Quantitative evaluation of pharmacological effects and adverse effects based on receptor occupancy theory

Yakugaku Zasshi

Volumn 117, Issue 2, 1997, Pages 65-90

  Sawada, Yasufumi ^a   Yamada, Yasuhiko ^b   Iga, Tatsuji ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

dosage regimen; drug; pharmacokinetics; prediction; receptor occupancy theory; ternary complex model

Indexed keywords

ACEBUTOLOL; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ATENOLOL; BEFUNOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CIMETIDINE; CLENBUTEROL; FAMOTIDINE; FORMOTEROL; HISTAMINE H2 RECEPTOR ANTAGONIST; MABUTEROL; METOPROLOL; MIDODRINE; NEUROLEPTIC AGENT; NEW DRUG; ORCIPRENALINE; OXPRENOLOL; PINDOLOL; PIRBUTEROL; PROCATEROL; PROPRANOLOL; RANITIDINE; SALBUTAMOL; SULFONYLUREA DERIVATIVE; TERBUTALINE; TIMOLOL; TULOBUTEROL; UNINDEXED DRUG;

DISSOCIATION CONSTANT; DOSE TIME EFFECT RELATION; DRUG RECEPTOR BINDING; HUMAN; MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR OCCUPANCY; REVIEW; THEORY; TOPICAL DRUG ADMINISTRATION; TOXICITY TESTING;

EID: 0030891889     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi1947.117.2_65     Document Type: Review

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