The role of insulin in age-related sex differences of cardiovascular risk profile and morbidity

Atherosclerosis

Volumn 130, Issue 1-2, 1997, Pages 183-189

  Willeit, Johann ^a   Kiechl, Stefan ^a   Egger, Georg ^b   Oberhollenzer, Martin ^b   Oberhollenzer, Friedrich ^b   Muggeo, Michele ^c   Poewe, Werner ^a   Bonora, Enzo ^c  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF VERONA   (Italy)

^c BRUNECK HOSPITAL   (Italy)

Author keywords

ageing; insulin; menopause; metabolic syndrome; sex hormones; vascular risk factors

Indexed keywords

INSULIN; SEX HORMONE;

ADULT; AGED; AGING; ARTICLE; ATHEROSCLEROSIS; FEMALE; HUMAN; MENOPAUSE; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; AGED; AGING; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; FEMALE; HUMANS; INSULIN; LIPIDS; MALE; MENOPAUSE; MIDDLE AGED; RISK FACTORS; SEX CHARACTERISTICS;

EID: 0030892840     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(96)06038-8     Document Type: Article

References (37)

1. Kannel WB, Hjortland MC, McNamara PM, Gordon T. Menopause and risk of cardiovascular disease: The Framingham Study. Ann Intern Med 1976;85:447.
2. Willeit J, Kiechl S. Prevalence and risk factors of asymptomatic extracranial carotid artery atherosclerosis: a population-based study. Arterioscler Thromb 1993;13:661.
3. Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factors for coronary heart disease. N Engl J Med 1989;321:641.
4. Walton C, Godsland IF, Proudler AJ, Wynn V, Stevenson JC. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest 1993;28:466.
5. Proudler AJ, Felton CV, Stevenson JC. Ageing and the response of plasma insulin, glucose and C-peptide concentrations to intravenous glucose in postmenopausal women. Clin Sci 1992;83:489.
6. Laakso M. How good a marker is insulin level for insulin resistance? Am J Epidemiol 1993;137:959.
7. Hales CN, Randle PJ. Immunoassay of insulin with insulin antibody precipitate. Biochem J 1963;88:137.
8. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge. Clin Chem 1972;18:499.
9. Norusis MJ. User's Guide SPSS-X. Chicago, Ill, SPSS Inc, 1990.
10. Razay G, Heaton KW, Bolton CH. Coronary heart disease risk factors in relation to the menopause. Q J Med 1992;85:889.
11. Manolio TA, Savage PJ, Burke GL, Liu KA, Wagenknecht LE, Sidney S, Jacobs DR, Roseman JM, Donahue RP, Oberman A. Association of fasting insulin with blood pressure and lipids in young adults. The CARDIA Study. Arteriosclerosis 1990;10:430.
12. Folsom AR, Eckfeldt JH, Weitzman S, Ma J, Chambless LE, Barnes RW, Cram KB, Hutchinson RG. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Stroke 1994;25:66.
13. Donahue RP, Orchard TJ, Becker DJ, Kuller LH, Drash AL. Sex differences in the coronary heart disease risk profile: a possible role for insulin. Am J Epidemiol 1987;125:650.
14. Mykkänen L, Kuusisto J, Haffner SM, Pyörälä K, Laakso M. Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects. Arterioscler Thromb 1994;14:518.
15. Stevenson JC, Crook D, Godsland IF, Collins P, Whitehead MI. Hormone replacement therapy and the cardiovascular system. Nonlipid effects. Drugs 1994;47:35.
16. Barrett-Connor E, Laakso M. Ischemic heart disease risk in postmenopausal women: effects of estrogen use on glucose and insulin levels. Arteriosclerosis 1990;10:531.
17. Nabulsi AA, Folsom AR, White A, Patsch W, Heiss G, Wu KK, Szklo M. Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. N Engl J Med 1993;328:1069.
18. Shoupe D, Lobo RA. The influence of androgens on insulin resistance. Fert Steril 1984;41:385.
19. Woodard TL, Burghen GA, Kitabchi AE. Glucose intolerance and insulin resistance in aplastic anemia treated with oxymethalone. J Clin Endocrinol Metab 1981;53:905.
20. Peiris AN, Aiman EJ, Drucker WD, Kissebah AH. The relative contributions of hepatic and peripheral tissues to insulin resistance in hyperandrogenic women. J Clin Endocrinol Metab 1989;68:715.
21. Haffner SM, Katz MS, Stern MP, Dunn JF. Association of decreased sex hormone binding globulin and cardiovascular risk factors. Arteriosclerosis 1989;9:136.
22. Adams MR, Williams JK, Kaplan JR. Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness. Arterioscler Thromb Vase Biol 1995;15:562.
23. Khaw KT, Barrett-Connor E. Fasting plasma glucose levels and endogenous androgens in nondiabetic postmenopausal women. Clin Sci Colch 1991;80:199.
24. Soler JT, Folsom AR, Kaye SA, Prineas RJ. Associations of abdominal adiposity, fasting insulin, sex hormone binding globulin, and estrone with lipids and lipoproteins in postmenopausal women. Atherosclerosis 1989;79:21.
25. Haffner SM, Valdez RA, Mykkänen L, Stern MP, Katz MS. Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 1994;43:599.
26. Fink RI, Kolterman OG, Griffin J, Olefsky JM. Mechanisms of insulin resistance in aging. J Clin Invest 1983;71:1523.
27. Reaven GM, Reaven EP. Effects of age on various aspects of glucose and insulin metabolism. Mol Cell Biochem 1980;31:37.
28. Kimmerling G, Javorski WC, Reaven GM. Aging and insulin resistance in a group of non-obese male volunteers. J Am Geriatr Soc 1977;25:349.
29. Ivy JL, Young JC, Craig BW, Kohrt WM, Holloszy JO. Ageing, exercise and food restriction: effects on skeletal muscle glucose uptake. Mech Ageing Dev 1991;61:123.
30. Boden G, Chen X, DeSantis RA, Kendrick Z. Effects of age and body fat on insulin resistance in healthy men. Diabetes Care 1993;16:728.
31. Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO. Insulin resistance in aging is related to abdominal obesity. Diabetes 1993;42:273.
32. Kalant N, Leibovici D, Leibovici T, Fukushima N. Effect of age on glucose utilization and responsiveness to insulin in forearm muscle. Am Geriatr Soc 1980;28:204.
33. Gumbiner B, Polonski KS, Beltz WF, Wallace P, Brechtel G, Fink RI. Effects of aging on insulin secretion. Diabetes 1989;38:1549.
34. Pacini G, Beccaro F, Valerio A, Nosadini R, Crepaldi G. Reduced beta-cell secretion and insulin hepatic extraction in healthy elderly subjects. J Am Geriatr Soc 1990;38:1283.
35. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595.
36. Haffner SM, Valdez RA, Hazuda HH, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes 1992;41:715.
37. Neaton JD, Kuller LH, Wentworth D, Borthani NO. Total and cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for five years. Am Heart J 1984;108:759.