Proliferative activity and p53 protein accumulation correlate with early invasive trend, and apoptosis correlates with differentiation grade in oesophageal squamous cell carcinomas

Virchows Archiv

Volumn 430, Issue 2, 1997, Pages 107-115

  Ohashi, Kenichi ^a   Nemoto, Tetsuo ^a   Eishi, Yoshinobu ^a   Matsuno, Atsumi ^a   Nakamura, Kyoichi ^a   Hirokawa, Katsuiku ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Ki 67; Oesophageal neoplasms; p53; Proliferative activity; Squamous cell carcinoma

Indexed keywords

MONOCLONAL ANTIBODY KI 67; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; KERATINIZATION; LABELING INDEX; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STROMA; TUMOR DIFFERENTIATION;

ANTIBODIES, MONOCLONAL; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; HUMANS; KI-67 ANTIGEN; PROGNOSIS; RETROSPECTIVE STUDIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030893535     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01008031     Document Type: Article

References (41)

1. Baba K, Kuwano H, Kitamura K, Sugimachi K (1993) Carcinomatous invasion and lymphocyte infiltration in early oesophageal carcinoma with special regard to the basement membrane. An immunohistochemical study. Hepatogastroenterology 40:226-231
2. Banks L, Matiashewski C, Crawford L (1986) Isolation of human-p53-specific monoclonal antibodies and their use in human p53 expression. Eur J Biochem 155:529-534
3. Billig H, Itsuko F, Hsueh AJW (1993) Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology 133:2204-2212
4. Endo M (1993) Endoscopie resection as local treatment of mucosal cancer of the esophagus. Endoscopy 25:672-674
5. Endo M, Yoshino K, Kawano T, Yano K (1993) Clinical evaluation of mucosal cancer of the esophagus: analysis of 1584 cases of superficial oesophageal cancer resected in Japan. In: Nabeya K, Hanaoka T, Nogami H (eds) Recent advances in diseases of the esophagus. Springer. New York Berlin Heidelberg, pp 540-545
6. Esrig D, Spruck III CH, Nichols PW, Chaiwun B, Steven K, Groshen S, Chen SC, Skinner DG, Jones PA, Cote RJ (1993) p53 nuclear protein accumulation correlates with mutation in the p53 gene, tumour grade, and stage in bladder cancer. Am J Pathol 143:1389-1397
7. Finlay CA, Hinds PW, Levine AJ (1989) The p53 proto-oncogene can act as a suppressor of transformation. Cell 57: 1083-1093
8. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119:493-501
9. Gerdes J (1990) Ki-67 and other proliferation markers useful for immunological diagnostic and prognostic evaluations in human malignancies. Semin Cancer Biol 1:199-206
10. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwabu, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715
11. Gerdes J, Stein H, Pileri S, Rivano MT, Gobbi M, Ralfkiaer E, Nielsen KM, Pallesen G, Bartels H, Palestro G, Delsol G (1987) Prognostic relevance of tumour-cell growth fraction in malignant non-Hodgkin's lymphomas. Lancet 11:448-449
12. Gerdes J, Li L, Schlueter C, Duchrow M, Wohlenberg C, Gerlach C, Stahmer I, Kloth S, Brandt E, Flad HD (1991) Immunohistochemical and molecular biologic characterization of cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol 138:867-873
13. Gerdes J, Becker MHG, Key G, Cattoretti G (1992) Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J Pathol (Lond) 168:85-86
14. Hollstein MC, Metcalf RA, Welsh JA, Montesano R, Harris CC (1990) Frequent mutation of the p53 gene in human oesophageal cancer. Proc Natl Acad Sci USA 87:9958-9961
15. Isola J, Visakorpi T, Holli K, Kallioniemi OP (1992) Association of overexpression of tumour suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients. J Natl Cancer Inst 84:1109-1117
16. Kasagi N, Gomyo Y, Shirai H, Tsujitani S, Ito H (1994) Apoptotic cell death in human gastric carcinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling. Jpn J Cancer Res 85:939-945
17. Kato H, Tachimori Y, Watanabe H (1990) Superficial oesophageal carcinoma: will early detection help? Cancer 66: 2319-2333
18. Kerr JFR, Wyllie AH, Curroe AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257
19. Key G, Becker MH, Baron B, Duchrow M, SchlŸter C, Flad HD, Gerdes J (1992) New Ki-67-equivalent murine monoclonal antibodies (MIB1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope. Lab Invest 68:629-636
20. Kitamura H, Kameda Y, Nakamura N, Nakatani Y, Inayama Y, Iida M, Noda K, Ogawa N, Shibagaki T, Kanisawa M (1995) Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma. Am J Pathol 146:876-887
21. Levine AJ, Momand J, Finlay CA (1991) The p53 tumour suppressor gene. Nature 351:453-456
22. McCall CA, Cohen JJ (1991) Programmed cell death in terminally differentiating keratinocytes: role of endogenous endonuclease. J Invest Dermatol 97:111-114
23. Nabeya K (1993) Early carcinoma of the esophagus. In: Nabeya K, Hanaoka T, Nogami H (eds) Recent advances in diseases of the esophagus. Springer, New York Berlin Heidelberg, pp 374-380
24. Nishimaki T, Tanaka O, Suzuki T, Aizawa K, Watanabe H, Muto T (1993) Tumour spread in superficial oesophageal cancer: histopathologic basis for rational surgical treatment. World J Surg 17:766-772
25. Obu M, Saegusa M, Okayasu I (1995) Apoptosis and cellular proliferation in ooesophageal squamous cell carcinomas: differences between keratinizing and nonkeratinizing types. Virchows Arch 427:271-276
26. Oren O (1992) p53: the ultimate tumour suppressor gene? FASEB J 6:3169-3176
27. Peracchia A, Ruol A, Bonavina L, Bardini R, Segalin A, Castoro C (1989) Early squamous cell carcinoma of the esophagus: diagnosis and management. Dig Surg 6:109-113
28. Saegusa M, Takano Y, Wakabayashi T, Okayasu I (1995) Apoptosis in gastric carcinomas and its association with cell proliferation and differentiation. Jpn J Cancer Res 86:743-748
29. Sasano H, Miyazaki S, Gooukon Y, Nishihira T, Sawai T, Nagura H (1992) Expression of p53 in human oesophageal cancer: an immunohistochemical study with correlation to proliferating cell nuclear antigen expression. Hum Pathol 23:1238-1243
30. Sugimachi K, Ohno S, Matsuda H, Mori M, Kuwano H (1988) Lugol-combined endoscopic detection of minute malignant lesions of the thoracic esophagus. Ann Surg 208:179-183
31. Terada T, Nakanuma Y (1992) Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. Cancer 70:591-598
32. Thor AD, Moore II DH, Edgerton SM, Kawasaki ES, Reihsaus E, Lynch HT, Marcus JN, Schwartz L, Chen LC, Mayall BH, Smith HS (1992) Accumulation of p53 tumour suppressor gene protein: an independent marker of prognosis in breast cancers. J Natl Cancer Inst 84:845-855
33. Tryggvason K, Hoyhtya M, Salo T (1987) Proteolytic degradation of extracellular matrix in tumour invasion. Biochim Biophys Acta 907:191-217
34. Tungekar MF, Gatter KC, Dunnill MS, Mason DY (1991) Ki67 immunostaining and survival in operable lung cancer. Histopathology 19:545-550
35. Ullrich SJ, Anderson CW, Mercer WE, Appella E (1992) The p53 tumour suppressor protein, a modulator of cell proliferation. J Biol Chem 267:15259-15262
36. Wagata T, Shibagaki I, Imamura M, Shimada Y, Toguchida J, Yandell DW, Ikenaga M, Toke T, Ishizaki K (1993) Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in oesophageal squamous carcinomas. Cancer Res 53:846-850
37. Wang LD, Hong JY, Qiu SL, Gao H, Yang CS (1993) Accumulation of p53 protein in human oesophageal precancerous lesions: a possible early biomarker for carcinogenesis. Cancer Res 53:1783-1787
38. WHO International Reference Centre for the Histological Classification of Gastro-oesophageal Tumours (1977) Definitions and explanatory notes of ooesophageal tumours. Histological typing of gastric and ooesophageal tumours (edited by Oota K). World Health Organization, Geneva, pp 33-36
39. Williams GT (1991) Programmed cell death: apoptosis and oncogenesis. Cell 65:1097-1098
40. Wintzer HO, Zipfel I, Schulte-Monting J, Hellerich U, Kleist S von (1991) Ki-67 immunostaining of human breast tumours and its relationship to prognosis. Cancer 67:421-428
41. Youssef EM, Matsuda T, Takada N, Osugi H, Higashino M, Kinoshita H, Watanabe T, Katsura Y, Wanibuchi H, Fukushima S (1995) Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus. Cancer 76:358-366