Effect of endurance training on fatty acid metabolism during whole body exercise

Medicine and Science in Sports and Exercise

Volumn 29, Issue 5, 1997, Pages 635-639

  Martin III, Wade H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FFA OXIDATION; HUMANS; INTRAMUSCULAR TRIGLYCERIDES; PALMITATE KINETICS

Indexed keywords

FATTY ACID; PALMITIC ACID; TRIACYLGLYCEROL;

CONFERENCE PAPER; ENDURANCE; EXERCISE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HUMAN; KINETICS; MUSCLE MASS; MUSCLE METABOLISM; TRAINING;

EID: 0030896434     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-199705000-00008     Document Type: Conference Paper

References (41)

1. ARMSTRONG, D. T., R. STEELE, N. ALTSZULER, et al. Regulation of plasma free fatty acid turnover. Am. J. Physiol 201:9-15, 1961.
2. ARNER, P. Control of lipolysis and its relevance to development of obesity in man. Diab. Metab. Rev. 4:507-515, 1988.
3. ASTRAND, P. -O. and K. RODAHL. Textbook of Work Physiology: Physiological Bases of Exercise. New York: McGraw-Hill, 1986, p. 460.
4. BLOOM, S. R., R. H. JOHNSON, D. M. PARK, et al. Differences in the metabolism and hormonal response to exercise between racing cyclists and untrained individuals. J. Physiol. (Lond.) 258:1-18, 1976.
5. BROOKS, B., S. ARCH, and E. A. NEWSHOLME. Effects of hormones on the rate of the triacylglycerol/fatty acid substrate cycle in adipocytes and epididymal fat pads. FEBS Lett. 146:327-330, 1982.
6. CARLSON, L. A., L. -G. EKELUND, and S. O. FROBERG. Concentration of triglycerides, phospholipids and glycogen in skeletal muscle and of free fatty acids and β-hydroxybutyric acid in blood in man in response to exercise. Eur. J. Clin. Invest. 1:248-254, 1971.
7. 2-Aufnahme. Scand. Arch. Physiol. 81:180-189, 1939.
8. 2-blockade on exercise endurance and muscle metabolism in humans. J. Appl. Physiol. 66:548-555, 1989.
9. ESSEN, B., L. HAGENFELDT, and L. KAIJSER. Utilization of blood-borne and intramuscular substrates during continuous and intermittent exercise in man. J. Physiol. (Lond.) 265:489-506, 1977.
10. 14-labeled unesterified fatty acids in normal human subjects. J. Clin. Invest. 37:1504-1515, 1958.
11. FROBERG, S. O. and F. MOSSFELDT. Effect of prolonged strenuous exercise on the concentration of triglycerides, phospholipids and glycogen in muscle of man. Acta Physiol. Scand. 82:167-171, 1971.
12. GALBO, H. Hormonal and Metabolic Adaptation to Exercise. New York: Thieme-Stratton, Inc., 1983, pp. 14-45.
13. GALSTER, A. D., W. E. CLUTTER, P. E. CRYER. et al. Epinephrine plasma thresholds for lipolytic effects in man. J. Clin. Invest. 67:1729-1738, 1981.
14. GEORGE, J. C. and D. JYOTI. The lipid content and its reduction in the muscle and liver during long and sustained muscular activity. J. Anim. Morphol. Physiol. 2:31-37, 1955.
15. HARTLEY, L. H., J. W. MASON, R. P. HOGAN, et al. Multiple hormonal responses to graded exercise in relation to physical training. J. Appl. Physiol. 33:602-606, 1972.
16. HARTLEY, L. H., J. W. MASON, R. P. HOGAN, et al. Multiple hormone responses to prolonged exercise in relation to physical training. J. Appl. Physiol 33:607-610, 1972.
17. 14. J. Clin. Invest. 42:1054-1063, 1963.
18. HAVEL, R. J., L. A. CARLSON, L. -G. EKELUND, and A. HOLMGREN. Turnover rate and oxidation of different fatty acids in man during exercise. J. Appl. Physiol. 19:613-619, 1964.
19. 14C in man during prolonged heavy muscular exercise. J. Lipid Res. 8:366-373, 1967.
20. HAVEL, R. J., B. PERNOW, and N. L. JONES. Uptake and release of fatty acids and other substrates in the legs of exercising men. J. Appl. Physiol. 23:90-99, 1967.
21. HENRIKSSON, J. Training-induced adaptations of skeletal muscle and metabolism during submaximal exercise. J. Physiol. (Lond.) 270:661-665, 1977.
22. HURLEY, B. F., P. M. NEMETH, W. H. MARTIN III, et al. Muscle triglyceride utilization during exercise: effect of training. J. Appl. Physiol. 60:562-567, 1986.
23. KIENS, B., B. ESSEN-GUSTAVSSON, N. J. CHRISTENSEN, and B. SALTIN. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J. Physiol. (Lond.) 469:459-478, 1993.
24. LEWIS, S. F., W. F. TAYLOR, R. M. GRAHAM, et al. Cardiovascular responses to exercise as functions of absolute and relative work load. J. Appl. Physiol. 54:1314-1323, 1983.
25. LIN, E. C. C. Glycerol utilization and its regulation in mammals. Annu. Rev. Biochem 46:765-795, 1977.
26. MACKIE, B. G., G. A. DUDLEY, H. KACIUBA-USCILKO, and R. L. TERJUNG. Uptake of chylomicron triglycerides by contracting skeletal muscle in rats. J. Appl. Physiol. 49:851-855, 1980.
27. MARTIN, W. H., E. F. COYLE, M. JOYNER, et al. Effects of stopping exercise training on epinephrine-induced lipolysis in humans. J. Appl. Physiol. 56:845-848, 1984.
28. MARTIN, W. H. III, A. R. COGGAN, R. J. SPINA, et al. Effects of fiber type and training on β-adrenoceptor density in human skeletal muscle. Am. J. Physiol. 257:E736-E742, 1989.
29. MARTIN, W. H., G. P. DALSKY, B. F. HURLEY, et al. Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. Am. J. Physiol. 265:E708-E714, 1993.
30. 13C]leucine. Am. J. Physiol. 238:E473-E479, 1980.
31. MCGILVERY, R. W. Biochemistry: A Functional Approach. Philadelphia:W.B. Saunders Co., 1970, p. 516.
32. MOLE, P. A., L. B. OSCAI, and J. O. HOLLOSZY. Adaptation of muscle to exercise: increase in levels of palmityl CoA synthetase, carnitine palmityltransferase, and palmityl CoA dehydrogenase, and in the capacity to oxidize fatty acids. J. Clin. Invest. 50:2323-2330, 1971.
33. REITMAN, J., K. M. BALDWIN, and J. O. HOLLOSZY. Intramuscular triglyceride utilization by red, white, and intermediate skeletal muscle and heart during exhausting exercise. Proc. Soc. Exp. Biol. Med. 142:628-631, 1973.
34. ROMIJN, J. A., E. F. COYLE, L. S. SIDOSSIS, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265:E380-E391, 1993.
35. SALTIN, B. and P.-O. ASTRAND. Free fatty acids and exercise. Am. J. Clin. Nutr. 57(Suppl):752-758, 1993.
36. STANKIEWICZ-CHOROSZUCHA, B. and J. GORSKI. Effect of beta-adrenergic blockade on intramuscular triglyceride mobilization during exercise. Experientia 34:357-358, 1978.
37. TURCOTTE, L. P., E. A. RICHTER, and B. KIENS. Increased plasma FFA uptake and oxidation during exercise in trained vs. untrained humans. Am. J. Physiol. 262:E791-E799, 1992.
38. TERJUNG, R., B. G. MACKIE, G. A. DUDLEY, and H. KACIUBA-USCILKO. Influence of exercise on chylomicron triacylglycerol metabolism: plasma turnover and muscle uptake. Med. Sci. Sports Exerc. 15:340-347, 1983.
39. WILLIAMS, R. S. and T. BISHOP. Enhanced receptor-cyclase coupling and augmented catecholamine-stimulated lipolysis in exercising rats. Am. J. Physiol. 243:E345-E351, 1982.
40. WINDER, W. W., R. C. HICKSON, J. M. HAGBERG, et al. Training-induced changes in hormonal and metabolic responses to submaximal exercise. J. Appl. Physiol. 46:766-771, 1979.
41. WOLFE, R. R., S. KLEIN, F. CARRARO, and J. -M. WEBER. Role of triglyceride-fatty acid cycle in controlling fat metabolism during and after exercise. Am. J. Physiol. 258:E382-E389, 1990.