SmI2-mediated reductive enolization of α-hetero-substituted ketones and enantioselective protonation

Tetrahedron Letters

Volumn 38, Issue 15, 1997, Pages 2709-2712

  Nakamura, Yutaka ^a   Takeuchi, Seiji ^a   Ohgo, Yoshiaki ^a   Yamaoka, Makoto ^b   Yoshida, Akihiro ^b   Mikami, Koichi ^b  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXANONE DERIVATIVE; KETONE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030901984     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00435-8     Document Type: Article

References (19)

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18. 3 and 4 were synthesized by the reaction of (R)- and (S)-1,1′-bi-2-naphthol with (S)-1-phenyl-2-[(p-toluenesulfonyl)oxy]-1-(tetrahydropyranyloxy)ethane and (R)-1-(o-chlorophenyl)-2-[(p-toluenesulfonyl)-oxy]-1-(tetrahydropyranyloxy) ethane which were prepared from (S)-mandelic acid and (R)-o-chloromandelic acid, respectively. Full experimental details will be published elsewhere.
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