Cytotoxic effect of sodium nitroprusside on cancer cells: Involvement of apoptosis and suppression of C-MYC and C-MYB proto-oncogene expression

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 865-871

  Sumitani, Kaname ^a   Kamijo, Ryutaro ^a   Nagumo, Masao ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cancer cells; Cytotoxicity; Proto oncogene; Sodium nitroprusside

Indexed keywords

DNA FRAGMENT; MESSENGER RNA; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

APOPTOSIS; ARTICLE; CANCER CELL; CELL KILLING; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE REPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; NORTHERN BLOTTING; NUCLEOSOME; ONCOGENE C MYB; ONCOGENE C MYC; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA FRAGMENTATION; DOWN-REGULATION; GENES, MYC; HUMANS; NITRIC OXIDE; NITROPRUSSIDE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB; PROTO-ONCOGENES; RNA, MESSENGER; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0030891046     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Decker T Lohmann-Matthes MC and Gifford G: Cell associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages. J Immunol 138: 957-960, 1987.
2. Kamijo R, Shapiro D, Le J, Huang S, Aguet M and Vilcek J: Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the Interferon y receptor. Proc. Natl Acad Sci USA 90: 6626-6630, 1993.
3. Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, Le J, Koh SI, Kimura T, Green SJ, Mak TW, Taniguchi T and Vilcek J: Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263: 1612-1615, 1994.
4. Nathan CF and Hibbs, JBJr: Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3: 65-70, 1991.
5. Liew FY and Cox FEG: Nonspecific defence mechanism: the rule of nitric oxide. Immunol Today 12: A17-A21, 1991.
6. Keller, R, Geiges, M and Keist R: L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages. Cancer Res 50: 1421-1425, 1990.
7. Xie K, Huang S, Dong Z and Fidler IJ: Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric oxide. Int J Oncol 3: 1043-1047, 1993.
8. Hibbs JBJr, Vavrin Z and Taintor RR: L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 138: 550-565, 1987.
9. Palmer RMJ, Rees DD, Ashton DS and Moncada S: Vascular endotherial cells synthesize nitric oxide from L-arginine. Nature (Lond.) 333: 664-666, 1988.
10. Ignarro LJ, Buga GM, Wood KS, Byrns RE and Chaudfiuri G: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84: 9265-9269, 1990.
11. Radomski MW, Palmer, RMJ and Moncada S: An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87: 5193-5197, 1990.
12. Radomski MW, Palmer, RMJ and Moncada S: Characterization of the L-arginine: nitric oxide pathway in human platelets. Br J Pharmacol 101: 325-328, 1990.
13. Beckan JS: Peroxynitrite versus hydroxyl radical: the role of nitric oxide in superoxide-dependent cerebral injury. Ann N Y Acad Sci 738: 69-75, 1994.
14. Royrall JA, Kooy NW and Beckman JS: Nitric oxide-related oxidants in acute lung injury. New Horiz 3: 113-122, 1995.
15. Moncada S, Palmer, RMJ and Higgs EA: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142, 1991.
16. Hibbs JBJr. Taintor RR, Vavrin Z, Granger DL, Drapier J-C, Amber IJ and Lancaster JRJr: Synthesis of nitric oxide from a terminal guanidino nitrogen atom of L-arginine: a molecular mechanism regulating cellular proliferation that target intracellular iron. In: S. Moncada and E. A. Higgs (eds), Nitric oxide from L-arginine: a bioregulalory system. Amsterdam. Elsevier, 1990, pp.189-223.
17. Moncada S, Marletta MA, Hibbs JBand Higgs EA (eds): The biology of nitric oxide. Portland Press, Portland, 1991.
18. Hoffman B and Liebermann DA: Molecular controls of apoptosis: differentiation/growth arrest primary response genes, protooncogenes, and tumor suppressor genes as positive and negative modulators. Oncogene 9: 1807-1812, 1994.
19. Hori M, Kamijo R, Takeda K und Nagunio M: Downregulution of cmyc expression by tumor necrosis factor-ex in combination with transforming growth factor-ß or interteron-γ with concomitant inhibition of proliferation in human cell lines. J IFN Res 14: 49-55, 1994.
20. Evan G, Wyllie A, Gilbert C, Littlewood T, Land H, Brooks M, Waters C, PennL and Hancock D: Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992.
21. Kamijo R, Takeda K and Nagumo M and Konno K: Suppression of TNF-stimulated proliferation of diploid fibroblasts and TNF-induced cytoloxicity against transformed fibroblasts by TGF-ß. Biochem. Biophys. Res Commun 158: 155-162, 1989.
22. Hibbs JBJr, Taintor RR, Vavrin Z: Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science, 235: 473-476, 1987.
23. Hibbs JBJr, Taintor RR, Vavrin Z: and Rachlin, EM: Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157: 87-94, 1988.
24. Griffith TM, Edwards DH, Lewis MJ, Newby AC and Henderson AH: The nature of endothelium-delived vascular relaxant factor. Nature 308: 645-647, 1984.
25. Cocks TM, Angus JA, Campbell JH and Campbell GR: Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture. J Cell Physiol 123: 310-320, 1985.
26. Bates JN, Baker MT, Gucrra RJr and Harrison DG: Nitric oxide generation from nitroprusside by vascular tissue: evidence that reduction of the nitroprusside an anion and cyanide loss are required. Biochem Pharmacol 42 Suppl 157-165, 1991.
27. Katsuki S, Arnold WP, Mittal CK and Murad F: Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin, and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res 3: 23-35, 1977.
28. Ignarro LJ, Edwards JC, Gruetter DY, Barry BK and Gruetter, CA: Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds. FEES Lett 110: 275-278, 1980.
29. Freelisch M and Noack E: Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or nun-heme iron. Eur J Pharmacol 142: 405-469, 1987.
30. WyllieAH, Kerr JFR and Currie AR: Cell death: the significance of apoptosis. Int Rev Cytol 68: 251-306, 1980.
31. Evan GI, Littlewood TD: The role of c-myc in cell growth. Curr. Opin Genet Dev 3: 44-49, 1993.
32. White E: Death-defying acts: a meeting review of apoptosis. Genes Dev 7: 2277-2284, 1993.
33. Shi Y, Glynn J, Guilbeirt L, Cotter T, Bissonnette R and Green D: Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257: 212-214, 1992.
34. Askew DS, Ashmun RA, Simmons BC, Cleveland JL: Constitutive cmyc expression in an IL-3-dependcnt myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6: 1915-1922, 1991.
35. Klempnauer KH, Gonda TJ and Bishop JM: Nucleotide sequence of the retroviral leukemia gene v-myh and its cellular progenitor c-myb. the architecture of a transduced oncogene. Cell 31: 453-463, 1982.
36. Radke K., Beug H, Kornfeld Sund Graf T: Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell 31: 643-653, 1982.
37. Biedenkapp H, Borgenmeyer U, Sippel AE and Klempnauer KH, Viral myb oncologene encodes a sequence-specific DNA-binding activity. Nature 335: 835-837, 1988.
38. Ness SA, Marknell A and Graf T: The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene. Cell 59: 1115- 1125, 1989.
39. Weston K and Bishop JM: Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell 58: 85-93, 1989.
40. Zobel A, Kalkbrenner F, Guehmann S, Nawralh M, Vorbueggen G and Moelling K: Interaction of the v- and c-myb proteins with regulatory sequence of the human c-myc gene. Oncogene 6: 1397- 1407, 1991.
41. Nakagoshi, H, Kanei-Ishii, C, Sawazaki T, Mizuguchi G and Ishii S: Transeriptional activation of the c-myc gene by the c-myb and B-myb gene products. Oncogene 7: 1233-1240, 1992.