistics, The University of Chicago, IL.