Gastric mucosal injury by nonsteroidal anti-inflammatory drugs is reduced by (R)-α-methylhistamine and its pro-drugs in the rat

Inflammation Research

Volumn 46, Issue 1, 1997, Pages

  Morini, G ^a   Grandi, D ^a   Krause, M ^b   Schunack, W ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA METHYLHISTAMINE; INDOMETACIN MEGLUMINE; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; STOMACH HEMORRHAGE; STOMACH MUCOSA LESION; STOMACH ULCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; GASTRIC ACID; GASTRIC MUCOSA; HISTAMINE AGONISTS; INDOMETHACIN; MALE; METHYLHISTAMINES; PRODRUGS; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 0030901965     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990;259:G462-7.
2. Wallace JL, Granger DN. Pathogenesis of NSAID gastropathy: are neutrophils the culprits? Trends Pharmacol Sci 1992; 13:129-31.
3. 3-receptors. Nature 1987;327:117-23.
4. 3 receptors? Digestion 1995;56:145-52.
5. 3 receptor agonists. J Med Chem 1995;38: 4070-9.
6. Holzer P, Lippe IT. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 1988;27:981-7.
7. Morini G, Grandi D, Bertaccini G. Stimulation of gastric acid secretion by (R)-α-methylhistamine in the rat: influence of the increased gastric juice volume on ethanol-induced lesions. Inflamm Res 1995;44:S106-7.