Sterically crowded cyclohexanes - 9. Synthesis, conformation and dynamics of hexaspiro[2.0.4.0.2.0.4.0.2.0.4.0]tetracosane

Tetrahedron

Volumn 53, Issue 17, 1997, Pages 6011-6018

  Wulf, Karin ^a   Klages, Ulrich ^a   Rissom, Beate ^a   Fitjer, Lutz ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXANE DERIVATIVE; SPIRO COMPOUND;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0030896615     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)00289-5     Document Type: Article

References (22)

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2. For reviews on the conformation and dynamics of cyclohexanes, see: Mann, G. Z. Chem. 1990, 30, 1-9. Anderson, J. E. in The Chemistry of Alkanes and Cycloalkanes; Patai, S., Rappoport, Z., Eds.; Wiley: Chichester, 1992; Chapter 3. Eliel, E. L.; Wilen, S. H. Stereochemistry of Organic Compounds; Wiley: New York, 1994; Chapter 11. Conformational Behavior of Six-Membered Rings; Jurasti, E., Ed.; VCH Publishers: New York, 1995. For a review on nonchair conformations of cyclohexanes, see: Kellie, G. M.; Riddell, F. G. Top. Stereochem. 1974, 8, 225-269.
3. For reviews on the conformation and dynamics of cyclohexanes, see: Mann, G. Z. Chem. 1990, 30, 1-9. Anderson, J. E. in The Chemistry of Alkanes and Cycloalkanes; Patai, S., Rappoport, Z., Eds.; Wiley: Chichester, 1992; Chapter 3. Eliel, E. L.; Wilen, S. H. Stereochemistry of Organic Compounds; Wiley: New York, 1994; Chapter 11. Conformational Behavior of Six-Membered Rings; Jurasti, E., Ed.; VCH Publishers: New York, 1995. For a review on nonchair conformations of cyclohexanes, see: Kellie, G. M.; Riddell, F. G. Top. Stereochem. 1974, 8, 225-269.
4. For reviews on the conformation and dynamics of cyclohexanes, see: Mann, G. Z. Chem. 1990, 30, 1-9. Anderson, J. E. in The Chemistry of Alkanes and Cycloalkanes; Patai, S., Rappoport, Z., Eds.; Wiley: Chichester, 1992; Chapter 3. Eliel, E. L.; Wilen, S. H. Stereochemistry of Organic Compounds; Wiley: New York, 1994; Chapter 11. Conformational Behavior of Six-Membered Rings; Jurasti, E., Ed.; VCH Publishers: New York, 1995. For a review on nonchair conformations of cyclohexanes, see: Kellie, G. M.; Riddell, F. G. Top. Stereochem. 1974, 8, 225-269.
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16. 13C) for 72 h at room temperature (yield 98%).
17. c ≤ 113 K) and the frequency difference of the resonances of the pseudoaxial and pseudoequatorial carbon atoms (δν ≥ 10 Hz). For the methodology, see: Sandström, J. Dynamic NMR Spectroscopy; Academic Press: London, 1982; p 96.
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