Nonideal mixing and phase separation in phosphatidylcholine- phosphatidic acid mixtures as a function of acyl chain length and pH

Biophysical Journal

Volumn 72, Issue 5, 1997, Pages 2196-2210

  Garidel, Patrick ^b   Johann, Christof ^b   Blume, Alfred ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; MISCIBILITY; PH; SIMULATION; THERMODYNAMICS;

EID: 0030891869     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78863-5     Document Type: Article

References (70)

1. Ali, S., H.-N. Lin, R. Bitman, and C.-H. Huang. 1989. Binary mixtures of saturated and unsaturated mixed-chain phosphatidylcholines. A differential scanning calorimetry study. Biochemistry. 28:522-528.
2. Almeida, P. P. F., and W. L. C. Vaz. 1995. Lateral diffusion in membranes. In Structure and Dynamics of Membranes. R. Lipowsky and E. Sackmann, editors. Elsevier Science, Amsterdam. 305-357.
3. Almeida, P. F. F., W. L. C. Vaz, and T. E. Thompson. 1993. Percolation and fusion in three-component bilayers: effect of cholesterol on an equimolar mixture of two phospatidylcholines. Biophys. J. 64:399-412.
4. Benga, G., and R. P. Holmes. 1984. Interactions between components in biological membranes and their implications for membrane function. Prog. Biophys. Mol. Biol. 43:195-257.
5. Berclaz, T., and M. Geoffroy. 1984. Spin-labeling study of phosphatidylcholine-cardiolipin binary mixtures. Biochemistry. 23:4033-4037.
6. Berclaz, T., and H. McConnell. 1981. Phase equilibria in binary mixtures of dimyristoylphosphatidylcholine and cardiolipin. Biochemistry. 23: 635-640.
7. Blume, A. 1988. Applications of calorimetry to lipid model membranes. In Physical Properties of Biological Membranes and Their Functional Implications. C. Hidalgo, editor. Plenum Publishing Corporation, New York.
8. Blume, A. 1991. Biological Calorimetry: Membranes. Themochim. Acta. 193:299-347.
9. Blume, A., and H. J. Eibl. 1979. The influence of charge on bilayer membranes. Calorimetric investigations of phosphatidic acid bilayers. Biochim. Biophys. Acta. 558:13-21.
10. Blume, A., and J. Tuchtenhagen. 1992. Thermodynamics of ion binding to phospholipid bilayers. Titration calorimetry of the heat of dissociation of DMPA. Biochemistry. 31:4636-4642.
11. Brumbaugh, E. E., and C. Huang. 1992. Parameter estimation in binary mixtures of phospholipids. Methods Enzymol. 210:521-539.
12. Carruthers, A., and D. L. Melchior. 1983. Studies of the relationship between bilayer water permeability and bilayer physical state. Biochemistry. 22:5797-5807.
13. Chen, S. C., J. M. Sturtevant, and B. J. Gaffney. 1980. Scanning calorimetric evidence for a third phase transition in phosphatidylcholine. Proc. Natl. Acad. Sci. USA. 77:5060-5063.
14. Cronan, J. E., and E. P. Gelman. 1975. Physical properties of membrane lipids: biological relevance and regulation. Bacteriol. Rev. 39:232-256.
15. Eibl, H., and A. Blume. 1979. The influence of charge on phosphatidic acid bilayer membranes. Biochim. Biophys. Acta. 553:476-488.
16. Galla, H. J., and E. Sackmann. 1975. Chemically induced phase separation in mixed vesicles containing phosphatidic acid. An optical study. J. Am. Chem. Soc. 97:4114-4120.
17. 2H-NMR-und FT-IR-Methoden. Diploma thesis. University of Kaiserslautern, Kaiserslautern, Germany.
18. Glaser, M. 1993. Lipid domains in biological membranes. Curr. Opin. Struct. Biol. 3:475-481.
19. Guggenheim, E. A. 1944. Statistical thermodynamics of mixtures with zero energies of mixing. Proc. R. Soc. Lond. Ser. A. 183:203-212.
20. Hahn, F. L., and R. Luckhaus. 1956. Ein vorzügliches Reagenz zur kolorimetrischen Bestimmung von Phosphat und Arsenat. Z. Anal. Chem. 149:172-177.
21. Hildebrandt, H. J. 1929. Solubility (XII). Regular solutions. J. Am. Chem. Soc. 51:66-80.
22. Hinderliter, A. K., J. Huang, and G. W. Feigenson. 1994. Detection of phase separation in fluid phosphatidylserine/phosphatidylcholine mixtures. Biophys. J. 67:1906-1911.
23. 2+-induced phase separations in phosphatidylserine-containing lipid vesicles. Biochemistry. 21:1055-1061.
24. Hoekstra, D. 1982b. Role of lipid phase separations and membrane hydration in phospholipid vesicle fusion. Biochemistry. 21:2833-2840.
25. Huang, J., and G. W. Feigenson. 1993. Monte Carlo simulation of lipid mixtures: finding phase separation. Biophys. J. 65:1788-1794.
26. Inoue, T., T. Tasaka, and R. Shimozawa. 1992. Miscibility of binary phospholipid mixtures under hydrated and unhydrated conditions. I. Phosphatidic acids with mixtures of different acyl chain length. Chem. Phys. Lipids. 63:203-212.
27. Jacobson, K., and D. Papahadjopoulos. 1975. Phase transitions and separations in phospholipid membranes induced by changes in temperature, pH, and concentration of bivalent cations. Biochemistry. 14:152-161.
28. Jan, H., T. Lookman, and D. A. Pink. 1984. On computer simulation methods used to study models of two-component lipid bilayers. Biochemistry. 23:3227-3231.
29. Janiak, M. J., D. M. Small, and G. G. Shipley. 1976. Nature of the thermal pretransition of synthetic phospholipids: dimyristoyl-and dipalmitoyl-lecithin. Biochemistry. 15:4575-4580.
30. Janiak, M. J., D. M. Small, and G. G. Shipley. 1979. Temperature and compositional dependence of the structure of hydrated dimyristoyl lecithin. J. Biol. Chem. 254:6068-6078.
31. Johann, C., P. Garidel, L. Mennicke, and A. Blume. 1996. New approaches for the simulation of heat capacity curves and phase diagrams of pseudobinary phospholipid mixtures. Biophys. J. 71:3215-3228.
32. Kawasaki, K. 1972. Kinetics of Ising models. In Phase Transitions and Critical Phenomena. C. Domb and M. S. Green, editors. Academic Press, London. 443-501.
33. Lee, A. G. 1975a. Functional properties of biological membranes: a physical-chemical approach. Prog. Biophys. Mol. Biol. 29:3-56.
34. Lee, A. G. 1975b. Fluorescence studies of chlorophyll a incorporated into lipid mixtures, and the interpretation of "phase" diagrams. Biochim. Biophys. Acta. 413:11-23.
35. Lee, A. G. 1977a. Lipid phase transitions and phase diagrams. I. Lipid phase transitions. Biochim. Biophys. Acta. 472:237-281.
36. Lee, A. G. 1977b. Lipid phase transitions and phase diagrams. II. Mixtures involving lipids. Biochim. Biophys. Acta. 472:285-344.
37. Lee, A. G. 1978. Calculation of phase diagrams for non-ideal mixtures of lipids, and a possible random distribution of lipids in lipid mixtures in the liquid cristalline phase. Biochim. Biophys. Acta. 507:433-444.
38. Lee, A. G., N. J. M. Birdsall, J. C. Metcalfe, P. A. Toon, and G. B. Warren. 1974. Cluster in lipid bilayers and the interpretation of thermal effects in biological membranes. Biochemistry. 13:3699-3705.
39. Lewis, R. N. A. H., N. Mak, and R. N. Mc. Elhaney. 1987. A differential scanning calorimetric study of the thermotropic phase behavior of model membranes composed of phosphatidylcholines containing linear saturated fatty acyl chains. Biochemistry. 26:6118-6126.
40. Luna, E. J., and H. M. McConnell. 1977. Lateral phase separations in binary mixtures of phospholipids having different charges and different crystalline structures. Biochim. Biophys. Acta. 470:303-316.
41. Mabrey, S., and J. M. Sturtevant. 1976. Investigation of phase transition of lipids and lipid mixtures by high sensitivity differential scanning calorimetry. Proc. Natl. Acad. Sci. USA. 73:3862-3866.
42. Mason, J. T. 1988. Mixing behavior of symmetric chain length and mixed chain length phosphatidylcholines in two-component multilamellar bilayers: evidence for gel and liquid-crystalline phase immiscibility. Biochemistry. 27:4421-4429.
43. McIntosh, T. J. 1980. Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. Biophys. J. 29:237-246.
44. McLaughlin, S., and J. Brown. 1981. Diffusion of calcium ions in retinal rods. A theoretical calculation. J. Gen. Physiol. 77:475-487.
45. Mennicke, L. 1995. Die Simulation der Wärmekapazitätskurven und die Berechnung der Phasendiagramme von pseudobinären Lipid-Lipid-Wasser Systemen am Beispiel von gemischtkettigen Phospholipiden mit verzweigten Acylketten. Ph.D. thesis. University of Kaiserslautern, Kaiserslautern, Germany.
46. Metcalf, T. N., J. L. Wang, and M. Schindler. 1986. Lateral diffusion of phospholipids in the plasma membrane of soyabean protoplasts: evidence for membrane lipid domains. Proc. Natl. Acad. Sci. USA. 83: 95-99.
47. Nibu, Y., T. Inoue, and I. Motoda. 1995. Effect of headgroup type on the miscibility of homologous phospholipids with different acyl chain lengths in hydrated bilayer. Biophys. Chem. 56:273-280.
48. Shimshick, E. J., and H. M. McConnell. 1973. Lateral phase separation in phospholipid membranes. Biochemistry. 12:2351-2360.
49. Silvius, J. R. 1986. Solid-and liquid-phase equilibria in phosphatidylcholine/phosphatidylethanolamine mixtures. A calorimetric study. Biochim. Biophys. Acta. 857:217-228.
50. Silvius, J. R., and J. Gagné. 1984a. Lipid phase behavior and calcium induced fusion of phosphatidylethanolamine-phosphatidylserine vesicles. Calorimetric and fusion studies. Biochemistry. 23:3232-4340.
51. Silvius, J. R., and J. Gagné. 1984b. Calcium-induced fusion and lateral phase separation in phosphatidylcholine-phosphatidylserine vesicles. Correlation by calorimetric and fusion measurements. Biochemistry. 23:3241-4347.
52. Stier, A., and E. Sackmann. 1973. Spin labels as enzyme substrates. Heterogeneous lipid distribution in liver microsomal membranes. Biochim. Biophys. Acta. 311:400-408.
53. Sugár, I. P. 1987. Cooperativity and classification of phase transitions. Application to one-and two-component phospholipid membranes. J. Phys. Chem. 91:95-101.
54. Tardieu, A., V. Luzzati, and F. C. Reman. 1973. Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases. J. Mol. Biol. 75:711-733.
55. Tenchov, B. 1985. Nonuniform lipid distribution in membranes. Prog. Surf. Sci. 20:273-340.
56. Tocanne, J.-F., L. Cézanne, A. Lopez, B. Piknova, V. Schram, J.-F. Tournier, and M. Welby. 1994. Lipid domains and lipid/protein interactions in biological membranes. Chem. Phys. Lipids. 73:139-158.
57. Tokutomi, S., K. Ohki, and S.-I. Ohnishi. 1980. Proton-induced phase separation in phosphatidylserine/phosphatidylcholine membranes. Biochim. Biophys. Acta. 596:192-200.
58. Träuble, H. 1976. Membrane electrostatics. In Structure of Biological Membranes. S. Abrahamsson and I. Pascher, editors. Plenum Press, New York. 509-550.
59. Träuble, H., and H. J. Eibl. 1974. Electrostatic effects on lipid phase transitions: membrane structure and ionic environment. Proc. Natl. Acad. Sci. USA. 71:214-219.
60. Träuble, H., M. Teubner, P. Woolley, and H. Eibl. 1976. Electrostatic interactions at charged lipid membranes. I. Effects of pH and univalent cations on membrane structure. Biophys. Chem. 4:319-342.
61. Tuchtenhagen, J. 1994. Kalorimetrische und FT-IR-spektroskopische Untersuchungen an Phospholipidmodellmembranen. Ph.D. thesis. University of Kaiserslautern, Kaiserslautern, Germany.
62. van Dijck, P. W. M., A. J. Kaper, H. A. J. Oonk, and J. De Gier. 1977. Miscibility properties of binary phosphatidylcholine mixtures. A calorimetric study. Biochim. Biophys. Acta. 470:58-69.
63. Vaz, W. L. C. 1994. Diffusion and reaction in phase-separated membranes. Biophys. Chem. 50:139-145.
64. Verkleij, A. J. 1984, Lipid intramembrane particles. Biochim. Biophys. Acta. 779:43-63.
65. 2+, and protein on the thermotropic behaviour of the negatively charged phospholipid, phosphatidylglycerol. Biochim. Biophys. Acta. 39:432-437.
66. Vaz, W. L. C. 1995. Percolation properties of two-component, two-phase phospholipid bilayers. Mol. Membr. Biol. 12:39-43.
67. von Dreele, P H. 1978. Estimation of lateral species separation from phase transitions in non-ideal two-dimensional lipid mixtures. Biochemistry. 17:3939-3943.
68. Wilkinson, D. A., and T. J. McIntosh. 1986. A subtransition in a phospholipid with a net charge, dipalmitoylphosphatidylglycerol. Biochemistry. 25:295-298.
69. Wu, S. H., and H. M. McConnell. 1975. Phase separation in phospholipid membranes. Biochemistry. 14:847-854.
70. Xu, H., F. A. Stephenson, and C.-H. Huang. 1987. Binary mixtures of asymmetric phosphatidylcholines with one acyl chain twice as long as the other. Biochemistry. 26:5448-5453.