Interleukin 6 gene-transfected mouse mammary adenocarcinoma: Tumour cell growth and metastatic potential

Journal of Pathology

Volumn 182, Issue 1, 1997, Pages 76-85

  Di Carlo, Emma ^a   Modesti, Andrea ^a   Castrilli, Graziella ^a   Landuzzi, Lorena ^b,c   Allione, Alessandra ^d   De Giovanni, Carla ^b   Musso, Tiziana ^d   Musiani, Piero ^a,e  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c IST Sezione Biotecnologie di Bologna   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e Ospedale 'SS Annunziata'   (Italy)

Author keywords

amphiregulin; cytokine gene transfection; interleukin 6; metastasis; murine mammary adenocarcinoma

Indexed keywords

INTERLEUKIN 6;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; CELL GROWTH; CELL ULTRASTRUCTURE; FEMALE; GROWTH RATE; MACROPHAGE ACTIVATION; METASTASIS POTENTIAL; MICROSCOPIC ANATOMY; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOCARCINOMA; ANIMALS; CELL DIVISION; FEMALE; INTERLEUKIN-6; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030898156     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199705)182:1<76::AID-PATH805>3.0.CO;2-B     Document Type: Article

References (33)

1. Forni G, Foa R, Santoni A, Frati L. Cytokine-Induced Tumor Immunogenicity. From Exogenous Molecules to Gene Therapy. London: Academic Press, 1994: 97-345.
2. Blankenstein T, Qin Z, Uberla K, et al. Tumor suppression after tumor cell-targeted tumor necrosis factor-alpha gene transfer. J Exp Med 1991; 173: 1047-1052.
3. Okada M. The in vivo anti-tumor effect of IL-6 by transfection with human 1L-6 cDNA. Proc Jpn Cancer Assoc 1990; 49: 40-40 (Abstract).
4. Revel M. Growth regulatory functions of IL6 and antitumor effects. Res Immunol 1992; 143: 769-773.
5. Ohe Y, Podack Er, Olsen KJ, el al. Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shorten survival in syngenic mice. Br J Cancer 1993: 67: 939-944.
6. Nanni P, De Giovanni C, Lollini PL, Nicoletti G, Prodi G. A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma. Clin Exp Metastasis 1983; 1: 373-380.
7. Musiani P, Allione A, Modica A, et al. Role of neutrophils and lymphocytes in inhibition of a mouse mammary adenocarcinoma engineered to release IL2, IL4., IL7, ILl0, IFN-alpha, IFN-gamma, and TNF-alpha. Lab Invest 1996; 74: 46-157.
8. Breen EC, Rezai AR, Nakajima K, el al. Infection with HIV is associated with elevated IL6 levels and production. J lmmunol 1990; 144: 480-484.
9. Gallo P, Frei K, Bordorf C, Lazdins J, Tavolato B, Fontana A. Human immunodeficiency virus type I (HIV-I) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J Neuroimmunol 1989; 23: 109,
10. Nakajima K, Martinez-Masa O, Hirano T, et al. Induction of IL6 (B stimulatory factor 2/IFN-beta2) production by HIV. J lmmunol 1988; 142: 531-536.
11. Cook PW, Mattox PA, Keeble WW, et al. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol 1991; 11: 2457-2557.
12. Woodworth CD, McMullin E, Iglesias M, Plowman GD. Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells. Proc Natl Acad Sci USA 1995; 92: 2840-2844.
13. Iglesias M, Plowman GD, Woodworth CD. Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro. Am J Pathol 1995; 146: 944-952.
14. De Giovanni C, Melani C, Nanni P, et al. Redundancy of autocrine loops in human rhabdomyosarcoma cells. Induction of differentiation by suramin. Br J Cancer 1995; 72: 1224-1229.
15. Scott J, Urdea M, Quiroga M, et al. Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. Science 1983; 221: 236-240.
16. Das SK, Chakraborty I, Paria BC, Wang XN, Plowman GD, Dey SK. Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol Endocrinol 1995; 9: 691-705.
17. De Giovanni C, Palmieri G, Nicoletti G, el al. Immunological and nonimmunologic influence of H-2Kb gene transfection on the metastatic ability of B16 melanoma cells. Int J Cancer 1991; 48: 270-276.
18. Vecchi A, Garlanda C, Lampugnani MG, et al Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol 1994; 63: 247-254.
19. Salomon DS, Normanno N, Ciardiello F, Brandt R, Shoyab M, Todaro GJ. The role of amphiregulin in breast cancer. Breast Cancer Res Tr 1995; 33: 103-114.
20. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today 1990; 11: 443-149.
21. Tamm I, Cardinale I, Krueger J, Murphy JS, May LT, Sehgal PB. Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells. J Exp Med 1989; 170: 1649-1669.
22. Basolo F, Calvo S, Fiore L, Conaldi PG, Falcone V, Toniolo. Growth-stimulating activity of interleukin 6 on human mammary epithelial cells transfected with the int-2 gene. Cancer Res 1993; 53: 2957-2960.
23. Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ. Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science 1989; 243: 1074-1076.
24. Plowman GD, Green JM, McDonald VL, et al. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity, Mol Cell Biol 1990; 10: 1969-1981.
25. Salomon DS, Kim N, Saeki T, Ciardello F. Transforming growth factor-alpha: an oncodevelopmental growth factor. Cancer Cells 1990; 2: 389-397.
26. Todaro GJ, Rose TM, Spooner CE, Shoyab M, Plowman GD. Cellular and viral ligands that interact with the EGF receptor. Semin Cancer Biol 1990; 1: 257-263.
27. Kimura H, Fisher WH, Shubert D. Structure, expression and function of a Schwannoma-derived growth factor. Nature 1990; 348: 257-260.
28. van Netten GP, Ashmead BJ, Cavers D, et al. 'Macrophages' and their putative significance in human breast cancer. Br J Cancer 1992; 66: 220-221.
29. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv lmmunol 1993; 54: 1-78.
30. May LT, Torcia G, Cozzolino F, et al. Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation. Biochem Biophys Res Commun 1989; 159: 991-998.
31. Motro B, Itin A, Sachs L, Keshet E. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 1990; 87: 3092-3096.
32. Holzinger C, Weissinger E, Zuckermann A, et al. Effects of interleukin-1, -2, -4, -6, interferon-gamma and granulocyte/macrophage colony stimulating factor on human vascular endothelial cells. Immunol Lett: 1993; 35: 109-118.
33. Sunderkotter C, Goebeler M, Sculze-Osthoff K, Bhardwaj R, Sorg C. Macrophage-derived angiogenesis factors. Pharmacol Ther 1991; 51: 195-216.