Modulation of the immunostimulating effect of autologous tumor vaccine by anti-TGF-β antibody and interferon-α on murine MBT-2 bladder cancer

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 1073-1078

  Tzai, Tzong Shin ^a,b   Shiau, Ai Li ^a   Lin, Chein Sheng ^a   Wu, Chao Liang ^a   Lin, Johnny Shinn Nan ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Autologous tumor vaccine; Bladder cancer; Interferon ; Transforming growth factor

Indexed keywords

MESSENGER RNA; MONOCLONAL ANTIBODY; RECOMBINANT ALPHA2B INTERFERON; TRANSFORMING GROWTH FACTOR BETA; TUMOR VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CANCER; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN SECRETION; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR GROWTH; VACCINATION;

EID: 0030894248     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Tzai TS, Huben RP, Zaleskis G, Berleth ES, Ehrke MJ and Mihich E: Effect of perioperative chemoimmunotherapy with cyclophosphamide and autologous tumor vaccine in murine MBT-2 bladder cancer. J Urol 151: 1680-1686, 1994.
2. Fontana A, Hengartner H, de Tribolet N and Weber E: Glioblastoma cells release interleukin 1 and factors inhibiting interleukin-2-mediated effects. J Immunol 132: 1837-1844, 1984.
3. Lamm DL, Riggs DR, DeHaven JI and Bryner RW: Immunotherapy of murine bladder cancer by irradiated tumor vaccine. J Urol 145: 195-198, 1991.
4. Tzai TS, Lin JSN and Chow NH: Effects of chemoimmunotherapy with and without surgery in murine MBT-2 bladder tumor. Urol Int 53: 6-11, 1994.
5. Inge TH, Hoover SK, Susskind BM, Barrett SK and Bear HD: Inhibition of tumor-specific cytotoxic T-lymphocyte responses by transforming growth factor ß1. Cancer Res 52: 1386-1392, 1992.
6. Rook AH, Kehrl JH, Wakefield LM, Roberts AB, Sporn MB, Burlington DB, Lane HC and Fauci AS: Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of Interferon responsiveness. J Immunol 136: 3916-3920, 1986.
7. Nelson BJ, Ralph P, Green SJ and Nacy CA: Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1. J Immunol 146: 1849-1857, 1991.
8. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB and Fauci AS: Production of transforming growth factor ß by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163: 1037-1050, 1986.
9. Ellingsworth LR, Nakayama D, Segarini P, Dasch J, Carrillo P and Waegell W: Transforming growth factor-betas are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation. Cell Immunol 114: 41-54, 1988.
10. Kasid A, Bell GI and Director EP: Effects of transforming growth factor-beta on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells. J Immunol 141: 690-698, 1988.
11. Grimm EA, Crump WL 3d, Durett A, Hester JP, Lagoo-Deenadalayan S and Owen-Schaub LB: TGF-beta inhibits the in vitro induction of lymphokine-activated killing activity. Cancer Immunol Immunother 27: 53-58, 1988.
12. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Littoa LA, Falanga V, Kehrl JH and Fauchi AS: Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen forming in vitro. Proc Natl Acad Sci USA 83: 4167-4171, 1986.
13. Torre-Amione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL and Rowley DA: A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. Proc Natl Acad Sci USA 87: 1486-1490, 1990.
14. Tada T, Ohzeki S, Utsumi K, Takiuchi H, Muramatsu M, Li XF, Shimizu J, Fujiwara H and Hamaoka T: Transforming growth factor beta-induced inhibition of T-cell function: susceptibility difference in T-cells of various phenotypes and functions and its relevance to immunosuppression in the tumor bearing state. J Immunol 146: 1077-1082, 1991.
15. Arrick BA, Korc M and Derynek R: Differential regulation of expression of three transforming growth factor-beta species in human breast cancer cell lines by estradiol. Cancer Res 50: 299-303, 1990.
16. Hirte H and Clark DA: Generation of lymphokine-activated killer cells in human ovarian carcinoma ascitic fluid: identification of transforming growth factor-beta as a suppressive factor. Cancer Immunol Immunother 32: 296-302, 1991.
17. Lee G, Larry R, Ellingsworth LR, Gillis S, Wall R and Kincade PW: ß-Transforming growth factors are potential regulators of B lymphopoiesis. J Exp Med 166: 1290-1299, 1987.
18. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, ROSS R and Sporn MB: Expression and secretion of type ß transforming growth factor by activated human macrophages. Proc Natl Acad Sci USA 84: 6020-6024, 1987.