Effects of in vivo administration of G-CSF on neutrophil functions in healthy volunteers

European Journal of Haematology

Volumn 58, Issue 3, 1997, Pages 195-202

  Hoglund M ^a   Hakansson L ^a   Venge, P ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adhesion molecules; Chemotaxis; G CSF; Neutrophil function; Phagocytosis; Respiratory burst

Indexed keywords

FC RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; ARTICLE; CELL FUNCTION; CELL MIGRATION; CHEMOLUMINESCENCE; CHEMOTAXIS; CLINICAL TRIAL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NEUTROPHIL; NORMAL HUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030891664     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1997.tb00947.x     Document Type: Article

References (41)

1. DEMETRI GD, GRIFFIN JD. Granulocyte colony-stimulating factor and its receptor. Blood 1991: 78: 2791.
2. Yuo A, KITIGAWA S, OSAKA A. Recombinant human granulocyte colony stimulating factor as an activator of human granulocytes: potentiation of responses triggered by receptor-mediated agonists and stimulation of C3bi receptor expression and adherence. Blood 1989: 74: 2114.
3. FOSSAT C, STOPPA A-M, SAINTY D, et al. In vivo stimulation of neutrophil function by lenograstim (glycosylated rHuG-CSF) in oncohematologic patients: results of a Phase I trial. Stem Cells 1994: 12: 322.
4. XU S, HÖGLUND M, VENGE P. The effects of granulocyte colony-stimulating factor (G-CSF) on the degranulation of secondary granule proteins from human neutrophils in vivo may be indirect. Br J Haematol 1996: 93: 558.
5. OHSAKA A, KITAGAWA S, SAKAMOTO S, et al. In vivo activation of human neutrophil functions by administration of recombinant human granulocyte colony-stimulating factor in patients with malignant lymphoma. Blood 1989; 74: 2743.
6. YONG K, LINCH D. Differential effects of granulocyte- and granulocyte-macrophage colony-stimulating factors (G-and GM-CSF) on neutrophil adhesion in vitro and in vivo. Eur J Haematol 1992: 49: 251.
7. DE HAAS M, KERST M, VAN DER SCHOOT E, et al. Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effects on circulating neutrophils. Blood 1994: 84: 3885.
8. REPP R, VALERIUS T, SENDLER A, et al. Neutrophils express the high affinity receptor for IgG (FcγR1, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor. Blood 1991: 78: 885.
9. GABRILOVE J, JAKUBOWSKI A, FAIN K, et al. Phase I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma or the urothelium. J Clin Invest 1988: 82: 1454.
10. WELTE K, BONILLA MA, GILLIO AP, et al. Recombinant granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates. J Exp Med 1987: 165: 941.
11. ELSNER J, ROESLER J, EMMENDÖRFFER A, ZEIDLER C, LOHMANN-MATTHES M-L, WELTE K. Altered function and surface marker expression of neutrophils induced by rhG-CSF treatment in severe congenital neutropenia. Eur J Haematol 1992: 48: 10.
12. SPIEKERMANN K, EMMENDOERFFER A, ELSNER J, et al. Altered surface marker expression and function of G-CSF-induced neutrophils from test subjects and patients under chemotherapy. Br J Haematol 1994: 87: 31.
13. YUO A, KITAGAWA S, OKABE T, et al. Recombinant human granulocyte colony-stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenous leukemia. Blood 1987: 70: 404.
14. LINDEMANN A, HERRMAN F, OSTER W. Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy. Blood 1989: 74: 2644.
15. MARCOLONGO R, ZAMBELLO R, TRENTIN L, CASSATELLA M, GASPAROTTO G, AGOSTINO C. Childhood onset cyclic neutropenia: G-CSF therapy restores neutrophil count but does not influence superoxide anion and cytokine release by neutrophils. British Journal Haematology 1994: 89: 277.
16. ELSNER J, KAEVER V, EMMENDOERFER A, BREIDENBACH T, LOHMANN-MATTHES M-L, ROESLER J. Abnormal regulation in the signal transduction in neutrophils from patients with severe congenital neutropenia relation of impaired mobilisation of cytosolic free calcium to altered chemotaxis. superoxide anion generation and F-actin content. Exp Hematol 1993: 21: 38.
17. BENSINGER WI, PRICE TH, DALE DC, et al. The effects of daily recombinant human granulocyte colony-stimulating factor administration on normal granulocyte donors undergoing leukapheresis. Blood 1993: 81: 1883.
18. CASPAR C, SEGER R, BURGER J, GMUDR J. Effective stimulation of donors for granulocyte transfusions with recombinant methionyl granulocyte colony-stimulating factor. Blood 1993: 81: 2866.
19. SMITH WS, SUMNICHT GE, SHARPE RW, SAMUELSON D, MILLARD FE. Granulocyte colony-stimulating factor versus placebo in addition to penicillin G in randomized blinded study of Gram-negative penumonia sepsis: analysis of survival and multisystem organ failure. Blood 1995: 86: 1301.
20. PETTENGELL R, GURNEY G, RADFORD J. Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkins lymphoma: a randomised controlled trial. Blood 1992: 80: 1430.
21. GISSELBRECHT C, PRENTICE HG, BACIGALUPO A, et al. Placebo-controlled phase III trial of lenograstim in bone-marrow transplantation. Lancet 1994: 343: 696.
22. HÖGLUND M, SMEDMYR B, SIMONSSON B, TÖTTERMAN TH, BENGISSON M. Dose dependent mobilization of haematopoietic progenitor cells in healthy volunteers receiving glycosylated rHuG-CSF. Bone Marrow Trans 1996: 18: 19.
23. HÅKANSSON L, HÄLLGREN R, VENGE P. Regulation of granulocyte function by hyalorunic acid. In vitro and in vivo effects on phagocytosis, locomotion and metabolism. J Clin Invest 1980: 66: 298.
24. VADAS M, DAVID J, BUTTERWORTH A, PISANI N, SIONGOK T. A new method for the purification of human eosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of schistosoma mansoni. J Immunol 1979: 122: 1228.
25. HÅKANSSON L, SOEGGAARD NIELSEN L, TEDER P. Measurement of neutrophil and eosinophil adhesion to E-selectin, VCAM-1 and ICAM-1 by the use of transfected fibroblast cell lines. J Immunol Methods 1994: 176: 53.
26. VENGE P, ARTURSSON G. Locomotion of neutrophil granulocytes from patients with thermal injury. Identification of serum-derived inhibitors. Burns 1981: 6.
27. HÅKANSSSON L, VENGE P. The chemotactic activity of normal and complement-activated serum as measured by the leading-front method using a boyden chamber. Scand J Immunol 1984: 19: 63.
28. TRULSON A, NILSSON S, VENGE P. Lucigenin-enhanced chemiluminescence in blood is increased in cancer. Am J Clin Pathol 1989: 91: 441.
29. MACGREGOR RR, SPAGNULO P, LENTNER A. Inhibition of granulocyte adherence by ethanol, prednisone and aspirin measured with an assay system. N Engl J Med 1974: 291: 642.
30. HÅLLGREN R, JANSSON L, VENGE P. Kinetic studies of phagocytosis of IgG coated latex particles using a thrombocyte counter. J Lab Clin Med 1977: 90: 786.
31. HÅKANSSON L, HÄLLGREN R, VENGE P. Effect of hyaluronic acid on phagocytosis of latex particles. Scand J Immunol 1980: 11: 649.
32. HÅKANSSON L, VENGE P. Partial characterization and identification of chemokinetic factors in serum. Scand J Immunol 1983: 18: 531.
33. SMITH W, GAMBLE J, VADAS M. The role of granulocyte-macrophage and granulocyte colony-stimulating factors in neutrophil transendothelial migration: comparison with interleukin-8. Exp Hematol 1994: 22: 329.
34. ROESLER J, EMMENDÖRFER A, ELSNER J, ZEIDLER C, LOHMANN-MATTHES M. In vitro function of neutrophils induced by treatment with rhG-CSF in severe congential neutropenia. Eur J Haematol 1991: 46: 112.
35. MILLS E, RHOOL K, QUIE P. Luminol-amplified chemiluminescence: a sensitive method for detecting the carrier state in chronic granulomatous disease. J Clin Microbiol 1980: 12: 52.
36. WILLIAMS A, COLE P. The onset of polymorphonuclear leukocyte membrane-stimulated metabolic activity. Immunology 1981: 43: 733.
37. MACGREGOR R, MACARAK E, KEFALIDES N. Comparative adherence of granulocytes to endothelial monolayers and nylon fiber. J Clin Invest 1978: 61: 697.
38. BEVILACQUA M. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 1993: 11: 767.
39. KERST M, DE HAAS M, VAN DER SCHOOT E, et al. Recombinant granulocyte colony-stimulating factor administration to healthy volunteers: induction of immunophenotypically and functionally altered neutrophils via an effect on myeloid progenitor cells. Blood 1993: 82: 3265.
40. SIMMS H, FRANK M, QUINN T, HOLLAND S, GAITHER T. Studies on phagocytosis in patients with acute bacterial infections. J Clin Invest 1989: 83: 252.
41. BUCKLE A, HOGG, N. The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. J Immunol 1989: 143: 2295.