High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine(2A) receptors: Evidence in favor of a modified ternary complex model

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 576-583

  Roth, Bryan L ^a   Choudhary, M S ^a   Khan, N ^a   Uluer, A Z ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 IODO 3,5 DIMETHOXYPHENYLISOPROPYLAMINE; BUFOTENINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITIDE; QUIPAZINE; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SECOND MESSENGER; SIGNAL TRANSDUCTION;

2,5-DIMETHOXY-4-METHYLAMPHETAMINE; 3T3 CELLS; ANIMALS; BINDING SITES; BUFOTENIN; KINETICS; METHOXYDIMETHYLTRYPTAMINES; MICE; MODELS, CHEMICAL; PHENYLALANINE; PHOSPHATIDYLINOSITOLS; POINT MUTATION; QUIPAZINE; RADIOLIGAND ASSAY; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; SEROTONIN AGONISTS; TRANSFECTION;

EID: 0030899598     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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