Tissue and species variation in the vascular receptor binding of 3H- P1075, a potent K(ATP) opener vasodilator

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 1, 1997, Pages 255-260

  Higdon, Nicole R ^a   Khan, Sajida A ^a   Buchanan, Lewis V ^a   Meisheri, Kaushik D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; CORONARY ARTERY; DRUG RECEPTOR BINDING; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; VASODILATATION;

ANIMALS; AORTA; CORONARY VESSELS; DOGS; GUANIDINES; MALE; MESENTERIC ARTERIES; ORGAN SPECIFICITY; POTASSIUM CHANNELS; PYRIDINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; VASODILATOR AGENTS;

EID: 0030898959     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. + channel openers in rat aorta. J. Biol. Chem. 267: 11689-11692, 1992.
2. COLDWELL, M. C. AND HOWLETT, D. R.: Specificity of action of the novel antihypertensive agent, BRL-34915, as a potassium charmel activator: Comparison with nicorandil. Biochem. Pharmacol. 36: 3663-3669, 1987.
3. COOK, N. S. AND QUAST, U.: Potassium channel pharmacology. In: Potassium Channels: Structure, Classification, Function, and Therapeutic Potential, ed. by N. S. Cook, pp. 181-258, John Wiley and Sons, New York, 1990.
4. 3H]P1075. FASEB J. 7: A354, 1993.
5. 3H]P1075 to brain, heart, and skeletal muscle membranes. FASEB J. 10: A138, 1996.
6. EDWARDS, G. AND WESTON, A. H.: The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol. 33: 597-637, 1993.
7. + channels in mouse pancreatic β cells. Br. J. Pharmacol. 98: 957-965, 1989.
8. HOFFMAN, F. J., LENFERS, J. B., NIEMERS, E., PLEISS, U., SCRIABINE, A. AND JANIS R. A.: High affinity binding of a potassium channel agonist to intact rat insulinoma cells. Biochem. Biophys. Res. Commun. 190: 551-558, 1993.
9. MANELY, P. W., QUAST, U., ANDRES, H. AND BRAY, K.: Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: Receptor interactions of structurally different classes of potassium channel openers and blockers. J. Med. Chem. 36: 2004-2010, 1993.
10. MANNHOLD, R., LEMOINE, H. AND JASPERT S.: Comparison of binding and relaxant properties of potassium channel openers in calf coronary arteries. N. S. Arch Pharmacol. 353: R54, 1996.
11. + channel opener. J. Pharmacol. Exp. Ther. 258: 1091-1097 1991a.
12. + channel-dependent as well as -independent components of pinacidil-mduced vasodilation. J. Pharmacol Exp. Ther. 256: 492-499, 1991b.
13. MEISHERI, K. D., JOHNSON G. A. AND PUDDINGTON, L. COMMENTARY: Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem. Pharmacol. 45: 271-279, 1993a.
14. + channel openers. J. Vasc. Res. 30: 2-12, 1993b.
15. + channel openers, diazoxide and cromakalim and their inhibition by glibenclamide. J. Pharmacol. Exp. Ther. 250: 261-271, 1989.
16. 3H]P1075 in rat isolated aorta: Relationship to functional effects of openers and blockers. Mol. Pharmacol. 43: 474-481, 1993.
17. ATP opener, lemakalim on systemic, coronary, and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerine, and acetylcholine. J. Pharmacol. Exp. Ther. 265: 1026-1037, 1993.
18. TRIGGLE, D. J.: Potassium channels and potassium channel modulation. Neurotransmission 6: 1-5, 1990.
19. + current in canine coronary smooth muscle cells. Pflugers Arch. 427: 110-120, 1994.