Effects of noradrenaline on GnRH-secreting immortalized hypothalamic (GT1-7) neurons

Endocrine Journal

Volumn 44, Issue 1, 1997, Pages 73-78

  Uemura, Tsuguo ^a   Nishimura, Jun Ichi ^a   Yamaguchi, Hajime ^a   Hiruma, Hiromi ^a   Kimura, Fukuko ^a   Minaguchi, Hiroshi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Ca2+ mobilization; Gonadotropin releasing hormone (GnRH) neuron; Noradrenaline; Patch clamp

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ION; FURA 2 ACETOXYMETHYL ESTER; GONADORELIN; NORADRENALIN; PHENTOLAMINE; PROPRANOLOL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL IMMORTALIZATION; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; GONADORELIN RELEASE; HYPOTHALAMUS; NONHUMAN;

EID: 0030896872     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.44.73     Document Type: Article

References (15)

1. Weiner R, Findell P, Kordon C (1988) Role of classic and peptide neuromediators in the neuroendocrine regulation of LH and prolactin. In: Knobil E, Neill J (eds) The Physiology of Reproduction. Raven Press, New York: 1235-1281.
2. Ramirez V, Feder H, Sawyer C (1984) The role of brain catecholamines in the regulation of LH secretion: A critial inquiry. In: Martini L, Ganong W (eds) Frontiers in Neuroendocrinology. Raven Press, New York, vol. 7: 27-84.
3. Palkovits M (1981) Catecholamines in the hypothalamus: An anatomical review. Neuroendocrinology 33: 123-128.
4. Weiner R, Wetsel W, Goldsmith P, Martinez de la Escalera G, Windle J, Padula C, Choi A, Negro-Vilar A, Mellon P (1992) Gonadotropin-releasing hormone neuronal cell lines. Frontiers in Neuroendocrinology 13: 95-119.
5. Wray S, Hoffman G (1986) A developmental study of the quantitative distribution of LHRH neurons within the central nervous system of postnatal male and female rats. J Comp Neurol 252: 522-531.
6. 2+ in the selective enhancement of contractile responses of arteries from diabetic rats to noradrenaline. Can J Physiol Pharmacol 72: 1544-1551.
7. Nilsson H, Jensen PE, Mulvany MJ (1994) Minor role for direct adrenoceptor-mediated calcium entry in rat mesenteric small arteries. J Vasc Res 31: 314-321.
8. Krsmanovic L, Stojilkovic S, Mertz L, Tomic M (1993) Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc Natl Acad Sci USA 90: 3908-3912.
9. 2+]i and gonadotropin-releasing hormone secretion in immortalized hypothalamic GT1-7 neurons. Neuroendocrinology 59: 309-317.
10. Martinez de la Escalera G, Choi A, Weiner R (1992) Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: Intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 89: 1852-1855.
11. Wetsel W, Valenca M, Merchenthaler I, Liposits Z, Lopez FJ, Weiner RI, Mellon PL, Negro-Vilar A (1992) Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl acad Sci USA 89: 4149-4153.
12. Drouva S, Epelbaum J, Hery M, Tapia-Arancibia L, Laplamte E, Kordon C (1981) Ionic channels involved in the LHRH and SRIF release from rat mediobasal hypothalamus. Neuroendocrinology 32: 155-162.
13. 1-adrenergic and domaine (D1)-receptors coupled to adenylyl cyclase activation in GT1 gonadotropin-releasing hormone neurosecretory cells. Endocrinology 132: 682-688.
14. 1-Adrenergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: Stimulation of GnRH release via receptors positively coupled to adenylate cyclase. Endocrinology 131: 1397-1402.
15. Al-Damluji S, Krsmanovic L, Catt K (1993) High-affinity uptake of noradrenaline in postsynaptic neurones. Br J Pharmacol 109: 299-307.