The actions of polynucleotides on effector stage cloned murine T-helper cells differ in each subset and depend on antigen concentration

Journal of Nutrition

Volumn 127, Issue 3, 1997, Pages 411-417

  Jyonouchi, Harumi ^a   Sun, Sining ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

antibody secreting cells; cytokines; immune response; mice; polynucleotides; T helper cells

Indexed keywords

ANTIBODY; ANTIGEN; CD4 ANTIGEN; CYTOCHROME C; GAMMA INTERFERON; INTERLEUKIN 5; POLYNUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; HELPER CELL; HUMORAL IMMUNITY; INTERFERON PRODUCTION; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALIA; COLUMBA; MURINAE; ORYCTOLAGUS CUNICULUS;

EID: 0030896820     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.3.411     Document Type: Article

References (39)

1. Adjei, A. A., Takamine, F., Yokoyama, H., Chung, S. Y., Sato, L., Shinjo, S., Imamura, T.& Yamamoto, S. (1992) Effect of intraperitonally administered nucleoside-nucleotide on the recovery from methicillin-resistant Staphylococcus aureus strain 8985N infection in mice. J. Nutr. Sci. Vitaminol. 38: 221-225.
2. Biron, C. A. (1994) Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr. Opi. Immunol. 6: 530-538.
3. Boom, S. H., Liano, D. & Abbas, A. K. (1988) Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4-and interleukin 2-producing T cell clones on resting B lymphocytes. J. Exp. Med. 167: 1350-1363.
4. Bourgeade, M., Laurent-Winter, C., Besancon, F., Thang, M. N. &Mémet, S. (1993) Differential kinetics of polynucleotide expression and different biological activities in the human fibroblast response to dsRNA or interferon treatment. J. Interferon Res. 13:175-186.
5. Bradley, L. M., Duncan, D. D., Yoshimoto, K. & Swain, S. L. (1993) Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J. Immunol. 150: 3119-3130.
6. Carver, J. D. (1994) Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr. 124: 144S-148S.
7. Croft, M. (1994) Activation of naive, memory and effector T cells. Curr. Opi. Immunol. 6:431-437.
8. Decker T. (1992) Double-stranded RNA and interferon-α induce transcription through different molecular mechanisms. J. Interferon Res. 12: 445-448.
9. Dialynas, D. P., Wuan, Z. A., Sall, K. A., Pierres A., Quintans, J., Loken M. R., Pierres, M. & Fitch, F. W. (1983) Characterization of the murine T cell surface molecules, designated L3T4, identified by monoclonal antibody GK 1.5: Similarity of L3T4 to the human Leu-3/T4 molecules. J. Immunol. 131: 2445-2451.
10. Fanslow, W. C., Kulkarni, A. D., Van Buren, C. T. & Rudolph, F. B. (1990) Effect of nucleotide restriction and supplementation on resistance to experimental murine candidiasis. J. Parenter. Enteral. Nutr. 12: 49-52.
11. Garside, P. and Mowat, A. M. (1995) Polarization of Th-cell responses: a phylogenetic consequence of nonspecific immune defense? Immunol. Today 16: 220-223.
12. Hubbell, H. R., Boyer, J. E., Roane, P. & Burch, R. M. (1991) Cyclic AMP mediates the direct antiproliferative action of mismatched double-stranded RNA. Proc. Natl. Acad. Sci. U.S.A. 88: 906-910.
13. Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M. & Schwartz, R. H. (1987) Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc. Natl. Acad. Sci. U.S.A. 8: 5409-5413.
14. Jyonouchi, H. (1994) Nucleotide actions on humoral immune responses. J. Nutr. 124:1383-1435.
15. Jyonouchi, H., Hill, R. J. & Good, R. A. (1992) RNA/nucleotide enhances antibody production in vitro and is moderately mitogenic to murine spleen lymphocytes. Proc. Soc. Exp. Biol. Med. 200: 101-108.
16. Jyonouchi, H., Hill, R. J., Voss, R. M. & Ishii, E. (1993a) Immunomodulating actions of RNA and nucleotides on murine lymphocytes in vitro. Augmentation of antibody production to T dependent antigens and expansion of T helper cells. J. Nutr. Immunol. 2: 5-24.
17. Jyonouchi, H. & Sun, S. (1996) A nucleotide-free diet suppresses antigen-driven cytokine production by primed T cells: effects of supplemental nucleotides and dietary fatty acids. Nutrition. 12: 608-615.
18. Jyonouchi, H., Sun, S., Goodman, D., Yokoyama H. & Seiji S. (1995a) Dietary fatty acid modulates actions of nucleotides on humoral immune responses. Nutrition 11: 437-443.
19. Jyonouchi, H., Zhang-Shanbhag, L., Sun, S. & Yokoyama, H. (1995b) Polynucleotides can compensate for impaired T-dependent antibody production induced by a nucleotide-free diet both in vivo and in vitro in C57BL/6 mice, but mononucleotide/nucleoside mixture (OGVI) is effective only in vivo. J. Nutr. 125: 1578-1586.
20. Jyonouchi, H., Zhang, L. & Tomita, Y. (19935) RNA/nucleotides enhance in vitro antibody and immunoglobulin production to T-dependent antigen but do not facilitate polyclonal B cell activation in both normal and autoimmune-prone NZB strains of mice. J. Nutr. Immunol. 2: 5-22.
21. Jyonouchi, H., Zhang-Shanbhag, L., Tomita, Y. & Yokoyama, H. (1994) Nucleotide-free diet impairs T-helper cell functions for antibody production in normal C57BL/6 mice. J. Nutr. 124: 475-484.
22. Kulkarni, A. D., Fanslow, W. C., Rudolph, F. B. & Van Buren, C. T. (1986) Effect of dietary nucleotides on response to bacterial infections. J. Parenter. Enteral. Nutr. 10: 169-171.
23. Leleiko, N. S., Simmonds, B. A., Walsh, M., Kazlow, P., Rabinowitz, S. & Sterling, K. (1987) Tissue-specific gene expression results from a purine-and pyrimidine-free diet and 6-mercaptopurine in the rat small intestine and colon. Gastroenterology 93: 1014-1020.
24. Matzinger, P. & Fuchs, J. (1996) Beyond "self" and "non-self": immunity is a conversation, not a war. J. NIH Res. 8: 35-39.
25. Mémet, S., Besancoon, F., Bourgeade M. & Thang M. N. (1991) Direct induction of interferon-γ-and interferon-α/β-inducible genes by double-stranded RNA. J. Interferon Res. 11: 131-141.
26. Miller, R. A. (1991) Quantitation of functional T cells by limiting dilution. In: Current protocols inimmunology (Coligan, J. E., Kruisbeek, A. M., Bargulies, D. H., Shevach, E. M. & Strober, W., eds.), pp. 3.15.1-3.15.12, Green and Wiley-Interscience, New York.
27. Norsis, M. J. (1993) SPSS for Windows.™ SPSS Inc., Chicago, IL
28. Paul, W. E. & Seder, R. A. (1994) Lymphocyte responses and cytokines. Cell 76: 241-251.
29. Romagnani, S. (1994) Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12: 227-257.
30. Rudolph, F. B., Kulkarni, A. D., Fanslow, W. C., Pizzini, R. P., Kumar, S. & Van Buren, C. T. (1990) Role of RNA as a dietary source of pyrimidines and purines in immune function. Nutrition 6: 45-52.
31. Sonoda, T. & Tachibana, M. (1978) Metabolic rate of pyrimidines and purines in dietary nucleic acids ingested by mice. Biochim. Biophys. Acta 521: 55-66.
32. Sedgwick, J. D. & Holt, P. G. (1983) A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J. Immunol. Methods. 57: 301-309.
33. Snedecor, G. W. & Cochran, W. G. (1971) Statistical methods. Iowa State University Press, Ames, IA.
34. + T cells. Annu. Rev. Immunol. 12: 635-673.
35. Swain, S. L., Bradley, L., Croft, M., Tonkonogy, S., Atkins, G., Weinberg, A. D., Duncan, D. D., Hendrick, S. M., Dutton, R. W., & Huston, G. (1991) Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123: 115-144.
36. Tiwari, R. K., Kusari J. & Sen, G. C. (1987) Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors. EMBO J. 6: 3373-3378.
37. Tony, H. P., Phillips, N. E.& Parker, D. C. (1985) Role of membrane immunoglobulin (Ig) crosslinking in membrane Ig-mediated, major histocompatibility-restricted T cell-B cell cooperation. J. Exp. Med. 62: 1695-1708.
38. Van Buren, C. T., Kulkarni, A. D. & Rudolph, F. B. (1994) The role of nucleotides in adult nutrition. J. Nutr. 124: 160S-164S.
39. Weaver, C. T., Hawrylowicz, C. M. & Unanue, E. R. (1988) T-helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc. Natl. Acad. Sci. U.S.A. 85: 8181-8185.