Ovine fetal leucine kinetics and protein metabolism during acute metabolic acidosis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 2 35-2, 1997, Pages

  Milley, J Ross ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

fetal growth; glucocorticoids; intrauterine growth retardation; protein accretion; proteolysis

Indexed keywords

GLUCOCORTICOID; LEUCINE;

AMINO ACID METABOLISM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FETUS; FETUS GROWTH; INTRAUTERINE GROWTH RETARDATION; METABOLIC ACIDOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SHEEP;

EID: 0030895248     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.2.e275     Document Type: Article

References (31)

1. Aftring, R. P., K. P. Block, and M. G. Buse. Leucine and isoleucine activate skeletal muscle branched-chain α-keto and dehydrogenase in vivo. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E599-E604, 1986.
2. Battaglia, F. C., and G. Meschia. Principle substrates of fetal metabolism. Physiol. Rev. 58: 499-527, 1978.
3. Bier, D. M. Intrinsically difficult problems: the kinetics of body proteins and amino acids in man. Diabetes Metab. Rev. 5: 111-132, 1989.
4. Block, K. P., W. B. Richmond, W. B. Mehard, and M. G. Buse. Glucocorticoid-mediated activation of muscle branched-chain α-keto acid dehydrogenase in vivo. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E396-E407, 1987.
5. DiGiacomo, J. E., and W. W. Hay, Jr. Regulation of placental glucose transfer and consumption by fetal glucose production. Pediatr. Res. 25: 429-434, 1989.
6. England, B. K., S. Greiber, W. E. Mitch, B. A. Bowers, W. J. Herring, M. McKean, R. G. Ebb, S. R. Price, and D. J. Danner. Rat muscle branched-chain ketoacid dehydrogenase activity and mRNAs increase with extracellular acidemia. Am. J. Physiol. 268 (Cell Physiol. 37): C1395-C1400, 1995.
7. Hay, W. W., Jr. Placental transport of nutrients to the fetus. Horm. Res. 42: 215-222, 1994.
8. Horber, F. F., C. M. Horber-Feyder, S. Krayer, W. F. Schwenk, and M. W. Raymond. Plasma reciprocal pool specific activity predicts that of intracellular free leucine for protein synthesis. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E385-E399, 1989.
9. Itzkowitz, J., E. F. Lagamma, and A. M. Rudolph. The effect of reducing umbilical blood flow on fetal oxygenation. Am. J. Obstet. Gynecol. 145: 813-818, 1983.
10. Jacobs, R., J. S. Robinson, J. A. Owens, J. Falconer, and M. E. D. Webster. The effect of prolonged hypobaric hypoxia on growth of fetal sheep. J. Dev. Physiol. 10: 97-112, 1988.
11. Loy, G. L., A. N. Quick, Jr., W. W. Hay, Jr., G. Meschia, F. C. Battaglia, and P. V. Fennessey. Fetoplacental deamination and decarboxylation of leucine. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E492-E497, 1990.
12. May, R. C., R. A. Kelly, and W. E. Mitch. Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. J. Clin. Invest. 77: 614-621, 1986.
13. May, R. C., R. A. Kelly, and W. E. Mitch. Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis. J. Clin. Invest. 79: 1099-1103, 1987.
14. McSherry, E., and R. C. Morris. Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis. J. Clin. Invest. 61: 509-527, 1978.
15. Milley, J. R. Protein synthesis during hypoxia in fetal lambs. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E519-E524, 1987.
16. Milley, J. R. Fetal protein metabolism. Semin. Perinatol. 13: 192-210, 1989.
17. Milley, J. R. Ovine fetal protein metabolism during decreased glucose delivery. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E525-E531, 1993.
18. Milley, J. R. Effects of insulin on ovine fetal leucine kinetics on protein metabolism. J. Clin. Invest. 93: 1616-1624, 1994.
19. Milley, J. R. Effects of increased cortisol concentration on ovine fetal leucine kinetics and protein metabolism. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E1114-E1122, 1995.
20. Milley, J. R., and J. C. Sweeley. High-performance liquid chromatographic measurement of leucine and α-ketoisocaproate in whole blood: application to fetal protein metabolism. J. Chromatogr. 613: 23-33, 1993.
21. Mitch, W. E., R. Medina, S. Grieber, R. C. May, B. K. England, S. R. Price, J. L. Bailey, and A. L. Goldberg. Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. J. Clin. Invest. 93: 2127-2133, 1994.
22. Moe, A. J. Placental amino acid transport. Am. J. Physiol. 268 (Cell Physiol. 37): C1321-C1331, 1995.
23. Olsen, C. An enzymatic flurometric micromethod for the determination of aceto-acetate, betahydroxy butyrate, pyruvate and lactate. Clin. Chim. Acta 33: 293-300, 1971.
24. Pardi, G., I. Cetin, A. M. Marconi, A. Lanfranchi, P. Bozzetti, E. Ferrazzi, M. Buscaglia, and F. C. Battaglia. Diagnostic value of blood sampling in fetuses with growth retardation. N. Engl. J. Med. 328: 692-696, 1993.
25. Paulone, M. E., D. I. Edelstone, and A. Shedd. Effects of maternal anemia on uteroplacental and fetal oxidative metabolism in sheep. Am. J. Obstet. Gynecol. 156: 230-236, 1987.
26. Price, S. R., B. K. England, J. L. Bailey, K. Van Vreede, and W. E. Mitch. Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle. Am. J. Physiol. 267 (Cell Physiol. 36): C955-C960, 1994.
27. Reaich, D., S. M. Channon, C. M. Scrimgeour, S. E. Daley, R. Wilkinson, and T. H. J. Goodship. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E230-E235, 1993.
28. Reaich, D., S. M. Channon, C. M. Scrimgeour, and T. H. J. Goodship. Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E735-E739, 1992.
29. Rodriguez, N. R., J. M. Miles, W. F. Schwenk, and M. W. Raymond. Effects of acute metabolic acidosis and alkalosis on leucine metabolism in conscious dogs. Diabetes 38: 847-853, 1989.
30. Soothill, P. W., K. H. Nicolaides, C. M. Bilardo, and S. Campbell. Relation of fetal hypoxia in growth retardation to mean blood velocity in the fetal aorta. Lancet 2: 1118-1120, 1986.
31. 2 kinetics. J. Dev. Physiol. 6: 359-365, 1984.