Sodium-hydrogen antiporter: Its possible role in the genesis of diabetic nephropathy

Nephrology Dialysis Transplantation

Volumn 12, Issue 4, 1997, Pages 643-645

  Trevisan, Roberto ^a   Viberti, Giancarlo ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIABETIC NEPHROPATHY; HEREDITY; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RENOVASCULAR HYPERTENSION; SHORT SURVEY;

DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; HUMANS; ION TRANSPORT; KIDNEY; KINETICS; PHENOTYPE; SODIUM-HYDROGEN ANTIPORTER;

EID: 0030894356     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.4.643     Document Type: Short Survey

References (21)

1. Viberti GC, Keen H, Wiseman MJ. Raised blood pressure in parents of proteinuric insulin-dependent diabetic patients. Br Med J 1987; 295: 575-577
2. Earle K, Walker J, Hill C, Viberti GC. Familial clustering of cardiovascular disease in patients with insulin dependent diabetes and nephropathy. N Engl J Med 1992; 326: 673-677
3. + exchanger isoforms. Am J Physiol 1995; 37: C:283-C296
4. + antiport activity in type 1(insulin-dependent) diabetic patients with nephropathy. Diabetologia 1990; 33: 371-77
5. Semplicini A, Mozzato MG, Sami B, Nosadini R, Fioretto P, Trevisan R, Pessina A, Crepaldi G, Dal Palú D. Sodium-hydrogen and lithium-sodium exchange in red cells of normotensive and hypertensive patients with insulin-dependent diabetes mellitus. Am J Hypertens 1989; 2: 174-77
6. Rosskopf D, Dusing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension 1993; 21: 607-617
7. Trevisan R, Li LK, Messent J, Tariq T, Earle KA, Walker JD, Viberti GC. Na/H antiport activity and cell growth in cultured skin fibroblasts of IDDM patients with nephropathy. Diabetes 1992; 41: 1239-1246
8. + antiport activity of cultured skin fibroblasts from diabetics. Kidney Int 1992; 42: 1184-1190
9. Lurbe A, Fioretto P, Mauer M, LaPointe MS, Battle D. Growth phenotype of cultured skin fibroblasts from IDDM patients with and without nephropathy and overactivity of the Na/H antiporter. Kidney Int 1996; 50: 1684-1693
10. Siczkowski M, Davies JE, Sweeney FP, Kofoed-Enevoldsen A, Ng LL. Na/H exchanger isoform-1 abundance in skin fibroblasts of type 1 diabetic patients with nephropathy. Metabolism 1995; 44: 791-795
11. Ng LL, Davies JE, Siczkowski M, Sweeney FP, Quinn PA, Krolewski B, Krolewski AS. Abnormal sodium-hydrogen antiporter phenotype and turnover of immortalized lymphoblasts from type 1 diabetic patients with nephropathy. J Clin Invest 1994; 93: 2750-2757
12. Trevisan R, Cipollina MR, Duner E, Trevisan M, Nosadini R. Abnormal sodium hydrogen antiport activity in cultured fibroblasts from NIDDM patients with hypertension and microalbuminuria. Diabetologia 1996; 39: 717-724
13. Trevisan R, Fioretto P, Mauer SM, Duner E, Cipollina MR, Trevisan M, Barbosa J, Nosadini R. Concordance for sodium-hydrogen antiport activity in insulin-dependent diabetic sibling pairs. Diabetologia 1995; 38 [Suppl. 1]: A230
14. Rosskopt D, Fromter E, Siffert W. Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. J Clin Invest 1993; 92: 2553-59.
15. Ng LL, Simmons D, Frighi V, Garrido MC, Bomford J. Effect of protein kinase C modulators on the leucocyte sodium-hydrogen antiport in type 1 diabetic subjects with albuminuria. Diabetologia 1990; 33: 278-284
16. + exchanger isoform 1 of immortalized lymphoblasts in diabetic nephropathy. Diabetes 1995; 44: 1180-1185
17. Williams B, Howard RL. Glucose-induced changes in Na/H antiport activity and gene expression in cultured vascular smooth muscle cells: role of protein kinase C. J Clin Invest 1994; 93: 2623-2631
18. + exchanger of immortalized lymphoblasts from type 1 diabetic patients with nephropathy. Diabetes 1995; 44: 382-388
19. Morocutti A, Earle KA, Sethi M, Piras G, Pal K, Richards D, Rodeman P, Viberti GC. Premature sensescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease. Kidney Int 1996; 50: 250-256
20. + antiporter by clustering and immobilizing integrin , independent of cell shape. Proc Natl Acad Sci USA 1991; 88: 7849-7853
21. Yip J, Trevisan R, Li LK, Viberti GC. Enhanced collagen synthesis in cultured skin fibroblasts from insulin-dependent diabetic patients with nephropathy. Diabetologia 1993; 36 [Suppl.1]: A11