Analysis of the metabolites of [I-123]β-CIT in plasma of human and nonhuman primates

Synapse

Volumn 25, Issue 3, 1997, Pages 306-308

  Heinz, Andreas ^a   Jones, Douglas W ^a   Gorey, Julia G ^a   Knable, Michael B ^a   Lee, Kan Sam ^a   Saunders, Richard C ^a   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

2 carbomethoxy 3 (4 iodophenyl)tropane; 5 HT transporter; dopamine transporter; HPLC; metabolism; single photon emission computed tomography; SPET

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ACETIC ACID ETHYL ESTER; ACETONITRILE; DOPAMINE TRANSPORTER; DRUG METABOLITE; IODINE 123; ORGANIC SOLVENT; RADIOPHARMACEUTICAL AGENT; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DOPAMINERGIC SYSTEM; DRUG BLOOD LEVEL; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RHESUS MONKEY; SEROTONINERGIC SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPECIES DIFFERENCE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; HUMANS; IODINE RADIOISOTOPES; MACACA MULATTA; RADIOLIGAND ASSAY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0030900946     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199703)25:3<306::AID-SYN10>3.0.CO;2-U     Document Type: Article

References (4)

1. 123I]β-CIT) in non-human primates: Pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI. Nucl. Med. Biol., 20:597-606.
2. 123I]β-CIT in human plasma may obstruct quantitation of the dopamine transporter. Synapse, 19:297-300.
3. Coats, A.C. (1980) Quantitative Structure-Activity Relationships. In: Radiopharmaceuticals Structure-Activity Relationships. R.P. Spencer, ed. Grune & Stratton, New York, pp. 3-22.
4. 123I]β-CIT: Pharmacological characterization of brain uptake in nonhuman primates. Synapse, 13:295-309.