Corneal concentrations and preliminary toxicological evaluation of an itraconazole/dimethyl sulphoxide ophthalmic ointment

Journal of Veterinary Pharmacology and Therapeutics

Volumn 20, Issue 2, 1997, Pages 100-104

  Ball, M A ^a   Rebhun, W C ^a   Trepanier, L ^a   Gaarder, J ^a   Schwark, W S ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; ITRACONAZOLE;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HORSE; NONHUMAN; OINTMENT; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 0030897497     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1997.00822.x     Document Type: Article

References (28)

1. Badcock, N. & Davies, A. (1990) Assay of itraconazole in nail clipping by reverse phase, high performance liquid chromatography. Annals Clinical Biochemistry, 27, 506-508.
2. Ball, M.A., Rebhun, W.C., Trepanier, L. & Schwark, W.S. (1996) Evaluation of a 1% itraconazole-30% DMSO topical ophthalmic ointment: corneal concentrations and toxicologic evaluation (Part 1), and prospective clinical trial (Part 2). In Proceedings 42nd American Association of Equine Practitioners, 289-291.
3. Barton, M.H. (1992) Equine keratomycosis. Compendium Continuing Education, 14, 936-944.
4. Basch, H. & Gadebusch, H. (1968) In vitro antimicrobial activity of dimethylsulfoxide. Applied Microbiology, 16, 1953-1954.
5. Bistner, S.I. & Riis, R.C. (1979) Clinical aspects of mycotic keratitis in the horse. Cornell Veterinarian, 69, 364-372.
6. Dupont, B. & Drouhet, E. (1987) Early experience with itraconazole in vitro and in patients: Pharmacokinetic studies and clinical results. Reviews of Infectious Diseases, 9, S71-S76.
7. Foster, C.S. & Stefanyszyn, M. (1979) Intraocular penetration of miconazole in rabbits. Archives of Ophthalmology, 97, 1703-1706.
8. Ganer, A., Arathoon, E. & Stevens, D. (1987) Initial experience in therapy for progressive mycosis with itraconazole, the first clinically studied triazole. Reviews of Infectious Disease, 9, S77-S86.
9. Gordon, D.M. (1967) Dimethyl sulfoxide in ophthalmology, with especial reference to possible toxic effects. Annals of the New York Academy of Sciences, 141, 392-401.
10. Hahn, Y.H., Ahearn, D.G. & Wilson, L.A. (1993) Comparative efficancy of amphotericin B, clotrimazole and itraconazole against Aspergillus spp.: an in vitro study. Mycopathologia, 123, 135-140.
11. Jacob, S.W. & Wood, D.C. (1971) Dimethyl sulfoxide (DMSO) - a status report. Clinical Medicine, 78, 21-31.
12. Johns, K.J. & O'Day, D.M. (1988) Pharmacologic management of keratomycosis. Survey of Ophthalmology, 33, 178-187.
13. Kern, T., Brooks, D. & White, M. (1983) Equine keratomycosis: Current concepts of diagnosis and therapy. Equine Veterinary Journal: Ophthalmology supplement: 33-38.
14. Leber, T. (1879) Keratomycosis aspergillina als Ursache von Hypopyon-keratitis . Albrecht von Graefes Archiv für Ophthalmologie, 25, 285-301.
15. Mohan, M., Gupta, S., Vajpayee, R., Kalra, V. & Sachdev, M. (1988) Management of keratomycosis with 1% silver sulfadiazine: A prospective controlled clinical trial in 110 cases. In The Cornea: Transactions of the World Congress on the Cornea III. Ed. Cavanagh. H.D., pp. 495-499. Raven Press, New York.
16. Moore, C.P., Fales, W.H., Whttington, P. & Bauer, L. (1983) Bacterial and fungal isolates from equidae with ulcerative keratitis. Journal of the American Veterinary Medical Association, 186, 600-603.
17. Nicolas, E. (1914) General remarks on the anatomy of the eye. In Veterinary and Comparative Ophthalmology. Ed. Gray, H., pp. 1-7, Brown, London.
18. Peiffer, R.L. (1979) Keralomycosis in the horse. Equine Practice, 1, 32-38.
19. Remmel, R.P., Dombrovskis, D. & Canafax, D.M. (1988) Assay of itraconazole in leukemic patient plasma by reverse-phased small-bore liquid chromalography. Journal of Chromatography, 432, 388-394.
20. Rubin, L.F. & Barnett, K.C. (1967) Ocular effects of oral and dermal application of dimethyl sulfoxide in animals. Annals of the New York Academy of Sciences, 141, 333-345.
21. Rubin, L.F. & Mattis, P.A. (1966) DMSO: Lens changes in dogs during oral administration. Science, 153, 83-84.
22. Samuelson, D.A., Andressen, B.S. & Gwin, R.M. (1984) Conjunctival fungal flora in horses, cattle, dogs, and cats. Journal American Veterinary Medical Association, 184, 1240-1243.
23. Schmitt, H.J., Edwards, F. Andrade, J., Niki, Y. & Armstrong, D. (1992) Comparison of azoles against aspergilli in vitro and in an experimental model of pulmonary aspergillosis. Chemotherapy, 38, 118-26.
24. Schuh, J., Ross, C. & Meschter, C. (1988) Concurrent mercuric blister and DMSO application as a cause of mercury toxicity in two horses. Equine Veterinary Journal, 20, 69-71.
25. Thomas, P.A., Abraham, D.J., Kalavathy, C.M. & Rajasekaran, J. (1988) Oral itraconazole therapy for mycotic keritis. Mycoses, 31, 271-279.
26. Torres, M.A., Mohamed, J., Cavazos-Adame, H. & Martinez, L.A. (1985) Topical ketoconazole for fungal keratilis. Americian Journal of Ophthomology, 100, 293-298.
27. Van Cutsem, J., Van Gerven, F. & Janssen, P.A. (1987) Activity of orally, topically, and parenterally administered itraconaxole in the treatment of superficial and deep mycoses: animal models. Review of Infectious Disease, 9, s15-s32.
28. Wood, D.C., Sweet, D. & Van Dolah, J. (1967) A study of DMSO and steroids in rabbit eyes. Annals of the New York Academy of Sciences, 141, 346-380.