Thrombopoietin: The primary regulator of platelet production

Trends in Endocrinology and Metabolism

Volumn 8, Issue 2, 1997, Pages 45-50

  Kaushansky, Kenneth ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; RECOMBINANT PROTEIN; THROMBOPOIETIN;

HORMONAL REGULATION; HUMAN; MEGAKARYOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; THROMBOCYTOPOIESIS;

EID: 0030897002     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(96)00269-X     Document Type: Review

References (58)

1. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c- mpl. Blood. 87:1996;2162-2170.
2. Avraham H, Vannier E, Cowley Set al. Effects of the stem cell factor, c- kit ligand, on human megakaryocytic cells. Blood. 79:1992;365-371.
3. Banu N, Wang JF, Deng B, Groopman JE, Avraham H Modulation of megakaryocytopoiesis by thrombopoietin: the c- mpl ligand. Blood. 86:1995;1331-1338.
4. Bartley TD, Bogenberger J, Hunt Pet al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell. 77:1994;1117-1124.
5. Basser RL, Rasko JEJ, Clarke Ket al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet. 348:1996;1279-1281.
6. Broudy VC, Lin NL, Kaushansky K Thrombopoietin (c- mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood. 85:1995;1719-1726.
7. Burstein SA, Mei R-L, Henthorn J, Friese P, Turner K Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro. J Cell Physiol. 153:1992;305-312.
8. Carver-Moore K, Broxmeyer HE, Luoh SMet al. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood. 88:1996;803-808.
9. Debili N, Wendling F, Katz Aet al. The Mpl ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood. 86:1995;2516-2525.
10. De Sauvage FJ, Luoh S-M, Carver-Moore Ket al. Deficiencies in early and late stages of megakaryocytopoiesis in TPO-KO mice [abst]. Blood. 86:1995;255a.
11. Fanucchi M, Glaspy J, Crawford Jet al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. New Engl J Med. 336:1997;404-409.
12. Farese AM, Hunt P, Grab LB, MacVittie TJ Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony stimulating factor enhances multi-lineage hematopoietic reconstitution in nonhuman primates following radiation-induced marrow aplasia. J Clin Invest. 97:1996;2145-2151.
13. Gastl G, Plante M, Finstad CLet al. High IL-6 levels in ascitic fluid correlate with reactive thrombocytosis in patients with epithelial ovarian cancer. Br J Haematol. 83:1993;433-441.
14. Hill R, Levin J Partial purification of thrombopoietin using lectin chromatography. Exp Hematol. 14:1986;752-759.
15. Hill RJ, Levin J Regulators of thrombopoiesis: their biochemistry and physiology. Blood Cells. 15:1989;141-166.
16. Hill RJ, Warren MK, Levin J, Gouldie J Evidence that interleukin-6 does not play a role in the stimulation of platelet production after induction of acute thrombocytopenia. Blood. 80:1992;346-351.
17. Ishibashi T, Shikama Y, Kimura Het al. Thrombopoietic effects of interleukin-6 in long-term administration in mice. Exp Hematol. 21:1993;640-646.
18. Kaushansky K Thrombopoietin: The primary regulator of platelet production. Blood. 86:1995;419-432.
19. Kaushansky K, O'Hara RJ, Berkner Ket al. Genomic cloning, characterization and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA. 83:1986;3101-3105.
20. Kaushansky K, Lok S, Holly RDet al. Promotion of megakaryocyte progenitor expansion and differentiation by the c- mpl ligand thrombopoietin. Nature. 369:1994;568-571.
21. Kaushansky K, Broudy VC, Lin Net al. Thrombopoietin, the Mpl-ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA. 92:1995;3234-3238.
22. Kaushansky K, Broudy VC, Grossmann Aet al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest. 96:1995;1683-1687.
23. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC Thrombopoietin expands erythroid, granulocyte-macrophage and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hamatol. 23:1996;265-269.
24. Kimura H, Ishibashi T, Uchida T, Maruyama Y, Friese P, Burstein SA Interleukin 6 is a differentiation factor for human megakaryocytes in vitro. Eur J Immunol. 20:1990;1927-1931.
25. Kishimoto T, Taga T, Akira S Cytokine signal transduction. Cell. 76:1994;253-262.
26. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood. 86:1995;2494-2499.
27. Ku H, Yonemura Y, Kaushansky K, Ogawa M Thrombopoietin, the ligand for the Mpl receptor, synergy with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood. 87:1996;4544-4551.
28. Kuter DJ, Beeler DL, Rosenberg RD The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA. 91:1994;11,104-11,108.
29. Lok S, Kaushansky K, Holly RDet al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 369:1994;565-568.
30. Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest. 85:1990;1072-1084.
31. McDonald TP Thrombopoietin: its biology, purification, and characterization. Exp Hematol. 16:1988;201-205.
32. McDonald TP, Cottrell M, Clift R, Khouri JA, Long MD Studies on the purification of thrombopoietin from kidney cell culture medium. J Lab Clin Med. 106:1985;162-174.
33. McDonald TP, Clift R, Cottrell M A four-step procedure for the purification of thrombopoietin. Exp Hematol. 17:1989;865-871.
34. Metcalf D Hematopoietic regulators: redundancy or subtlety. Blood. 82:1993;3515-3523.
35. Metcalf D, Waring P, Nicola NA Actions of leukaemia inhibitory factor on megakaryocyte and platelet formation. Ciba Found Symp. 167:1992;174-197.
36. Methia N, Louache F, Vainchenker W, Wendling F Oligodeoxynucleotides anti-sense to the proto-oncogene c- mpl specifically inhibit in vitro megakaryocytopoiesis. Blood. 82:1993;1395-1401.
37. Neben TY, Loebelenz J, Hayes Let al. Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice. Blood. 81:1993;901-908.
38. Nichol J, Hokom M, Hornkohl Aet al. Megakaryocyte growth and development factor: analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy induced thrombocytopenia. J Clin Invest. 95:1995;2973-2978.
39. Ogawa M Differentiation and proliferation of hematopoietic stem cells. Blood. 81:1993;2844-2853.
40. Paul SR, Bennett F, Calvetti JAet al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA. 87:1990;7512-7516.
41. Segal GM, Stueve T, Adamson JW Analysis of murine megakaryocyte colony size and ploidy: effects of interleukin-3. J Cell Physiol. 137:1988;537-544.
42. Sitnicka E, Lin N, Priestley GVet al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood. 87:1996;4998-5005.
43. Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P Murine c- mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 12:1993;2645-2653.
44. Sohma Y, Akahori H, Seki Net al. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett. 353:1994;57-61.
45. Souyri M, Vigon I, Penciolelli J-F, Tambourin P, Wendling F A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell. 63:1990;1137-1147.
46. Sprugel KH, Humes JM, Grossmann A, Ren HP, Kaushansky K Recombinant thrombopoietin stimulates rapid platelet recovery in thrombocytopenic mice [abst]. Blood. 84(Suppl 1):1994;242a.
47. Stoffel R, Wiestner A, Skoda RC Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 87:1996;567-573.
48. Tayrien G, Rosenberg RD Purification and properties of a megakaryocyte stimulatory factor present both in the serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma. J Biol Chem. 262:1987;3262-3268.
49. Tsukada J, Misago M, Ogawa Ret al. Synergism between serum factor(s) and erythropoietin in inducing murine megakaryocyte colony formation: the synergistic factor in serum is distinct from interleukin-11 and stem cell factor (c- kit ligand). Blood. 81:1993;866-867.
50. Ulich TR, del Castillo J, Yin Set al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood. 86:1995;971-976.
51. Vadhan-Raj S, Burris H, Benjamin RSet al. Single dose therapy with recombinant thrombopoietin in patients receiving cytotoxic chemotherapy [abst]. Proc ASCO. 15:1996;24.
52. Vannucchi AM, Grossi A, Rafanelli D, Ferrini PR, Ramponi G Partial purification and biochemical characterization of human plasma thrombopoietin. Leukemia. 2:1988;236-240.
53. Vigon I, Mornon J-P, Cocault Let al. Molecular cloning and characterization of MPL, the human homologue of the v- mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA. 89:1992;5640-5644.
54. Vigon I, Florindo C, Fichelson Set al. Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene. 8:1993;2607-2615.
55. Vigon I, Dreyfus F, Melle Jet al. Expression of the c- mpl proto-oncogene in human hematologic malignancies. Blood. 82:1993;877-883.
56. Wendling F, Varlet P, Charon M, Tambourin P A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice. Virology. 149:1986;242-246.
57. Wendling F, Maraskovsky E, Debili Net al. c- mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature. 369:1994;571-574.
58. Zeigler FC, de Sauvage F, Widmer HRet al. In vitro megakaryocytopoietic and thrombopoietic activity of c- mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood. 84:1994;4045-4052.