Suppressive effects of rebamipide, a novel anti-ulcer agent, on the number and function of granulocytes and extrathymic T cells in mice

Biomedical Research

Volumn 18, Issue 1, 1997, Pages 103-112

  Yamamura, Soichiro ^a   Toyabe, Shinichi ^a   Arai, Katsumitsu ^a   Kawamura, Toshihiko ^a   Hanyu, Tadamasa ^a   Takahashi, Hideaki E ^a   Abo, Toru ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIULCER AGENT; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; REBAMIPIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CONTROLLED STUDY; GRANULOCYTE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; T LYMPHOCYTE;

EID: 0030891639     PISSN: 03886107     EISSN: None     Source Type: Journal    
DOI: 10.2220/biomedres.18.103     Document Type: Article

References (34)

1. ABRAMSON S. B. and WISSMANN G. (1989) The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum. 32, 1-9
2. ARAKAWA T., NAKAMURA A., FUKUDA T., SATOH H. and KOBAYASHI K. (1988) Protection of isolated rat gastric cells by prostaglandins from damage caused by ethanol. J. Clin. Gastroenterol. 10, Suppl. 1, 528-534
3. ASAKO H., KUBES P., WALLACE J., GAGINELLA T., WOLF R. E. and GRANGER D. N. (1992) Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products. Amer. J. Physiol. 262, G903-908
4. BLASER M. J. (1990) Helicobactor pylori and the pathogenesis of gastroduodenal inflammation. J. Infect. Dis. 161, 626-633
5. DAMMANN H. G. (1994) Effects of rebamipide on aspirin-induced gastric damage: a case-control study. Eur. J. Gastroenterol. Hepatol. 6, 911-915
6. FUKUDA M., MORODA T., TOYABE S., IIAI T., KAWACHI Y., TAKAHASHI-IWANAGA H., IWANAGA T., OKADA M. and ABO T. (1996) Granulocytes induced by increasing sympathetic nerve activity contributes to the incidence of acute appendicitis. Biomedical Res. 17, 171-181
7. GOOSSENS P. L., JOUIN H., MARCHAL G. and MILON G. (1990) Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver. J. Immunol. Methods 132, 137-144
8. HAN B.-G., KIM H.-S., RHEE K.-H., HAN H.-S. and CHUNG M.-H. (1995) Effects of rebamipide on gastric cell damage by Helicobactor pylori-stimulated human neutrophils. Pharmacol Res. 32, 201-205
9. IIAI T., WATANABE H., SEKI S., SUGIURA K., HIROKAWA K., UTSUYAMA M., TAKAHASHI-IWANAGA H., IWANAGA T., OHTEKI T. and ABO T. (1992) Ontogeny and development of extrathymic T cells in mouse liver. Immunology 77, 556-563
10. KAWACHI Y., ARAI K., MORODA T., KAWAMURA T., UMEZU H., NAITO M., OHTSUKA K., HASEGAWA K., TAKAHASHI-IWANAGA H., IWANAGA T., SHULTS L. D., WATANABE H. and ABO T. (1995) Supportive cellular elements for hepatic T cell differentiation: T cells expressing intermediate levels of the T cell receptor are cytotoxic against syngeneic hepatoma, and are lost after hepatocyte damage. Eur. J. Immunol 25, 3452-3459
11. + intermediate TCR cells in the liver and other immune organs. Eur. J. Immunol. 25, 2272-2278
12. LEE S.-M. and KIM K. H. (1995) Rebamipide ameliorates hepatic dysfunction induced by ischemia-reperfusion in rats. Eur. J. Pharmacol. 294, 41-46
13. MARSHALL B. J., GOODWIN C. S., WARREN J. R., MURRAY R., BLINCOW E. D., BLACKBOURN S. J., PHILLIPS M., WATERS T. E. and SANDERSON C. R. (1988) Prospective double-blind trial of duodenal ulcer relapse after eradication of campylobacter pylori. Lancet 2, 1437-1442
14. NAITO Y., YOSHIKAWA T., MATSUYAMA K., YAGI N., MAKAMURA Y., NISHIMURA S. and KONDO M. (1994) Effects of rebamipide, a novel anti-ulcer agent, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Pathophysiology 1, 161-164
15. NAITO Y., YOSHIKAWA T., TANIGAWA T., SAKURAI K., YAMASAKI K., UCHIDA M. and KONDO M. (1995) Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study. Free Radical Biol. Med. 18, 117-123
16. PSHENNIKOVA M. G., KUZNETSOVA B. A., SHIMKOVICH M. V., SAPRYGIN D. B. and MEERSON F. Z. (1990) Relations of catecholamine and prostaglandin contents in the blood of rats exposed to acute stress and during adaptation to stress. Biul. Eksp. Biol. Med. 109, 534-535
17. PSHENNIKOVA M. G., KUZNETSOVA V. A., KOPYLOV I., SHIMKOVICH M. V., VOVK V. I., SAPRYGIN D. V., MEERSON F. Z. and KARDIOLOGIIA S. O. (1992) The role of the prostaglandin system in the cardioprotective effect of adaptation to hypoxia in stress. Kardioligiia 32, 61-64
18. RIGG K. M., SHENTON B. K., MURRAY I. A., GIVAN A. L., TAYLOR R. M. R. and LENNARD T. W. J. (1989) A flow cytometric technique for simultaneous analysis of human mononuclear cell surface antigens and DNA. J. Immunol. Methods 123, 177-184
19. SATO K., OHTSUKA K., HASEGAWA K., YAMAGIWA S., WATANABE H., IWANAGA T., TAKAHASHI-IWANAGA H., ASAKURA H. and ABO T. (1995) Evidence for extrathymic generation of intermediate TCR cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J. Exp. Med. 182, 759-767
20. STOREK J., SCHMID I., FERRARA S. and SAXON A. (1992) A novel B cell stimulation/proliferation assay using simultaneous flow cytometric detection of cell surface markers and DNA content. J. Immunol. Methods 151, 261-267
21. SUNG J. J. Y., CHUNG S. C. S., LING T. K. W., YUNG M. Y., LEUNG V. K. S., NG E. K. W., LI M. K. K., CHENG A. F. B. and LI A. K. C. (1995) Antibacterial treatment of gastric ulcers associated with Helicobactor pylori. N. Engl. J. Med. 332, 139-142
22. SUZUKI M., ASAKO H., KUBES P., JENNINGS S., GRISHAM M. B. and GRANGER D. N. (1991) Neutrophil-derived oxidants promote leukocyte adherence in postcapillary venules. Microvascul. Res. 42, 125-138
23. SUZUKI M., MIURA S., MORI M., KAI A., SUZUKI H., FUKUMURA D., SUEMATSU M. and TSUCHIDA M. (1994) Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. Gut 35, 1375-1378
24. TAKEDA Y., WATANABE H., YONEHARA S., YAMASHITA T., SAITO S. and SENDO F. (1993) Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α. Int. Immunol. 5, 691-694
25. VANE J. R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature 231, 232-235
26. + T cells are present within a population of intermediate TCR cells. J. Immunol. 155, 2972-2983
27. WATANABE H., OHTSUKA K., KIMURA M., IKARASHI Y., OHMORI K., KUSUMI A., OHTEKI T., SEKI S. and ABO T. (1992) Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods 146, 145-154
28. XIONG H., KAWAMURA I., NISHIBORI T. and MITUSYAMA M. (1994) Cytokine gene expression in mice at an early stage of infection with various strains of Listeria spp. differing in virulence. Infect. Immun. 62, 3649-3654
29. int cells in SCG and MRL-lpr/lpr mice which produce normal Fas mRNA and Fas molecules from the lpr gene. Eur. J. Immunol. 26, 1409-1416
30. YAMAMURA S., ARAI K., TOYABE S., TAKAHASHI H. E. and ABO T. (1996) Simultaneous activation of granulocytes and extrathymic T cells in number and function by excessive administration of non-steroidal anti-inflammatory drugs (NSAIDs). Cell Immunol. 173, 303-311
31. YAMASAKI K. and SAKURAI K. (1994) Role of lipid peroxidation in protection of rats by rebamipìde against gastric mucosal lesions induced by stress plus indomethacin, Pathophysiology 1, 251-257
32. YANG J., KAWAMURA I., ZHU H. and MITSUYAMA M. (1995) Involvement of natural killer cells in nitric oxide production by spleen cells after stimulation with Mycobacterium bovis BCG. J. Immunol. 155, 5728-5735
33. YOSHIDA M., KITAHORA T., WAKABAYASHI G., TASHIRO H., ONO H., OTANI Y., SHIMAZU M., KUBOTA T., KUMAI K. and KITAJIMA M. (1995) Active oxygen species in formation of acute gastric mucosal lesions induced by thermal injury in rats. Dig. Dis. Sci. 40, 1306-1310
34. 2+-mobilizing agonists. J. Immunol. 142, 1678-1684