Glutamine or glutamate release by the liver constitutes a major mechanism for nitrogen salvage

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 2 35-2, 1997, Pages

  Remesy C ^a   Moundras, C ^a   Morand, C ^a   Demigne C ^a  

^a CEMAGREF   (France)

Author keywords

amino acids; casein; diet; intestine; protein

Indexed keywords

AMINO ACID; CASEIN; GLUTAMIC ACID; GLUTAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; INTESTINE; LIVER CELL; MALE; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN RESTRICTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT; UREA CYCLE;

EID: 0030900340     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.2.g257     Document Type: Article

References (34)

1. Abumrad, N. N., N. Yazigi, E. Cerosimo, H. Hourani, S. Gedde, N. Bulus, and P. Williams. Glutamine metabolism during starvation. J. Parent. Enteral Nutr. 14, Suppl. 4: 71S-76S, 1990.
2. Aikawa, T., H. Matsutaka, H. Yamamoto, T. Okuda, E. Ishikawa, T. Kawano, and H. Matsumura. Gluconeogenesis and amino acids. II. Inter-organal relations and roles of glutamine and alanine in the amino acid metabolism of fasted rats. J. Biochem. 74: 1003-1017, 1973.
3. Atkinson, D. E., and E. Bourke. Metabolic aspects of the regulation of systemic pH. Am. J. Physiol. 252 (Renal Fluid Electrolyte Physiol. 21): F947-F956, 1987.
4. Boyde, T. R. C., and M. Rahmatullah. Optimization of conditions for the colorimetric determination of citrulline, using diacetylmonoxime. Anal. Biochem. 107: 424-431, 1980.
5. Brosnan, J. T., K.-C. Man, D. E. Hall, S. A. Colbourne, and M. E. Brosnan. Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am. J. Physiol. 244 (Endocrinol Metab. 7): E151-E158, 1983.
6. Buttrose, M., D. McKellar, and T. C. Welbourne. Gut-liver interaction in glutamine homeostasis: portal ammonia role in uptake and metabolism. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E746-E750, 1987.
7. Casado, J., M. Pastor-Anglada, and X. Remesar. Hepatic uptake of amino acids at mid-lactation in the rat. Biochem. J. 245: 297-300, 1987.
8. 13N]ammonia in rat liver in vivo. J. Biol. Chem. 262: 1073-1080, 1987.
9. 13N-labeled glutamate, alanine and glutamine(amide) in rat liver. J. Biol. Chem. 263: 12268-12273, 1988.
10. Demigné, C., P. Fafournoux, and C. Rémésy. Respective contribution of plasma branched-chain amino acids and 2-keto acids to the hepatic metabolism of the carbon moiety of branched-chain amino acids in fed rats. J. Nutr. 116: 2201-2208, 1986.
11. Desbordes, J., and P. Samorcq. Techniques d'exploration fonctionnelle des reins. Clairance de l'acide para-aminohippurique. In: Techniques de Laboratoire. Paris: Masson, 1963, p. 363-366.
12. Fafournoux, P., C. Demigné, and C. Rémésy. Fluxes and membrane transport of amino acids in rat liver under different protein diets. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E614-E625, 1990.
13. Gebhardt, R. Metabolic zonation of the liver: regulation and implication for liver function. Pharmacol. Ther. 53: 275-354, 1992.
14. Gebhardt, R., K. Lindros, W. Lamers, and A. F. M. Moorman. Hepatocellular heterogeneity in ammonia metabolism: demonstration of limited colocalization of carbamoyl-phosphate synthetase and glutamine synthetase. Eur. J. Cell Biol. 56: 464-467, 1991.
15. Häussinger, D. Nitrogen metabolism in liver: structural and functional organization and physiological relevance. Biochem. J. 267: 281-290, 1990.
16. Häussinger, D., and W. Gerok. Hepatocyte heterogeneity in glutamate uptake by isolated perfused rat liver. Eur. J. Biochem. 136: 421-425, 1983.
17. Lutsy, C. J. Carbamoyl phosphate synthetase I of rat liver mitochondria. Purification, properties and polypeptide molecular weight. Eur. J. Biochem. 85: 373-383, 1978.
18. Meijer, A. J., W. H. Lamers, and R. A. Chamuleau. Nitrogen metabolism and ornithine cycle function. Physiol. Rev. 70: 701-748, 1990.
19. Pardridge, W. M. Unidirectional influx of glutamine and other neutral amino acids into liver of fed and fasted rats in vivo. Am. J. Physiol. 232 (Endocrinol. Metab. Gastrointest. Liver Physiol. 1): E492-E496, 1977.
20. 15N] ammonia into plasma amino acids and urea. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E508-E515, 1995.
21. Pinkus, L. M., and H. G. Windmueller. Phosphate-dependent glutaminase of small intestine and localization and role in intestinal glutamine metabolism. Arch. Biochem. Biophys. 182: 506-517, 1990.
22. Rémésy, C., and C. Demigné. Specific effects of fermentable carbohydrates on blood urea flux and ammonia absorption in the rat cecum. J. Nutr. 119: 560-565, 1989.
23. Rémésy, C., C. Demigné, and F. Aufrère. Interorgan relationship between glucose, lactate, and amino acids in rats fed on high-carbohydrate or high-protein diets. Biochem. J. 170: 321-329, 1978.
24. Rémésy, C., C. Morand, C. Demigné, and P. Fafournoux. Control of hepatic utilization of glutamine by transport processes or cellular metabolism in rats fed a high protein diet. J. Nutr. 118: 569-578, 1988.
25. Rowe, W. B., R. A. Ronzio, V. P. Wellner, and A. Meister. Glutamine synthetase. Methods Enzymol. 17A: 900-910, 1970.
26. Schröck, H., and L. Goldstein. Interorgan relationships for glutamine metabolism in normal and acidotic rats. Am. J. Physiol. 240 (Endocrinol. Metab. 3): E519-E525, 1981.
27. Souba, W. W. Glutamine: a key substrate for the splanchnic bed. Annu. Rev. Nutr. 11: 285-308, 1991.
28. Stoll, B., and D. Häussinger. Hepatocyte heterogeneity in uptake and metabolism of malate and related dicarboxylates in perfused rat liver. Eur. J. Biochem. 195: 121-129, 1991.
29. Tatibana, M., and K. Shigesada. Regulation of urea biosynthesis by the acetylglutamate-arginine system. In: The Urea Cycle, edited by S. Grisolia, R. Baguena, and F. Mayor. London: Wiley, 1976, p. 301-313.
30. Taylor, P. M., and M. J. Rennie. Perivenous localization of Na-dependent glutamate transport in perfused rat liver. FEBS Lett. 221: 370-374, 1987.
31. Watford, M. Glutamine metabolism in rat small intestine: synthesis of three-carbon products in isolated enterocytes. Biochim. Biophys. Acta 1200: 73-78, 1994.
32. Watford, M., N. Vincent, Z. Zhan, J. Fannelli, T. Kowalski, and Z. Kovacevic. Transcriptional control of rat hepatic glutaminase expression by dietary protein level and starvation. J. Nutr. 124: 493-499, 1994.
33. Windmueller, H. G. Glutamine utilization by the small intestine. Adv. Enzymol. 53: 202-238, 1982.
34. Yamamoto, M., T. Aikawa, H. Matsutaka, T. Okuda, and F. Ishikawa. Interorganal relationships of amino acid metabolism in fed rats. Am. J. Physiol. 221: 1428-1433, 1974.