Autoantibody selectively inhibits binding of von Willebrand factor to glycoprotein Ib. Recognition site is located in the A1 loop of von Willebrand factor

Thrombosis and Haemostasis

Volumn 77, Issue 4, 1997, Pages 760-766

  Mohri, Hiroshi ^a   Yamazaki, Etsuko ^a   Suzuki, Zekou ^b   Takano, Toshikuni ^b   Yokota, Shumpei ^a   Okubo, Takao ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BLOOD CLOTTING FACTOR 8; BOTROCETIN; GLYCOPROTEIN IB; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT PROTEIN; RISTOCETIN; SYNTHETIC PEPTIDE; VON WILLEBRAND FACTOR;

ADULT; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BLEEDING TENDENCY; BRAIN HEMORRHAGE; CASE REPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; VON WILLEBRAND DISEASE;

EID: 0030891054     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1656047     Document Type: Article

References (35)

1. Ruggeri ZM, Ware J. The structure and function of von Willebrand factor. Thromb Haemost 1992; 67: 594-602.
2. Ikeda Y, Handa M, Kawano K, Kamata T, Murata M, Araki Y, Ando H, Kawai Y, Watanabe K, Itagaki I, Sakai K, Ruggeri ZM. The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 1991; 87: 1234-40.
3. Ruggeri ZM, De Marco L, Gatti L, Bader R, Montgomery RR. Platelet have more than one binding site for von Willebrand factor. J Clin Invest 1983; 72: 1-12.
4. Mohri H, Yoshioka A, Zimmerman TS, Ruggeri ZM. Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites. J Biol Chem 1989; 264: 17361-7.
5. Kao K-J, Pizzo SV, McKee PA. Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. J Clin Invest 1979; 63: 656-64.
6. Read MS, Shermer RW, Brinkhous KM. Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. Proc Natl Acad Sci USA 1978; 75:4514-21.
7. Sadler JE. A revised classification of von Willebrand disease. Thromb Haemost 1994; 71: 520-5.
8. Lopez-Fernandez MF, Martin R, Lopez-Berges C, Ramos F, Bosch N, Batlle J. Further specificity characterization of von Willebrand factor inhibitors developed in two patients with severe von Willebrand disease. Blood 1988; 72: 116-20.
9. Ruggeri ZM, Ciavarella N, Mannucci PM, Molinari A, Dammacco F, Lavergne JM, Meyer D. Familial incidence of precipitating antibodies in von Willebrand's disease. A study of four cases. J Lab Clin Med 1979; 94: 60-9.
10. Mannucci PM, Ruggeri ZM, Ciavarella N, Kazatchkine MD, Mowbray JF. Precipitating antibodies to factor VIII/von Willebrand factor in von Willebrand's disease: Effects on replacement therapy. Blood 1981; 57: 25-32.
11. Van Genderen PJJ, Vink T, Michiels JJ, van't Veer MB, Sixma JJ, van Vliet HDM. Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen. Blood 1994; 84: 3378-83.
12. Girma JP, Chopeck M, Titani K, Davie E. Limited proteolysis of human von Willebrand factor by Staphylococcus aureus V-8 protease: Isolation and partial characterization of a platelet-binding domain. Biochemistry 1986; 25: 3156-63.
13. Fujimura Y, Titani K, Holland LZ, Russell SR, Roberts JR, Elder JH, Ruggeri ZM, Zimmerman TS. von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib. J Biol Chem 1986; 261: 381-5.
14. Andrew RK, German JJ, Booth WJ, Castaldi PA, Berndt MC: Cross-linking of a monomeric 39/34 kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the α-chain of membrane glycoprotein Ib on intact platelets with Bis (sulfosuccimidyl) suberate. Biochemistry 1989; 28: 8317-26.
15. Mohri H, Fujimura Y, Shima M, Yoshioka A, Houghten RA, Ruggeri ZM, Zimmerman TS. Structure of the von Willebrand factor domain interacting with glycoprotein Ib. J Biol Chem 1988; 263: 17901-4.
16. Berndt MC, Ward CM, Booth WJ, Castaldi PA, Mazurov AV, Andrews R. Identification of aspartic acid-514 through glutamic acid-542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin. Biochemistry 1992; 31: 11144-51.
17. Girma J-P, Ribba A-S, Meyer. Structure-function relationship of the A1 domain of von Willebrand factor. Thromb Haemost 1995; 74: 156-60.
18. Duke WW. The reaction of blood platelets to hemorrhagic disease: Description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. J Am Med assoc 1910; 55: 1185-91.
19. Macfarlane DE, Stibbe J, Kirby EP, Zucker MB, Grant RA, McPherson JA. A method for assaying von Willebrand factor (Ristocetin cofactor). Thromb Diath Haemorrh 1975; 43: 303-6.
20. Marti T, Roesselet S, Titani K, Walsh KA. Identification of disulfide-bridged substructures within human von Willebrand factor. Biochemistry 1987; 26: 8099-109.
21. Miura S, Nishida S, Makita K, Sakurai Y, Shimoyama T, Sugimoto M, Yoshioka A, Ishii K, Kito M, Kobayashi T, Fujimura Y. Inhibition assay for the binding of biotinylated von Willebrand factor to platelet-bound microtiter wells in the presence of ristocetin or botrocetin. Analy Biochem 1996; 236: 215-20.
22. De Marco L, Girolami A, Russell S, Ruggeri ZM. Properties of human asialo-factor VIII: A ristocetin-independent platelet-aggregating agent. J Clin Invest 1985; 75: 1198-203.
23. De Marco L, Shapiro SS. Properties of human asialo-factor VIII. A ristocetin-independent platelet aggregating agent. J Clin Invest 1981; 68: 321-8.
24. Fracker DJ, Speck JC. Protein and cell membrane iodinations with a sparingly soluble chloramide 1, 3, 4, 6 tetrachloro 3a, 6a diphenyl-glycoluril. Biochem Biophys Res Commun 1978; 80: 849-57.
25. Ey PL, Prowse SJ, Jenkin CR. Isolation of pure IgG1, IgG2a, and IgG2b immunoglobulins from mouse serum using protein A-sepharose. Immunochemistry 1978; 15: 429-36.
26. Parham P. On the fragmentation of monoclonal IgG1, IgG2a, and IgG2b from BALB/c mice. J Immunol 1983; 131: 2895-902.
27. Handa M, Titani K, Holland LZ, Roberts JR, Ruggeri ZM. The von Wille-brand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments. J Biol Chem 1986; 261: 12579-85.
28. Brosstad F, Kjonniksen I, Ronning B, Stormorken H. Visualization of von Willebrand factor multimers by enzyme-conjugated secondary antibodies. Thromb Haemost 1986; 55: 276-81.
29. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analy Biochem 1976; 72: 248-54.
30. Sugimoto M, Ricca G, Hrinda ME, Schreiber AB, Searfoss GH, Bottini E, Ruggeri ZM. Functional modulation of the isolated glycoprotein-Ib binding domain of von Willebrand factor expressed in Escherichia coli. Biochemistry 1991; 30: 5202-9.
31. Mohri H, Tanabe J, Ohtsuka M, Yoshida M, Motomura S, Nishida S, Fujimura Y, Okubo T. Acquired von Willebrand disease associated with multiple myeloma; characterization of an inhibitor to von Willebrand factor. Blood Coagul Fibrinolys 1995; 6: 561-6.
32. Mohri H, Tanabe J, Yamazaki E, Yoshida M, Harano H, Matsuzaki M, Motomura S, Okubo T. Acquired type 2A von Willebrand disease in chronic myelocytic leukemia. Hematopathol Mol Hematol 1996; 10: 123-33.
33. Cruz MA, Handin RI, Wise RJ. The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein-Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem 1993; 268: 21238-45.
34. Gralnick HR, Williams S, McKeown L, Kramer W, Krutzsch H, Gorecki M, Pinet A, Garfinkel LI. Monomeric von Willebrand factor fragment, Leu-504-Ser-728, inhibits von Willebrand factor interaction with glycoprotein Ib/IX. Proc Natl Acad Sci USA 1992; 89: 7880-4.
35. 728. Blood 1987; 70: 985-8.