Modulation of cytochrome P450 by 5,5'-bis-trifluoromethyl-2,2'-dichlorobiphenyl a unique environmental contaminant

Toxicology

Volumn 120, Issue 3, 1997, Pages 197-205

  Drahushuk, Adam T ^a   Choy, Chik O ^b   Kumar, Subodh ^c   McReynolds, James H ^a   Olson, James R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c BUFFALO STATE COLLEGE   (United States)

Author keywords

5,5' bis trifluoromethyl 2,2' dichlorobiphenyl; CYP1A1; CYP1A2; CYP2B1; CYP2B2; Cytochrome P450

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; ENVIRONMENTAL CHEMICAL; PHENOBARBITAL; POLYCHLORINATED BIPHENYL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; LIVER MICROSOME; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEDIMENT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; BODY WEIGHT; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; MALE; MICROSOMES, LIVER; ORGAN SIZE; POLYCHLORINATED BIPHENYLS; RATS; RATS, WISTAR; STEROID HYDROXYLASES; TETRACHLORODIBENZODIOXIN;

ANIMALIA; RATTUS NORVEGICUS; ZEA MAYS;

EID: 0030901856     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)00056-5     Document Type: Article

References (36)

1. Ahlborg, U.G., Brouwer, A., Fingerhut, M.A., Jacobson, J.L., Jacobson, S.W., Kennedy, S.W., Keftrup, A.A.F., Koeman, J.H., Poiger, H., Rappe, C., Safe, S.H., Seegal, R.F., Tuomisto, J. and Van de Berg, M. (1992) Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls, on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Sect. 228, 179-199.
2. Albro, P.W. and Mckinney, J.D. (1981) The relationship between polarizability of polychlorinated biphenyls and their induction of mixed function oxidase activity. Chem.-Biol. Interact. 34, 373-378.
3. Bandiera, S., Sawyer, T., Romkes, M., Zmudska, B., Safe, L., Mason, G., Keys, B. and Safe, S. (1984) Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology 32, 131-144.
4. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Buchmann, A., Ziegler, S., Wolf, A., Robertson, L.W., Durham, S.K. and Schwarz, M. (1991) Effects of polychlorinated biphenyls in rat liver: correlation between primary subcellular effects and promoting activity. Toxicol. Appl. Pharmacol. 111, 454-468.
6. De Haan, L.H.J., Halfwerk, S., Hovens, S.E.L., De Roos, B., Koeman, J.H. and Brouwer, A. (1996) Inhibition of intracellular communication and induction of ethoxyresorufin-O-deethylase activity by polychlorobiphenyls, dibenzo-p-dioxins and dibenzofurans in mouse hepalclc7 cells. Environ. Toxicol. Pharmacol. 1, 27-37.
7. Elder, V.A., Proctor, B.L. and Hites, R.A. (1981) Organic compounds found near dump sites in Niagara Falls, New York. Environ. Sci. Technol. 15, 1237-1243.
8. Goldstein, J.A., Hickman, P., Bergman, H., Mckinney, J.D. and Walker, M.P. (1977) Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P450 or P448. Chem.-Biol. Interact. 17, 69-87.
9. Ikegwuonu, F.I., Ganem, L.G., Larsen, M.C., Shen, X. and Jefcoate, C.R. (1996) The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2′,4′,5′-hexachlorobiphenyl. Toxicol. Appl. Pharmacol. 139, 33-41.
10. Jaffe, R. and Hites, R.A. (1985) Identification of new, fluorinated biphenyls in the Niagara River-Lake Ontario area. Environ. Sci. Technol. 19, 736-740.
11. Jaffe, R. and Hites, R.A. (1986) Fate of hazardous waste derived organic compounds in Lake Ontario. Environ. Sci. Technol. 20, 267-274.
12. Kittner, B., Brautigam, M. and Herken, H. (1987) PC12 cells: a model system for studying drug effects on dopamine synthesis and release. Arch. Int. Pharmacodyn. Ther. 286, 181-194.
13. Kuratsune, M., Yoshimura, T., Matsuzaka, J. and Ymasuchi, A. (1972) Epidemiologic study on Yusho, a poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls. Environ. Health Perspect. 1, 119-128.
14. Lake, B.G., Phillips, J.C., Harris, R.A. and Gangolli, S.D. (1979) The effect of ammonium sulfate on the metabolism of dimethylnitrosamine and other xenobiotics by rat hepatic microsomes. Drug Metab. Dispos. 7, 181-187.
15. Laemmli, U.K., (1970) Change of the structural protein during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
16. Liu, G., Gelboin, H.V. and Myers, M.J. (1991) Role of cytochrome P4501A2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies. Arch. Biochem. Biophys. 284, 400-406.
17. Lu, A.Y.H., Levin, W., West, S.B., Jacobson, M., Ryan, D., Kuntzman, R. and Conney, A.H. (1973) Reconstituted liver microsomal enzyme system that hydroyxlates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats. J. Biol. Chem. 248, 456-460.
18. Mason, G., Sawyer, T., Keys, B., Bandiera, M., Romkes, M., Piskorska-Pliszczynska, B., Zmudzka, B. and Safe, S. (1985) Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships. Toxicology 37, 1-12.
19. Mason, G., Farrell, K., Keys, B., Piskorska-Pliszczynska, J., Safe, L. and Safe, S. (1986) Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships. Toxicology 41, 21-31.
20. Murai, Y. and Kuroiwa, Y. (1971) Peripheral neuropathy in chlorobiphenyl poisoning. Neurology 21, 1173-1176.
21. Nash, T. (1953) The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55, 416-421.
22. Omura, T. and Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem. 239, 2370-2378.
23. Parkinson, A., Robertson, L.W., Safe, L. and Safe, S. (1981) Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution. Chem.-Biol. Interact. 35, 1-12.
24. Poland, A. and Knutson, J.C. (1982) 2,3,7,8-tetrachloro-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517 554.
25. Prough, R.A., Burke, M.D. and Mayer, R.T. (1978) Direct fluorometric methods for measuring mixed function oxidase activity. Methods Enzymol. 52, 372-377.
26. Safe, S. (1984) Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit. Rev. Toxicol. 13, 319-395.
27. Safe, S. (1986) Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26, 371-399.
28. Safe, S. (1990) Polychlorinated biphenyls (PCBs). dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). CRC Crit. Rev. Toxicol. 21, 51-88.
29. Seegal, R.F., Bush, B. and Shain, W. (1990) Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture. Toxicol. Appl. Pharmacol. 106, 136-144.
30. Shain, W., Bush, B. and Seegal, R. (1991) Neurotoxicity of polychlorinated biphenyls: structure-activity relationship of individual congeners. Toxicol. Appl. Pharmacol. 111, 33-42.
31. Shimada, T., Yun, C.H., Yamazaki, H., Gautier, J.C., Beaune, P.H. and Guengerich, P.P. (1992) Characterization of human lung microsomal cytochrome P4501A1 and its role in the oxidation of chemical carcinogens. Mol. Pharmacol. 41, 856-864.
32. Tsyrlov, I.B. and Duzchak, T.G. (1990) Interspecies features of hepatic cytochromes P4501A1 and P4501A2 in rodents. Xenobiotica 20, 1163-1170.
33. Van den Berg, M., De Jongh, J., Poiger, H. and Olson, J.R. (1994) The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit. Rev. Toxicol. 24, 1-74.
34. Vanden Heuvel, J.P. and Lucier, G. (1993) Environmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans. Environ. Health Perspect. 100, 189-200.
35. Wroblewski, V.J., Gessner, T. and Olson, J.R. (1988) Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster. Biochem. Pharmacol. 37, 1509-1517.
36. Yoshimura, H., Yoshihara, S., Ozawa, N. and Miki, M. (1979) Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats. Ann. NY Acad. Sci. 320, 179-192.