Psychological effects of continuation versus discontinuation of hormone replacement therapy by estrogen implants: A placebo-controlled study

Journal of Psychosomatic Research

Volumn 42, Issue 2, 1997, Pages 177-186

  Pearce, Jane ^a,c   Hawton, Keith ^a   Blake, Fiona ^a   Barlow, David ^b   Rees, Margaret ^b   Fagg, Joan ^a   Keenan, John ^b  

^a WARNEFORD HOSPITAL   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c OXFORD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Estrogen hormone replacement therapy; Menopause; Placebo; Psychiatric disorder; Psychological symptoms

Indexed keywords

ESTRADIOL; ESTROGEN;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; ESTROGEN THERAPY; FEMALE; FLUSHING; HUMAN; INTERVIEW; MENOPAUSAL SYNDROME; MENTAL DISEASE; OVARIECTOMY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SELF CONCEPT; SOCIAL PSYCHOLOGY; TIME;

EID: 0030892483     PISSN: 00223999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3999(96)00265-6     Document Type: Article

References (25)

1. Moore B, Gustafson R, Studd J. Experience of a national health service menopause clinic. Curr Med Res Opin 1975;3(suppl 3):42-55.
2. Hay AG, Bancroft J, Johnstone EC. Affective symptoms in women attending a menopause clinic. Br J Psychiatry 1994;164:513-516.
3. Studd J, Chakravarti S, Oram D. The climacteric. In: Greenblatt W, Studd, J, eds. Clinics in obstetrics and gynecotogy. (vol 4). Toronto: WB Saunders; 1977:3-29.
4. Oldenhave A, Jaszmann LJB, Everaerd WTAM, Haspels AA. Hysterectomised women with ovarian conservation report more severe climacteric complaints than do normal climacteric women of similar age. Am J Obstet Gynecol 1993;168:765-771.
5. Pearce J, Hawton K, Blake F. Psychological and sexual symptoms associated with the menopause and the effects of hormone replacement therapy. Br J Psychiatry 1995;167:163-173.
6. Sherwin BB, Gelfand MM. Sex steroids and affect in the surgical menopause; a double-blind, cross-over study. Psychoneuroendocrinology 1985;10:325-335.
7. Sherwin BB. Affective changes with oestrogen and androgen replacement therapy in surgically menopausal women. J Affect Dis 1988;14:177-187.
8. Campbell S. Double blind psychometric studies on the effects of natural oestrogens on postmenopausal women. In: Campbell S, ed. The management of the menopause and post-menopausal years. Lancaster: MTP Press,;1976:149-158.
9. Belchetz P. Hormone replacement treatment. BMJ 1989;67:1467.
10. Barlow DH, Abdalla HI, Roberts ADG, Al Assawi F, Leggate I, Hart DM. Long-term hormone implant therapy - hormonal and clinical effects. Obstetr Gynaecol 1986;67:321-325.
11. Gangar K, Cust M, Whitehead MI, Symptoms of oestrogen deficiency associated with supraphysiological plasma oestradiol concentrations in women with oestradiol implants. BMJ 1989;299:601-602.
12. Bewley S, Bewley TH. Drug dependence with oestrogen replacement therapy. Lancet 1992;339: 290-291.
13. Greene JG. Methodological issues in climacteric research. In: Greene JG, ed. Social and psychological origins of the climacteric syndrome. Aldershot: Gower: 1984:164-185.
14. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatrica Scand 1983;67:361-370.
15. Broadbent DE, Cooper PJ, Fitzgerald PF, Parkes KR. The cognitive failures questionnaire (CFQ) and its correlates. Br J Clin Psychol 1982;21:1-16.
16. Robson P. Development of a new self report questionnaire to measure self esteem. Psychol Med 1989;19:513-518.
17. Wing JK, Cooper JE, Sartorius N. The measurements and classification of psychiatric symptoms. Cambridge: Cambridge University Press; 1974.
18. SPSS Inc. SPSSX users' guide. New York: McGraw-Hill; 1983.
19. Phillips SM, Sherwin BB. Effects of oestrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 1992; 17:485-495.
20. Dennerstein L, Burrows GD, Hyman GJ, Sharpe K. Hormone therapy and affect. Maturitas 1979;1:247-259.
21. Mayou R, Hawton K. Psychiatric disorder in the general hospital. Br J Psychiatry, 1986;149:172-190.
22. Chakravarti S, Collins RP, Thom MH, Studd JWW. Relationship between plasma hormone profiles, symptoms, and response to oestrogen treatment in women approaching the menopause. BMJ 1979;1:983-985.
23. Alder EM. The effect of hormone replacement therapy on psychological symptoms. In: Wijma K, van Schoultz B, eds. Reproductive life. Carnforth: Parthenon; 1992:359-364.
24. Garnett T, Studd JWW, Henderson A, Watson N, Savvas M, Leather A. Hormone implants and tachyphylaxis. Br J Obstet Gynaecol 1990;97:917-921.
25. Pocock SJ. Clinical trials: A practical approach. Chichester: Wiley; 1983.