Enantioselective Horner-Wadsworth-Emmons reaction using chiral lithium 2-aminoalkoxides

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 4, 1997, Pages 753-755

  Kumamoto, Takuya ^a   Koga, Kenji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

chiral axis; chiral base; chiral lithium 2 aminoalkoxide; enantioselective asymmetric synthesis; Horner Wadsworth Emmons reaction

Indexed keywords

ALKENE; AMINOALCOHOL; CYCLOHEXANONE DERIVATIVE; LITHIUM DERIVATIVE; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHIRALITY; COLUMN CHROMATOGRAPHY; DIASTEREOISOMER; ENANTIOMER; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; RACEMIC MIXTURE; STEREOCHEMISTRY; SYNTHESIS;

EID: 0030900101     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.753     Document Type: Article

References (28)

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25. Chiral column for GC analysis: CHROMPAK CP-Cyclodextrin-β-236-μ, 50 m.
26. Chiral column for HPLC analysis: DAICEL CHIRALCEL OD-H; solvent: hexane-2-propanol (1000:1).
27. 3) of the methine protons adjacent to the phosphonate group are observed at 3.03 ppm (d, J=23.0 Hz) for dl-5, at 3.44 ppm (d, J=24.1 Hz) for the other diastereomer of dl-5, and at 3.09 ppm (d, J=22.4 Hz) for dl-6. matrix presented
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