The uptake of a monoclonal antibody (Po66) in lung tumour cell aggregates involves a phagocytose-like phenomenon

International Journal of Oncology

Volumn 10, Issue 3, 1997, Pages 609-613

  Dazord, Léontine ^a   Thomas, Daniel ^b   Brichory, Franck ^a   Cavalier, Annie ^b   Meritte, Hélène ^a   Desrues, Benoit ^c   Caulet Maugendre, Sylvie ^d   Bourguet, Patrick ^a  

^a Ctr Reg de Lutte Contre le Cancer   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^d RENNES UNIVERSITY HOSPITAL   (France)

Author keywords

autoradiography; dosimetry; lung squamous carcinoma; monoclonal antibody; multicellular spheroids; transmission electron microscopy

Indexed keywords

IODINE 125; MONOCLONAL ANTIBODY;

ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG UPTAKE; HUMAN; HUMAN CELL; LUNG CARCINOMA; PHAGOCYTOSIS; PRIORITY JOURNAL; TUMOR SPHEROID;

EID: 0030901687     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.10.3.609     Document Type: Article

References (23)

1. Humm JL: Dosimctric aspects of radiolabeled antibodies for tumor therapy. J Nucl Med 27: 1490-1497, 1986.
2. Wilder RB, DeNardo GL and DeNardo SJ: Radioimmunotherapy: recent results and future directions. J Clin Oncol 14: 1383-1400, 1996.
3. Ychou M, Ricard M, Lumbroso J, Rougier P, Mach JP, Buchegger F, Saccavini JC, Lasser P, Elias D, Eschwege F and Parmentier C: Potential contribution of 1311-labelled monoclonal anti-CEA antibodies in the treatment of liver metastases from colorectal carcinomas: pretherapeutic study with dose recevery in resected tissues. Eur J Cancer 29A: 1105-1111, 1993.
4. Begent RHJ, Ledermann JA, Green AJ, Bagshawe KD, Riggs SJ, Searle F, Keep PA, Adam T, Dale RG and Glaser MG: Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for coloreetal cancer. Br J Cancer 60: 406-412, 1989.
5. Rak J, Mitsuhashi Y, Erdos V, Huang SN, Filmus J and Kerbel RS: Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression. J Cell Biol 131: 1587-1598, 1995.
6. Griffon G, Marchal C, Merlin JL, Marchai S, Parache RM and Bey P: Radiosensitivity of multicellular tumour spheroids obtained from human ovarian cancers. Eur J Cancer 31A: 85-91, 1995.
7. Dazord L, Bourel D, Martin A, Lecorre R, Bourguet P, Bohy J, Saccavini JC, Delaval P, Louvct M and Toujas L: A monoclonal antibody (Po66) directed against human lung squamous cell carcinoma: Immunolocalization of tumour xenografts in nude mice. Cancer Immunol Immunother 24: 263-268, 1987.
8. Martin A, Pellen P, Guitton C, Youinou P, Collet B, Desrues B, Bourel D, Dazord L and Toujas L: Characterization of the antigen identified by Po66: A monoclonal antibody raised against a lung squamous cell carcinoma. Cancer Immunol Immunother 29: 118-124, 1989.
9. Brichory F, Collet B, Pineau C, Desrues B, Toujas L, Le Pennee JP and Dazord L: Purification of a tumoral marker recognized by monoclonal antibody Po66 and associated with human lung squamous cell carcinoma. Int J Biol Markers 11: 148-152, 1996.
10. Dazord L, Cavalier A, Thomas D, Guiraud JM, Le Lannic J, Robin V, Collet B, Desrues B, Ramée MP and Toujas L: Uptake and release of radiolabelled monoclonal antibody Po66 by multicellular aggregates obtained from a lung squamous carcinoma cell line. Anticancer Res 13: 451-458, 1993.
11. Thomas D, Cavalier A and Gouranton J: Dynamic study of nucleic acids by autoradiography. In: Visualization of Nucleic Acids. Morel G (ed.) Boca Raton, FL, CRC Press pp155-168, 1995.
12. Freeman AE and Huffman RM: In vivo-like growth of human tumors in vitro. Rad Oncol Biol Phys 23: 69-80, 1992.
13. Walker KA, Mairs R, Murray T, Hilditch TE, Wheldon TE, Gregor A and Hann IM: Tumor spheroid model for the biologically targeted radiotherapy of neuroblastoma micromctastascs. Cancer Res 50: 1000s-1002s, 1990.
14. 131I-labeled TNT-I radioimmunortherapy on HT-29 human colon adenocarcinoma spheroids. Cancer Immunol Immunother 33: 158-164, 1991.
15. Haji-Karim M and Carlsson J: proliferation and viability in cellular spheroids of human origin. Cancer Res 38: 1457-1464, 1978.
16. Schwachöfer JHM, Crooijmans RMA, Hoogenhout J, Jerusalem CR, Kal HB and Theeuwes AGM: Radiosensitivily of different human tumor cell lines grown as multicellular spheroids derived from growth curves and survival data. Int J Radiat Oncol Biol Phys 17: 1015-1020, 1989.
17. Langmuir VK, McGann JK, Buchegger F and Sutherland RM: The effect of antigen concentration, antibody valency and size, and tumor architecture on antibody binding in multicell spheroids. Nucl Med Biol 18: 753-764, 1991.
18. Chcn FM, Epstein AL, Li Z and Taylor CR: A comparative autoradiographic study demonstrating differential intratumor localization of monoclonal antibodies to cell surface (lym-1) and intracellular (TNT-I) antigens. J Nucl Med 31: 1059-1066, 1990.
19. 125I-antibody therapy efficacy in multicell spheroids. Cancer Res 57: 4728-4734, 1992.
20. Desrues B, Léna H, Brichory F, Ramée MP, Toujas L, Delaval P and Dazord L: Monoclonal antibody Po66 uptake by human lung tumours implanted in nude mice: effect of co-administration with doxorubicin. Br J Cancer 72: 1076-1082, 1995.
21. Jonkhoff AR, Huijens PC, Versteegh RT, van Dieren EB, Ossenkoppele GJ, Martens HJ and Teule GJ: Gallium-67 radiotoxicity in human U937 lymphoma cells. Br J Cancer 67: 693-700, 1993.
22. Hou DY, Maruyama Y and Drago JR: Chromosome aberrations of human small cell lung cancer induced by a new 111 Inbleomycin complex. J Surg Oncol 51: 236-242, 1992.
23. Rotmensch J, Schwartz JL, Atcher RW, Harper PV and De Sombre E: Increased nuclear damage by high linear energy transfer radioisotopes applicable for radiodirectcd therapy against radiologie malignancies. Gynecol Obstet Invest 32: 180-184, 1991.