Δ9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus

European Journal of Pharmacology

Volumn 323, Issue 2-3, 1997, Pages 193-195

  Corchero, Javier ^a   Fuentes, Jose A ^a   Manzanares, Jorge ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

9 Tetrahydrocannabinol; Arcuate nucleus; mRNA; Opioid; Proopiomelanocortin

Indexed keywords

DRONABINOL; MESSENGER RNA; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPOPHYSIS; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARCUATE NUCLEUS; GENE EXPRESSION; HALLUCINOGENS; HISTOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; PITUITARY GLAND, ANTERIOR; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; STIMULATION, CHEMICAL; TETRAHYDROCANNABINOL;

EID: 0030901502     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00144-1     Document Type: Article

References (13)

1. Chronwall, M.B., 1985. Anatomy and physiology of the neuroendocrine arcuate nucleus. Peptides 6, 1-11.
2. Dewey, W.L., 1986. Cannabinoid pharmacology. Pharmacol. Rev. 38, 151-178.
3. Eipper, B.A., Mains, R.E., 1980. Structure and biosynthesis of proadrenocorticotropin/endorphin and related peptides. Endocr. Rev. 1, 1-27.
4. Emerson, R.B., Eipper, B.A., 1986. Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. J. Neurosci. 6, 837-849.
5. Gramsch, C., Kleber, G., Höllt, V., Pasi, A., Mehracin, P., Herz, A., 1980. Proopiocortin fragments in human and rat brain: β-endorphin and α-MSH are the predominant peptides. Brain Res. 192, 109-119.
6. Kaymakcalan, S., Ayhan, I.H., Tulinay, F.C., 1977. Naloxone-induced or postwithdrawal abstinence signs in tolerant rats. Psychopharmacology 55, 243-249.
7. 9-Tetrahydrocannabinol regulates substance P and enkephalin mRNAs levels in the caudate-putamen. Eur. J. Pharmacol. 267, R1-R3.
8. Mailleux, P., Verslype, M., Preud'homme, X., Vanderhaeghen, J.J., 1994. Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain. NeuroReport 5, 1265-1268.
9. Pert, A., Pert, C.B., Davis, G.C., Bunney Jr., W.E., 1981. Opiate peptides and brain function. In: Van Praag, H.M. (Ed.), Handbook of Biological Psychiatry. Part IV: Brain Mechanisms and Abnormal Behavior. Chemistry, New York, NY, pp. 547-582.
10. 9-tetrahydrocannabinol-induced analgesia in mice. Eur. J. Pharmacol. 301, 75-81.
11. Vaysse, P.J.J., Gardner, E.L., Zukin, R.S., 1987. Modulation of rat brain opioid receptors by cannabinoids. J. Pharmacol. Exp. Ther. 241, 534-539.
12. Vela, G., Ruiz-Gayo, M., Fuentes, J.A., 1995. Anandamide decreases naloxone-precipitated withdrawal signs in mice chronically treated with morphine. Neuropharmacology 34, 665-668.
13. Young, W.S., Mezey, E., Siegel, R.E., 1986. Quantitative in situ hybridization histochemistry reveals increase levels of corticotropin-releasing factor mRNA after adrenalectomy in rats. Neurosci. Lett. 70, 198-203.