Metabolism and testicular toxicity of 1,3-dinitrobenzene in the rat: Evaluation of the stage-synchrony model

Reproductive Toxicology

Volumn 11, Issue 1, 1997, Pages 57-67

  Brown, Carl D ^a,b   Jacobson, Catherine F ^a   Miller, Marion G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

1,3 dinitrobenzene; metabolism in vivo; stage synchronized testis; testitular toxicity; vitamin A depletion

Indexed keywords

1,3 DINITROBENZENE; 3-DINITROBENZENE; DRUG METABOLITE; NITROBENZENE DERIVATIVE; RETINOL;

ADOLESCENT; ANIMAL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; MALE; METABOLISM; PATHOLOGY; RAT; RAT STRAIN; REPRODUCTIVE TOXICITY; RETINOL DEFICIENCY; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTIS; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALS; DINITROBENZENES; MALE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTIS; VITAMIN A DEFICIENCY;

ANIMALIA;

EID: 0030893906     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(96)00197-9     Document Type: Article

References (41)

1. Heindel JJ, Treinen KA. Physiology of the male reproductive system: endocrine, paracrine, and autocrine regulation. Toxicol Pathol. 1989;17:411-45.
2. Knobil E, Neill JD, eds. The physiology of reproduction. New York: Raven; 1988.
3. Mahesh VB, Dhindsa DS, Anderson E, Kalra SP. Regulation of ovarian and testicular function. New York: Plenum; 1987.
4. Skinner MK. Cell-cell interactions in the testis. Endocrinol Rev. 1991;12:45-77.
5. Leblond CP, Clermont Y. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann NY Acad Sci. 1952; 55:548-73.
6. Perey B, Clermont Y, Leblond CP. The wave of the seminiferous epithelium in the rat. Am J Anat. 1961;108:47-77.
7. Morales CR, Griswold MD. Retinol-induced stage synchronization in seminiferous tubules of the rat. Endocrinology. 1987;121:432-4.
8. Morales CR, Alcivar AA, Hecht NB, Griswold MD. Specific mRNAs in Sertoli and germinal cells of testes from stage synchronized rats. Mol Endocrinol. 1989;3:725-33.
9. Bartlett JMS, Spiteri-Grech J, Nieschlag E. Regulation of insulin-like growth factor I and stage-specific levels of epidermal growth factor in stage synchronized rai testes. Endocrinology. 1990;127: 747-58.
10. Meistrich ML, Trostle-Weige PK, van Beek MEAB. Separation of specific stages of spermatids from vitamin A-synchronized rat testes for assessment of nucleoprotein changes during spermiogenesis. Biol Reprod. 1994;51:334-44.
11. Bartlett JMS, Weinbauer GF, Nieschlag E. Quantitative analysis of germ cell numbers and relation to intratesticular testosterone following vitamin A-induced synchronization of spermatiogenesis in the rat. J Endocrinol. 1989;123:403-12.
12. Bartlett JMS, Weinbauer GF, Nieschlag E. Stability of spermatogenic synchronization achieved by depletion and restoration of vitamin A in rats. Biol Reprod. 1990;42:603-12.
13. Tsuruta JK, O'Brien DA, Griswold MD. Sertoli cell and germ cell cystatin C: stage-dependent expression of two distinct messenger ribonucleic acid transcripts in rat testes. Biol. Reprod. 1993;49: 1045-54.
14. Wang ZQ, Kim KH. Retinol differentially regulates male germ cell-associated kinase (mak) messenger ribonucleic acid expression during spermatogenesis. Biol Reprod. 1993;49:951-64.
15. Klaij IA, van Pelt AMM, Timmerman MA, Blok LJ, de Rooij DG, de Jong FH. Expression of inhibin subunit mRNAs and inhibin levels in the testes of rats with stage-synchronized spermatogenesis. J Endocrinol. 1994;141:131-41.
16. Creasy DM, Glynn JC, Gray TJB, Butler WH. A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol momomethyl ether in the rat. Exp Mol Pathol. 1985;43:321-36.
17. Blackburn DM, Gray AJ, Lloyd SC, Sheard CM, Foster PMD. A comparison of the effects of the three isomers of dinitrobenzene on the testis in the rat. Toxicol Appl Pharmacol. 1988;92:54-64.
18. Hess RA, Linder RE, Strader LF, Perreault SD. Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat I. Quantitative and qualitative histopathology of the testis. J Androl. 1988;9:327-42.
19. McEuen SF, Miller, MG. Metabolism and pharmacokinetics of 1,3-dinitrobenzene in the rat and the hamster. Drug Metab Disp. 1991;19:661-6.
20. Forssmann WG, Ito S, Weihe E, Aoki A, Dym M, Fawcett DW. An improved perfusion fixation method for the testis. Anat Rec. 1976; 188:307-14.
21. Brown CD, Forman CL, McEuen SF, Miller MG. Metabolism and testicular toxicity of 1,3-dinitrobenzene in rats of different ages. Fundam Appl Toxicol. 1994;23:439-46.
22. Renwick AG. Pharmacokineties in toxicology. In: Hayes AW, ed. Principles and methods of toxicology. 2nd ed. New York: Raven; 1989:835-78.
23. Gad SC, Weil CS. Statistics for toxicologists. In: Hayes AW, ed. Principles and methods of toxicology. 2nd ed. New York: Raven; 1989:435-83.
24. van Beek MEAB, Meistrich ML. A method for quantifying synchrony in testes of rats treated with vitamin deprivation and readministration. Biol Reprod. 1990;42:424-31.
25. van Beek MEAB, Meistrich ML. Stage-synchronized seminiferous epithelium in rats after manipulation of retinol levels. Biol Reprod. 1991;45:235-44.
26. Clermont Y, Harvey SC. Duration of the cycle of the seminiferous epithelium of normal, hypophysectomized and hypophysectomized-hormone treated albino rats. Endocrinology. 1965;76:80-9.
27. van Beek MEAB, Meistrich ML. Spermatogenesis in retinol-deficient rats maintained on retinoic acid. J Reprod Fertil. 1992; 94:327-36.
28. McEuen SF, Jacobson CF, Brown CD, Miller MG. Metabolism and testicular toxicity of 1,3-dinitrobenzene in the rat: Effect of route of administration. Fundam Appl Toxicol. 1995;28:94-9.
29. Linder RE, Strader LF, Barbee RR, Rehnberg GL, Perreault SD. Reproductive toxicity of a single dose of 1,3-dinitrobenzene in two ages of young adult male rats. Fundam Appl Toxicol. 1990;14: 284-98.
30. Evenson DP, Janca FC, Baer RK, Jost LK, Karabinus DS. Effect of 1,3-dinitrobenzene on prepubertal, pubertal, and adult mouse spermatogenesis. J Toxicol Environ Health. 1989;28:67-80.
31. Parvinen M, Wright WW, Phillips DM, Mather JP, Musto NA, Bardin CW. Spermatogenesis in vitro: completion of meiosis and early spermiogenesis. Endocrinology. 1983;112:1150-2.
32. Toppari J, Parvinen M. In vitro differentiation of rat seminiferous tubular segments from defined stages of the epithelial cycle: Morphologic and immunolocalization analysis. J Androl. 1985;6:334-43.
33. Linder RE, Hess RA, Perreault SD, Strader LF, Barbee RR. Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat I. Sperm quality, quantity, and fertilizing ability. J Androl. 1988;9:317-26.
34. Foster PMD, Sheard CM, Lloyd SC. 1,3-Dinitrobenzene: a Sertoli cell toxicant? In: Stefanini M, Conti M, Geremia R, Ziparo E, eds. Molecular and cellular endocrinology of the testes. Amsterdam: Elsevier; 1986:281-8.
35. Foster PMD, Lloyd SC, Prout MS. Toxicity and metabolism of 1,3-dinitrobenzene in rat testicular cell cultures. Toxicol In Vitro. 1987;1:31-7.
36. Cave DA, Foster PMD. Modulation of m-dinitrobenzene and m-nitrosonitrobenzene toxicity in rat Sertoli-germ cell cocultures. Fundam Appl Toxicol. 1990;14:199-207.
37. Chapin RE, Dutton SL, Ross MD, Sumrell BM, Lamb JC IV. Development of reproductive tract lesions in male F344 rats after treatment with dimethyl methylphosphonate. Exp Mol Pathol. 1984;41:126-40.
38. Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen CL, Rosenberger M, Lovey A, Grippo JF. A new pathway for vitamin A: understanding the pleiotropic effects of retinoids. Ann NY Acad Sci. 1992;669:70-86.
39. Chapin RE, Morgan KT, Bus JS. The morphogenesis of testicular degeneration induced in rats by orally administered 2,5-hexanedione. Exp Mol Pathol. 1983;38:149-69.
40. Boekelheide K, Rat testis during 2,5-hexanedione intoxication and recovery I. Dose response and the reversibility of germ cell loss. Toxicol Appl Pharmacol. 1988;92:18-27.
41. Somkuti SG, Lapadula DM, Chapin RE, Abou-Donia MB. Light and electron microscopic evidence of tri-o-cresyl phosphate (TOCP)-mediated testicular toxicity in Fischer 344 rats. Toxicol Appl Pharmacol. 1991;107:35-46.