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Volumn 25, Issue 3, 1997, Pages 281-286

Enantioselective local disposition of semotiadil (R-enantiomer) and levosemotiadil (S-enantiomer) in perfused rat liver

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; LEVOSEMOTIADIL; SESAMODIL FUMARATE; UNCLASSIFIED DRUG;

EID: 0030893259     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (39)
  • 1
    • 0028818687 scopus 로고
    • 2+ channel antagonist, on the electrical activity of Langendorff-perfused guinea pig hearts in comparison with diltiazem, amlodipine and nifedipine
    • 2+ channel antagonist, on the electrical activity of Langendorff-perfused guinea pig hearts in comparison with diltiazem, amlodipine and nifedipine. Eur. J. Pharmacol. 286, 71-78 (1995).
    • (1995) Eur. J. Pharmacol. , vol.286 , pp. 71-78
    • Stark, G.1    Kasper, K.2    Stark, U.3    Miyawaki, N.4    Decrinis, M.5    Tritthart, H.A.6
  • 2
    • 0028920480 scopus 로고
    • 2+ level and force of contraction in porcine coronary arteries
    • 2+ level and force of contraction in porcine coronary arteries. Br. J. Pharmacol. 114, 1289-1295 (1995).
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 1289-1295
    • Kageyama, M.1    Yanagisawa, T.2    Taira, N.3
  • 4
    • 0027191835 scopus 로고
    • Mechanisms of the inhibitory action of semotiadil fumarate, a novel Ca antagonist, on the voltage-dependent Ca current in smooth muscle cells of the rabbit portal vein
    • N. Teramoto: Mechanisms of the inhibitory action of semotiadil fumarate, a novel Ca antagonist, on the voltage-dependent Ca current in smooth muscle cells of the rabbit portal vein. Jpn. J. Pharmacol. 61, 183-195 (1993).
    • (1993) Jpn. J. Pharmacol. , vol.61 , pp. 183-195
    • Teramoto, N.1
  • 5
    • 0025347283 scopus 로고
    • Tissue selectivity of the novel calcium antagonist sesamodil fumarate in isolated smooth muscles and cardiac muscles
    • K. Nishimura, N. Miyawaki, H. Yamauchi, and T. Iso: Tissue selectivity of the novel calcium antagonist sesamodil fumarate in isolated smooth muscles and cardiac muscles. Arzneimittelforschung 40, 244-248 (1990).
    • (1990) Arzneimittelforschung , vol.40 , pp. 244-248
    • Nishimura, K.1    Miyawaki, N.2    Yamauchi, H.3    Iso, T.4
  • 6
    • 0026007640 scopus 로고
    • SD-3211, a novel benzothiazine calcium antagonist, alone and in combination with a beta-adrenoceptor antagonist, produces antihypertensive effects without affecting heart rate and atrioventricular conduction in conscious renal hypertensive dogs
    • M. Kageyama, K. Nishimura, T. Takada, N. Miyawaki, and H. Yamauchi: SD-3211, a novel benzothiazine calcium antagonist, alone and in combination with a beta-adrenoceptor antagonist, produces antihypertensive effects without affecting heart rate and atrioventricular conduction in conscious renal hypertensive dogs. J. Cardiovasc. Pharmacol. 17, 102-107 (1991).
    • (1991) J. Cardiovasc. Pharmacol. , vol.17 , pp. 102-107
    • Kageyama, M.1    Nishimura, K.2    Takada, T.3    Miyawaki, N.4    Yamauchi, H.5
  • 8
    • 0343322333 scopus 로고
    • ++ antagonist, on vasopressin induced ST segment depression in rats
    • ++ antagonist, on vasopressin induced ST segment depression in rats. Jpn. J. Pharmacol. 55 (Suppl. I), 328p (1991).
    • (1991) Jpn. J. Pharmacol. , vol.55 , Issue.SUPPL. I
    • Mori, T.1    Irie, K.2    Ashida, S.3
  • 10
    • 0028890426 scopus 로고
    • Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilator action, on guinea-pig ventricular cells. Br
    • I. Kodama, R. Suzuki, K. Maruyama, and J. Toyama: Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilator action, on guinea-pig ventricular cells. Br. J. Pharmacol. 114, 503-509 (1995).
    • (1995) J. Pharmacol. , vol.114 , pp. 503-509
    • Kodama, I.1    Suzuki, R.2    Maruyama, K.3    Toyama, J.4
  • 11
    • 0026640527 scopus 로고
    • Calcium antagonistic and binding properties of semotiadil (SD-3211), a benzothiazine derivative assessed in cerebral and coronary arteries
    • K. Nakayama, K. Morimoto, Y. Nozawa, and Y. Tanaka: Calcium antagonistic and binding properties of semotiadil (SD-3211), a benzothiazine derivative assessed in cerebral and coronary arteries. J. Cardiovasc. Pharmacol. 20, 380-391 (1992).
    • (1992) J. Cardiovasc. Pharmacol. , vol.20 , pp. 380-391
    • Nakayama, K.1    Morimoto, K.2    Nozawa, Y.3    Tanaka, Y.4
  • 14
    • 0027059043 scopus 로고
    • Effects of a new antiarrhythmic drug, SD-3212, on canine ventricular arrhythmia models
    • A. Hirasawa, A. Haruno, T. Matsuzaki, and K. Hashimoto: Effects of a new antiarrhythmic drug, SD-3212, on canine ventricular arrhythmia models. Jpn. Heart J. 33, 851-861 (1992).
    • (1992) Jpn. Heart J. , vol.33 , pp. 851-861
    • Hirasawa, A.1    Haruno, A.2    Matsuzaki, T.3    Hashimoto, K.4
  • 15
    • 0025295250 scopus 로고
    • Antiarrhythmic effects of a benzothiazine derivative (SD-3211) and its stereoisomer (SA3212) in anaesthetized rats and isolated perfused rat hearts compared with bepridil
    • M. Fukuchi, T. Uematsu, S. Nagashima, and M. Nakashima: Antiarrhythmic effects of a benzothiazine derivative (SD-3211) and its stereoisomer (SA3212) in anaesthetized rats and isolated perfused rat hearts compared with bepridil. Naunyn-Schmiedeberg's Arch. Pharmacol. 341, 557-564 (1990).
    • (1990) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.341 , pp. 557-564
    • Fukuchi, M.1    Uematsu, T.2    Nagashima, S.3    Nakashima, M.4
  • 16
    • 0028790285 scopus 로고
    • SD-3212, a new class I and IV antiarrhythmic drug: A potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells
    • Y. Hara and H. Nakaya: SD-3212, a new class I and IV antiarrhythmic drug: a potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells. Br. J. Pharmacol. 116, 2750-2756 (1995).
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2750-2756
    • Hara, Y.1    Nakaya, H.2
  • 17
    • 0342352942 scopus 로고
    • Studies on the metabolic fate of semotiadil fumarate (SD-3211) (I): Absorption, distribution, metabolism and excretion after single administration to male rats
    • N. Morikawa, H. Takashina, H. Ibuki, H. Matsuoka, H. Yamaguchi, S. Miyagi, and M. Horiuchi: Studies on the metabolic fate of semotiadil fumarate (SD-3211) (I): absorption, distribution, metabolism and excretion after single administration to male rats. Xenobiot. Metab. Dispos. 7, 315-330 (1992).
    • (1992) Xenobiot. Metab. Dispos. , vol.7 , pp. 315-330
    • Morikawa, N.1    Takashina, H.2    Ibuki, H.3    Matsuoka, H.4    Yamaguchi, H.5    Miyagi, S.6    Horiuchi, M.7
  • 18
    • 0342787812 scopus 로고
    • Moment analysis for reaction chromatography
    • K. Yamaoka and T. Nakagawa: Moment analysis for reaction chromatography. J. Chromatogr. 117, 1-10 (1976).
    • (1976) J. Chromatogr. , vol.117 , pp. 1-10
    • Yamaoka, K.1    Nakagawa, T.2
  • 19
    • 0342787813 scopus 로고
    • Nonideal flow: Dispersion model (dispersed plug flow)
    • John Wiley & Sons, New York
    • O. Levenspiel: Nonideal flow: dispersion model (dispersed plug flow). In "Chemical Reaction Engineering," 2nd ed., pp. 272-290. John Wiley & Sons, New York, 1972.
    • (1972) "Chemical Reaction Engineering," 2nd Ed. , pp. 272-290
    • Levenspiel, O.1
  • 20
    • 0021798973 scopus 로고
    • Hepatic elimination - Dispersion model
    • M. S. Roberts and M. Rowland: Hepatic elimination - dispersion model. J. Pharm. Sci. 74, 585-587 (1985).
    • (1985) J. Pharm. Sci. , vol.74 , pp. 585-587
    • Roberts, M.S.1    Rowland, M.2
  • 21
    • 0022549973 scopus 로고
    • A dispersion model of hepatic elimination. 1. Formulation of the model and bolus considerations
    • M. S. Roberts and M. Rowland: A dispersion model of hepatic elimination. 1. Formulation of the model and bolus considerations. J. Pharmacokinet. Biopharm. 14, 227-260 (1986).
    • (1986) J. Pharmacokinet. Biopharm. , vol.14 , pp. 227-260
    • Roberts, M.S.1    Rowland, M.2
  • 22
    • 0024328692 scopus 로고
    • Two-compartment dispersion model for analysis of organ perfusion system of drugs by fast inverse Laplace transform (FILT)
    • Y. Yano, K. Yamaoka, Y. Aoyama, and H. Tanaka: Two-compartment dispersion model for analysis of organ perfusion system of drugs by fast inverse Laplace transform (FILT). J. Pharmacokinet. Biopharm. 17, 179-202 (1989).
    • (1989) J. Pharmacokinet. Biopharm. , vol.17 , pp. 179-202
    • Yano, Y.1    Yamaoka, K.2    Aoyama, Y.3    Tanaka, H.4
  • 23
    • 0025085601 scopus 로고
    • Evaluation of protein binding effect on local disposition of oxacillin in rat liver by a two-compartment dispersion model
    • Y. Yano, K. Yamaoka, T. Minamide, T. Nakagawa, and H. Tanaka: Evaluation of protein binding effect on local disposition of oxacillin in rat liver by a two-compartment dispersion model. J. Pharm. Pharmacol. 42, 632-636 (1990).
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 632-636
    • Yano, Y.1    Yamaoka, K.2    Minamide, T.3    Nakagawa, T.4    Tanaka, H.5
  • 24
    • 0025719936 scopus 로고
    • Effect of perfusion rate on the local disposition of cefixime in liver perfusion system based on two-compartment dispersion model
    • Y. Yano, K. Yamaoka, H. Yasui, and T. Nakagawa: Effect of perfusion rate on the local disposition of cefixime in liver perfusion system based on two-compartment dispersion model. Drug Metab. Dispos. 19, 1022-1027 (1991).
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 1022-1027
    • Yano, Y.1    Yamaoka, K.2    Yasui, H.3    Nakagawa, T.4
  • 25
    • 0025787031 scopus 로고
    • A two-compartment dispersion model describes the hepatic outflow profile of diclofenac in the presence of its binding protein
    • A. M. Evans, Z. Hussein, and M. Rowland: A two-compartment dispersion model describes the hepatic outflow profile of diclofenac in the presence of its binding protein. J. Pharm. Pharmacol. 43, 709-714 (1991).
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 709-714
    • Evans, A.M.1    Hussein, Z.2    Rowland, M.3
  • 26
    • 0026752823 scopus 로고
    • Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver
    • J. M. Diaz-Garcia, A. M. Evans, and M. Rowland: Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver. J. Pharmacokinet. Biopharm. 20, 171-193 (1992).
    • (1992) J. Pharmacokinet. Biopharm. , vol.20 , pp. 171-193
    • Diaz-Garcia, J.M.1    Evans, A.M.2    Rowland, M.3
  • 27
    • 0027936977 scopus 로고
    • Distribution kinetics of salicylic acid in the isolated perfused rat liver assessed using moment analysis and the two-compartment axial dispersion model
    • Z. Hussein, A. J. McLachlan, and M. Rowland: Distribution kinetics of salicylic acid in the isolated perfused rat liver assessed using moment analysis and the two-compartment axial dispersion model. Pharm. Res. 11, 1337-1345 (1994).
    • (1994) Pharm. Res. , vol.11 , pp. 1337-1345
    • Hussein, Z.1    McLachlan, A.J.2    Rowland, M.3
  • 28
    • 0028006590 scopus 로고
    • Local Disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver
    • M. Nishimura, K. Yamaoka, H. Yasui, S. Naito, and T. Nakagawa: Local Disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver. Biol. Pharm. Bull. 17, 1301-1304 (1994).
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 1301-1304
    • Nishimura, M.1    Yamaoka, K.2    Yasui, H.3    Naito, S.4    Nakagawa, T.5
  • 29
    • 0024642303 scopus 로고
    • A nonlinear least squares program, MULTI(FILT), based on fast inverse Laplace transform for microcomputers
    • Y. Yano, K. Yamaoka, and H. Tanaka: A nonlinear least squares program, MULTI(FILT), based on fast inverse Laplace transform for microcomputers. Chem. Pharm. Bull. 37, 1035-1038 (1989).
    • (1989) Chem. Pharm. Bull. , vol.37 , pp. 1035-1038
    • Yano, Y.1    Yamaoka, K.2    Tanaka, H.3
  • 30
    • 0019078457 scopus 로고
    • Numerical inversion of Laplace transform and some applications to wave optics
    • T. Hosono: Numerical inversion of Laplace transform and some applications to wave optics. Radio. Sci. 16, 1015-1019 (1981).
    • (1981) Radio. Sci. , vol.16 , pp. 1015-1019
    • Hosono, T.1
  • 32
    • 0014481730 scopus 로고
    • Equilibrium and kinetic properties of the Evans blue-albumin system
    • F. B. Freedman and J. A. Johnson: Equilibrium and kinetic properties of the Evans blue-albumin system. Am. J. Physiol. 216, 675-681 (1969).
    • (1969) Am. J. Physiol. , vol.216 , pp. 675-681
    • Freedman, F.B.1    Johnson, J.A.2
  • 33
    • 0025978924 scopus 로고
    • Synthesis and calcium antagonistic activities of fecal metabolites of a new calcium antagonist (+)-(R)-3,4-dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3,4-methylendioxy) phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine (SD-3211) in rats
    • M. Fujita, S. Ito, H. Suhara, H. Ibuki, and Y. Kawashima: Synthesis and calcium antagonistic activities of fecal metabolites of a new calcium antagonist (+)-(R)-3,4-dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3,4-methylendioxy) phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine (SD-3211) in rats. Yakugaku Zasshi 111, 59-64 (1991).
    • (1991) Yakugaku Zasshi , vol.111 , pp. 59-64
    • Fujita, M.1    Ito, S.2    Suhara, H.3    Ibuki, H.4    Kawashima, Y.5
  • 34
    • 0029117812 scopus 로고
    • Biliary metabolites of semotiadil fumarate in the rat
    • M. Nakaoka, K. Katoh, and H. Hakusui: Biliary metabolites of semotiadil fumarate in the rat. Xenobiotica 25, 847-855 (1995).
    • (1995) Xenobiotica , vol.25 , pp. 847-855
    • Nakaoka, M.1    Katoh, K.2    Hakusui, H.3
  • 35
    • 0343222419 scopus 로고    scopus 로고
    • Determination of unbound concentration of semotiadil (R-enantiomer) and levose-motiadil (S-enantiomer) in plasma protein solution by use of high-performance frontal analysis
    • in press
    • M. E. Rodriguez, A. Shibukawa, K. Ueda, and T. Nakagawa: Determination of unbound concentration of semotiadil (R-enantiomer) and levose-motiadil (S-enantiomer) in plasma protein solution by use of high-performance frontal analysis. J. Pharm. Biol. Anal. in press.
    • J. Pharm. Biol. Anal.
    • Rodriguez, M.E.1    Shibukawa, A.2    Ueda, K.3    Nakagawa, T.4
  • 36
    • 0001244133 scopus 로고
    • A linear method for determining liver sinusoidal and extravascular volumes
    • C. A. Goresky: A linear method for determining liver sinusoidal and extravascular volumes. Am. J. Physiol. 204, 626-640 (1963).
    • (1963) Am. J. Physiol. , vol.204 , pp. 626-640
    • Goresky, C.A.1
  • 37
    • 0022652710 scopus 로고
    • Effect of albumin on hepatic uptake of warfarin in normal and analbuminemic mutant rats: Analysis by multiple indicator dilution method
    • S. C. Tsao, Y. Sugiyama, Y. Sawada, S. Nagase, T. Iga, and M. Hanano: Effect of albumin on hepatic uptake of warfarin in normal and analbuminemic mutant rats: analysis by multiple indicator dilution method. J. Pharmacokinet. Biopharm. 14, 51-64 (1978).
    • (1978) J. Pharmacokinet. Biopharm. , vol.14 , pp. 51-64
    • Tsao, S.C.1    Sugiyama, Y.2    Sawada, Y.3    Nagase, S.4    Iga, T.5    Hanano, M.6
  • 38
    • 0025120462 scopus 로고
    • Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination. 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate
    • M. S. Roberts, S. Fraser, A. Wagner, and L. McLeod: Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination. 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate. J. Pharmacokinet. Biopharm. 18, 209-234 (1990).
    • (1990) J. Pharmacokinet. Biopharm. , vol.18 , pp. 209-234
    • Roberts, M.S.1    Fraser, S.2    Wagner, A.3    McLeod, L.4
  • 39
    • 0001394264 scopus 로고
    • Apparent volume of distribution
    • Marcel Dekker, New York
    • M. Gibaldi and D. Perrier: Apparent volume of distribution. In "Pharmacokinetics," 2nd ed., pp. 199-219. Marcel Dekker, New York, 1982.
    • (1982) "Pharmacokinetics," 2nd Ed. , pp. 199-219
    • Gibaldi, M.1    Perrier, D.2


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