An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: Sodium-dependency and colocalization with paroxetine

British Journal of Pharmacology

Volumn 120, Issue 7, 1997, Pages 1255-1262

  Meoni, P ^a,c   Tortella, F C ^b   Bowery, N G ^c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

receptors; 5 HT uptake; Antitussives; Autoradiography; Dextromethorphan; Paroxetine

Indexed keywords

ANTITUSSIVE AGENT; DEXTROMETHORPHAN; LIGAND; PAROXETINE; PHENYTOIN; SEROTONIN; SODIUM; SODIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SEROTONIN UPTAKE;

ANIMALS; AUTORADIOGRAPHY; BINDING SITES; BRAIN; DEXTROMETHORPHAN; IONS; KINETICS; MALE; PAROXETINE; RATS; RATS, WISTAR; SEROTONIN; SODIUM; TRITIUM;

EID: 0030890833     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701043     Document Type: Article

References (32)

1. AHTEE, L. (1975). Dextromethorphan inhibits 5-hydroxytryptamine uptake by human blood platelets and decreases 5-hydroxyindoleacetic acid content in rat brain. J. Pharm. Pharmacol., 27, 107-180.
2. BENSON, W.M., STEFKO, P.L. & RANDALL, L.O. (1953). Comparative pharmacology of lervorphan, racemorphan and dextrorphan and related methyl ethters. J. Pharmacol. Exp. Ther., 109, 189-200.
3. BUUS-LASSEN, J. (1978). Potent and long-lasting potentiation of two 5-hydroxytriptophan-induced effects in mice by three selective 5HT uptake inhibitors. Eur. J. Pharmacol., 47, 351-358.
4. 3H]-dextromethorphan binding to different structures of the guinea-pig brain: autoradiouraphic evidence for multiple binding sites. Life Sci. PL9-PL16.
5. 3H]-paroxetine binding sites in rat brain. J. Pharmacol. Toxicol. Math., 4, 209-216.
6. CRAVISO, G.L. & MUSACCHIO, J.M. (1980). High affinity binding of the antitussive dextromethorphan to guinea-pig brain. Eur. J. Pharmacol., 65, 451-453.
7. CRAVISO, G. L. & MUSACCHIO, J.M. (1983a). High affinity dextromethorphan binding sites in guinea-pig brain. I. Initial characterization. Mol. Pharmacol., 23, 619-628.
8. CRAVISO, G.L. & MUSACCHIO, J.M. (1983b). High affinity dextromethorphan binding sites in guinea-pig brain. II. Competition experiments. Mol. Pharmacol., 23, 629-640.
9. EDDY, N.B., FRIRBEL, H., HAHN, K.J. & HALBACH, H. (1969). Codeine and its derivatives for pain and cough relief. 4. Potential alternatives for cough relief. Bull. WHO, 639-719.
10. FINNEGAN, K.T., KERR, J.T. & LANGSTON, J.W. (1991). Dextromethorphan protects against the neurotoxic effect of p-chloro amphetamine in rats. Brain Res., 558, 109-111.
11. 3H]-phenytoin identifies a novel anticonvulsant-binding domain on voltagedependent sodium channels. Mol. Pharmacol., 42, 1097-1103.
12. 3H]-paroxetine. In Neuronal Serotonin. ed. Osborne, N.N. & Hamon, H. p. 376, Chichester: John Wiley & Sons.
13. 3H]-paroxetine binding to rat cortical membranes. Eur. J. Pharmacol., 118, 107-114.
14. KAMEI, J., OGAWA, M. & KASUYA, Y. (1987). Monoamines and the mechanisms of action of antitussive drugs in rats. Arch. Int. Pharmacodyn. Ther., 290, 117-127.
15. KAMEI, J., OGAWA, M. & KASUYA, Y. (1988). Supersensitivity of 5.7-dihydroxytrytamine treated rats to the respiratory depressant and antitussive effects of dihydrocodeine. Eur. J. Pharmacol., 153, 305-308.
16. KAMEI, J., MORI, T., HIGARASHI, H. & KASUYA, Y. (1992). Serotonin release in the nucleus of te solitary tract and its modulation by antitussive drugs. Res. Comm. Pathol. Pharmacol., 76, 371-374.
17. 3H]-dextromethorphan and sigma ligands to guineapig brain. Life Sci., 48, 543-550.
18. KLEIN, M. & MUSACCHIO, L.M. (1990). Computer-assisted analysis of dextromethorphan and (+)PPP binding sites in the rat brain. Allosteric effects of ropizine. Life. Sci., 47, 1625-1634.
19. KLEIN, M. & MUSACCHIO, J.M. (1992). High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(l-propyl)piperidine binding sites in rat brain. Allosteric effect of ropizine. J. Pharmacol. Exp. Ther., 260, 990-999.
20. MUSACCHIO, J.M., KLEIN, M. & CANOLL, P.D. (1489). Dextromethorphan and sigma ligands: common sites hut diverse effects. Life Sci., 45, 1721-1732.
21. MUSACCHIO, J.M., KLEIN, M. & SANTIAGO, L.J. (1988). High affinity dextromethorphan binding sites in guinea-pig brain: further characterization and allosterical interactions. J. Pharmacol. Exp.Ther., 247, 424-431.
22. NEWMAN, A.H., BEVAN, K., BOWERY, N.G. & TORTELLA, K (1992). Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. J. Med. Chem., 35, 4135-4142.
23. NlERENBERG, D.W. & SEMPREBON, M. (1993). The central nervous serotonin syndrome. Clin. Pharmacol. Ther., 53, 84-88.
24. 3H]-GBR 12935 binding proteins. Arch. Biochem. Biophys., 276, 424-432.
25. SCHENKMAN, J.B., BEVERLEY, B.J. & CINTI, D.L. (1972). Diethylaminoethyl 2,2-diphenylvalerateHCI (SKF 525A) in vivo and in vitro effects of metabolism by rat liver microsomes formation of an oxygenated complex. Biochem. Pharmacol., 21, 2373-2383.
26. SCHMID, B., BIRCHER, R., PREISIG, R. & KUPFER, A. (1985). Polymorphic dextromethorphan metabolism: co-segregation of oxidativc o-demethylation with debrisoquine hydroxylation. Clin. Pharmacol. Ther., 38, 618-624.
27. SINCLAIR, J.G. (1973). Dextromethorphan-monoamine oxidase inhibitor interaction in rabbits. J. Pharm. Pharmacol., 25, 803-808.
28. SINCLAIR, J.B. & LO, G.F. (1976). The blockade of serotonin uptake into synaptosomes: relationship to an interaetion with monoamine oxidase inhibitors. Can. J. Physiol. Pharmacol., 55, 180-187.
29. SOVNER, R. & WOLFE, J. (1988). Interaction between dextromethorphan and monoamine oxidase inhibitor therapy with isocarboxazid [letter]. New Engl. J. Med., 319, 1671.
30. STEINBERG, G.K., ENG, H.L., KUNIS, D.M., GRANT, G.A., POLIJAK & DELAPAZR, (1991). Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia. Neurosci Lett., 133, 225-228.
31. TORTELLA, F.C. & MUSACCHIO, J.M. (1986). Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties. Brain Res., 383, 314-319.
32. ZHOU, G. & MUSACCHIO, J.M. (1991), Computer-assisted modelling of multiple dextromethorphan and sigma binding sites in guineapig brain. Eur. J. Pharmacol. Mol. Pharmacol. Sect., 206, 261-269.