Three-dimensional visualization and quantification of the benzodiazepine receptor population within a living human brain using PET and MRI

European Archives of Psychiatry and Clinical Neuroscience

Volumn 247, Issue 2, 1997, Pages 61-70

  Pauli, Stefan ^a   Sedvall, Göran ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

3D quantification; 3D visualization; Benzodiazepine receptors; Human brain; MRI; Positron emission tomography; Volume rendering; 11C Flumazenil

Indexed keywords

BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; FLUMAZENIL; RADIOLIGAND;

ADULT; ARTICLE; BRAIN REGION; BRAIN SIZE; COMPUTER GRAPHICS; COMPUTER PROGRAM; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING;

EID: 0030899352     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02900195     Document Type: Article

References (41)

1. Andreasen NC, Oleary DS, Arndt S, Cizadlo T, Hurtig R, Rezai K, Watkins GL, Ponto LLB, Hichwa RD (1995a) Short-term and long-term verbal memory: a positron emission tomography study. Proc Natl Acad Sci USA 92:5111-5115
2. Andreasen NC, Swayze V, Oleary DS, Nopoulos P, Cizadlo T, Harris G, Arndt S, Flaum M (1995b) Abnormalities in midline attentional circuitry in schizophrenia: evidence from magnetic resonance and positron emission tomography. Eur Neuropsychopharmacol 5:37-41
3. Argiro VJ (1990) Seeing in volume. Pixel 1:35-39
4. Bergström M, Boetius J, Eriksson L, Greitz T, Ribbe T, Widén L (1981) Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr 5:136-141
5. Blomqvist G, Pauli S, Farde L, Eriksson L, Persson A, Halldin C (1990) Maps of receptor binding parameters in the human brain: a kinetic analysis of PET measurements. Eur J Nucl Med 16:257-265
6. Catmull EA (1974) Subdivision algorithm for computer display of curved surfaces. PhD thesis report UTEC-CSc-74-133, Computer Science Department, University of Utah, Salt Lake City, Utah
7. Drebin RA, Carpenter L, Hanrahan P (1988) Volume rendering. Comput Graph 22:65-74
8. Farde L, Hall H, Ehrin E, Sedvall G (1986) Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science 231:258-261
9. Fiez JA, Raichle ME, Balota DA, Tallal P, Petersen SE (1996) PET activation of posterior temporal regions during auditory word presentation and verb generation. Cereb Cortex 6:1-10
10. Foley JD, Dam A van, Feiner SK, Hughes JF (1990) The Phong lighting model. In: Computer graphics: principles and practice, 2nd edn. Addison-Wesley, London, pp 729-731
11. Friston KJ, Frith CD, Liddle PF, Frackoviack RSJ (1991) Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 11:690-699
12. Frost J, Meltzer C, Zubieta J, Links J, Brakeman P, Stumpf M, Kruger M (1996) MR-based correction of paxrtial volume effects in brain PET imaging. In: Myers R, Cunningham V, Bailey D, Jones T (eds) Quantification of brain function using PET. Academic Press, New York, pp 152-157
13. Hall H, Litton J-E, Halldin C, Kopp J, Sedvall G (1992) Studies on the binding of [3H]flumazenil and [3H]sarmazenil in post mortem human brain. Hum Psychopharmacol 7:367-377
14. Hall H, Sedvall G, Magnusson O, Kopp J, Halldin C, Farde L (1994) Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain. Neuropsychopharmacology 11 (4):245-256
15. Halldin C, Stone-Elander S, Thorell J-O, Persson A, Sedvall G (1988) 11C-labeling of Ro 15-1788 in two different positions, and also 11C-labeling of its main metabolite Ro 15-3890, for PET studies of benzodiazepine receptors. Appl Radiat Isot 39: 993-997
16. Harris LD, Robb RA, Yuen TS, Ritman EL (1978) Non-invasive numerical dissection and display of anatomic structure using computerized X-ray tomography. Proc SPIE 152:10-18
17. Herman GT, Liu HK (1979) Three-dimensional display of organs from computed tomograms. Comput Graph Image Process 9(1): 1-21
18. Kuhar MJ, Lloyd DG, Appel N, Loats HL (1991) Imaging receptors by computer-assisted approaches. J Chem Neuroanat 4: 319-327
19. Lammertsma A, Lassen N, Prevett M et al. (1993) Quantification of benzodiazepin receptors in vivo using 11C-flumazenil: application of the steady-state principle. In: Uemura K, Lassen NA, Jones T, Kanno I (eds) Quantification of brain function. Excerpta Medica, Amsterdam, pp 303-311
20. Lassen NA (1992) Neuroreceptor quantitation in vivo by the steady-state principle using constant infusion or bolus injection of radioactive tracers. J Cereb Blood Flow Metab 12:709-716
21. Lassen NA, Bartenstein PA, Lammertsma AA, Prevett MC, Turton DR, Luthra SK, Osman S, Bloomfield PM, Jones T, Patsalos PN et al. (1995) Benzodiazepine receptor quantification in vivo in humans using [11C]flumazenil and PET: application of the steady-state principle. J Cereb Blood Flow Metab 15(1):152-165
22. Latchaw R E, Ugurbil K, Hu X (1995) Functional MR imaging of perceptual and cognitive functions. Neuroimaging Clin North Am 5:193-205
23. Levoy M (1988) Display of surfaces from volume data. IEEE Comput Graph Applications 8:29-37
24. Lorenson WE, Harvey CC (1987) Marching cubes: a high-resolution 3-D surface construction algorithm. Comput Graph ACM SIGGRAPH '87 Conference Proceedings
25. Mazière M, Hantraye P, Prenant C, Sastre J, Comar D (1984) Synthesis of ethyl 8-fluoro-5,6-dihydro-5-[11C)methyl-6-oxo-4H-imidazo[1,5-a][1, 4]benzodiazepine-3-carboxylate (RO15.1788-11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography. Int J Appl Radiat Isot 35:973-978
26. Persson A, Ehrin E, Farde L, Litton J-E, Mindus P, Sedvall G (1985) Imaging of 11-C-labeled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography. J Psychiatr Res 19:609-622
27. Persson A, Pauli S, Halldin C, Stone-Elander S, Farde L, Sjögren I, Sedvall G (1989) Saturation analysis of specific 11C Ro 15-1788 binding in the human neocortex using positron emission tomography. Hum Psychopharmacol 4:21-31
28. Price JC, Mayberg HS, Dannals RF, Wilson AA, Ravert HT, Sadzot B, Rattner Z, Kimball A, Feldman MA, Frost JJ (1993) Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modeling, positron emission tomography, and [11C]flumazenil. J Cereb Blood Flow Metab 13(4):656-667
29. Raichle ME (1994) Images of the mind: studies with modern imaging techniques. Annu Rev Psychol 45:333-356
30. Roland PE, Zilles K (1994) Brain atlases: a new research tool. Trends Neurosci 17:458-467
31. Russ JC (1995) The image processing handbook, 2nd edn. CRC Press, Boca Raton, Florida
32. Sedvall G, Farde L, Persson A, Wiesel F-A (1986) Imaging of neurotransmitter receptors in the living human brain. Arch Gen Psychiatry 43:995-1005
33. Sedvall G, Karlsson P, Lundin A, Anvret M, Suhara T, Halldin C, Farde L (1994) Dopamine D1 receptor number: a sensitive PET marker for early brain degeneration in Huntington's disease. Eur Arch Psychiatry Clin Neurosci 243:249-255
34. Sedvall G, Farde L (1995) Dopamine receptors in schizophrenia. Lancet 346:743-749
35. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916
36. Toga AW (1990) Three-dimensional neuroimaging. Raven Press, New York
37. Van Zandt WL, Argiro VJ (1989) A new inlook on life. UNIX Rev 7:52-57
38. Wagner HNJ, Burns HD, Dannals RF, Wong DF, Långström B, Duelfer T, Frost JJ, Ravert HT, Links JM, Rosenbloom SB, Lukas SE, Kramer AV, Kuhar MJ (1983) Imaging dopamine receptors in the human brain by positron tomography. Science 221:1264-1266
39. Watt A (1991) Volume rendering. In: 3D Computer graphics. Addison-Wesley, London, pp 313-319
40. Weinhard K, Dahlbom M, Eriksson L, Michel C, Bruckbauer T (1994) The ECAT EXACT HR: performance of a new high-resolution positron scanner. J Comput Assist Tomogr 18:110-118
41. Wilhems J, Van Gelder A (1991) A coherent projection approach for direct volume rendering. Comput Graph 25:275-284