Replacement of the 1′,4′-Phenylene Region in 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF) by 4,5,6,7-Tetrahydrobenzo[c]thiophene and 4,5,6,7-Tetrahydroisobenzofuran Nuclei

Journal of Organic Chemistry

Volumn 62, Issue 6, 1997, Pages 1599-1603

  Taylor, Edward C ^a   Dowling, James E ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FOLIC ACID ANTAGONIST; FOLYLPOLYGLUTAMATE SYNTHASE; N [3 [2 (2 AMINO 4 OXO 3,4,5,6,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDIN 6 YL)ETHYL] 4,5,6,7 TETRAHYDROBENZO[A]THIENOYL]GLUTAMIC ACID; N [3 [2 (2 AMINO 4 OXO 3,4,5,6,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDIN 6 YL)ETHYL] 4,5,6,7 TETRAHYDROISOBENZOFUROYL]GLYTAMIC ACID; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0030891817     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9619903     Document Type: Article

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