Anticonvulsive activity of a new GABA mimetic drug

European Neuropsychopharmacology

Volumn 7, Issue 1, 1997, Pages 57-63

  Capasso, A ^a   Biondi, A ^b   Palagiano, F ^b   Bonina, F P ^c   Montenegro, L ^c   De Caprariis, P ^d   Pistorio, E ^b   Sorrentino, L ^b  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d UNIVERSITY OF SASSARI   (Italy)

Author keywords

anticonvulsant; systemic administration; aminobutyric acid (GABA)

Indexed keywords

4 AMINOBUTYRIC ACID; 4 [(2H) 1,3 BENZOXAZINE 2,4 (3H) DIONE]BUTYRIC ACID; ANTICONVULSIVE AGENT; BICUCULLINE; BUTYRIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; CATALEPSY; CONVULSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030890805     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(96)00390-2     Document Type: Article

References (29)

1. Amabeoku, G.J. and Chikuni, O. (1992) Effects of some GABAergic agents on quinine-induced seizures in mice. Experientia 48, 659-662.
2. Bakay, R.A.E. and Harris, A.B. (1981) Neurotransmitter receptor and biochemical changes in monkey cortical epileptic foci. Brain Res. 206, 387-404.
3. Bianchi, M., Deana, R., Quadro, G., Mourier, G. and Galzigna, L. (1983) 4-Aminobutyric acid methyl ester hydrochloride, a precursor of 4-aminobutyric acid. Biochem. Pharmacol. 32, 1093-1096.
4. Biondi, A., Capasso, A., Palagiano, F., Pistorio, E. and Sorrentino L. (1995) A new GABA mimetic drug exerts anticonvulsive activity after systemic administration. Eur. Neuropsychopharmacol. S.I. 5 (3), 389.
5. Bodor, N.S. (1989) Preparation of dihydropyridine-containing prodrugs for brain specific drug delivery. U.S.: Patent US 4 824 850, 25 April.
6. Capasso, A., Di Giannuario, A., Loizzo, A., Pieretti, S. and Sorrentino, L. (1991) Dexamethasone induces biphasic effect on morphine hypermotility in mice: A dose-related phenomenon. Life Sci. 49, 1411-1418.
7. Capasso, A., Di Giannuario, A., Loizzo, A., Pieretti, S. and Sorrentino, L. (1992) Central interaction of dexamethasone and RU-38486 on morphine antinociception in mice. Life Sci. 51, PL139-143.
8. Deverre, J.R., Loiseau, P., Couvreur, P., Letourneux, Y., Gayral, P. and Benoit, J.P. (1991) In vitro evaluation of filaricidal activity of GABA and 1,3 dipalmitoyl-2-(4-aminobutyryl)glycerol HCl: A diglyceride prodrug. J. Pharm. Pharmacol. 41, 191-193.
9. Enna, S.J., Stern, L.Z., Wastek, G.J. and Yakamura, H.I. (1977) Neurobiology and pharmacology of Huntington disease. Life Sci. 20, 205-212.
10. Fog, R. (1972) On the stereotypy and catalepsy: Studies on the effect of amphetamines and neuroleptics in rats. Acta Neurol. Scand. (Suppl.) 50, 3-66.
11. Galzigna, L., Garbin, L., Bianchi, M., and Marzotto, A. (1978) Properties of two derivatives of γ-aminobutyric acid (GABA) capable of abolishing cardiazol- and bicuculline-induced convulsions in the rat. Arch. Int. Pharmacodyn. 235, 73-85.
12. Haley, T.J. and McCormick, W.G. (1957) Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 12, 12-15.
13. Hecht, A. and Sciorring, E. (1979) Behavioral effects of low and high acute doses of morphine in solitary mice. Psychopharmacology, 64, 73-79.
14. Jacob, J.N., Shashoua, V.E., Campbell, A. and Baldessarrini, R.J. (1985) γ-Aminobutyric acid esters. 2. Synthesis, brain uptake and pharmacological properties of lipid esters of γ-aminobutyric acid. J. Med. Chem. 28, 106-110.
15. Jacob, J.N., Hesse, G.W. and Shashoua, V.E. (1990) Synthesis, brain uptake and pharmacological properties of a glyceryl lipid containing GABA and GABA-T inhibitor γ-vinyl GABA. J. Med. Chem. 33, 733-736.
16. Kahns, A.H. and Bundgaard, H. (1991) Hydrolysis kinetics of 1,3-benzoxazine-2,4-dione (a potential salicylamide prodrug) and various N-substituted derivatives. Acta Pharm. Nord. 3, 45-50.
17. Kahns, A.H., Moss, J. and Bundgaard, H. (1992) Improved oral bioavail-ability of salicylamide in rabbits by a 1,3-benzoxazine-2-4-dione prodrug. Int. J. Pharm. 78, 199-202.
18. Kiritsy-Roy, J.A., Standish, S.M. and Terry, L.C. (1989) Dopamine D-1 and D2 receptor antagonists potentiate analgesic and motor effects of morphine. Pharmacol. Biochem. Behav. 32, 717-721.
19. Lambert, D.M., Neuvens, L., Mergen, F., Gallez, B., Poupaert, J.H., Ghysel-Burton, J., Maloteaux, J.M. and Dumont, P. (1993) 1,3-Diacylaminopropan-2-ols and corresponding 2-acyl derivatives as drug carriers: Unexpected pharmacological properties. J. Pharm. Pharmacol. 45, 186-191.
20. Madrid, Y., Feigenbaun Langer, L., Brem, H. and Langer, R. (1991) New directions in the delivery of drugs and other substances to the central nervous system. Adv. Pharmacol. 22, 291-324.
21. B antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen. Br. J. Pharmacol. 103, 1303-1308.
22. Matsuyama, K., Yamashita, C., Noda, A., Goto, S., Noda, H., Ichimaru, Y. and Gomita, Y (1984) Evaluation of isonicotinoyl-γ-aminobutyric acid (GABA) and nicotinoyl-GAGA as prodrugs of GABA. Chem. Pharm. Bull. 32, 4089-4095.
23. Meldrum, B.S. and Hort, R.W. (1974) Neuronal inhibition mediated by GABA and patterns of convulsions in baboons with photosensitive epilepsy (Papio papio). In: Harris, P. and C. Mawdley (Eds.), Epilepsy, Churchill Livingstone, Edinburgh, pp. 55-64.
24. Nishino, N., Fujiwara, H., Noguchi-Kuno, S.A. and Tanaka, C. (1988) GABAA receptor but not muscarinic receptor density was decreased in the brains of patients with Parkinson's disease. Jpn. J. Pharmacol. 48, 331-339.
25. Palagiano, F., Bonina, F.P., Montenegro, L., Biondi, A., Capasso, A., Sorrentino L. and de Caprariis, P. (1996) Synthesis, stability and anticonvulsant activity of two new GABA prodrug. Die Pharmazie (in press).
26. Pieretti, S., Capasso, A., Di Giannuario, A., Loizzo, A. and Sorrentino, L. (1991) The interaction of peripherically and centrally administered dexamethasone and RU-38486 on morphine analgesia in mice. Gen. Pharmacol. 22, 829-933.
27. Pieretti, S., Di Giannuario, A., Capasso, A., Sorrentino, L. and Loizzo, A. (1994) Effects induced by cysteamine on chemically-induced nociception in mice. Life Sci. 54, 1091-1099.
28. Shashoua, V.E., Jacob, J.N., Ridge, R., Campbell, A. and Baldessarini, R.J. (1984) γ-Aminobutyric acid esters. 1. Synthesis, brain uptake and pharmacological studies of aliphatic and steroid esters of γ-aminobutyric acid. J. Med. Chem. 27, 659-664.
29. Tallarida, R.J. and Murray, R.B. (1987) Manual of pharmacological calculation with computer programs. Second Edition, Springer-Verlag.