The effect of coadministration of a cola beverage on the bioavailability of itraconazole in patients with acquired immunodeficiency syndrome

Current Therapeutic Research - Clinical and Experimental

Volumn 58, Issue 3, 1997, Pages 202-212

  Lange, David ^a   Pavao, Jennifer Hardin ^b   Jacqmin, Philippe ^c   Woestenborghs, Robert ^c   Ding, Cliff ^a   Klausner, Mark ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; HYDROXYITRACONAZOLE; ITRACONAZOLE;

ACIDIFICATION; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AREA UNDER THE CURVE; ARTICLE; BEVERAGE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; FEVER; FOOD DRUG INTERACTION; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; ORAL DRUG ADMINISTRATION; PHARYNGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH PH;

EID: 0030890505     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(97)80016-1     Document Type: Article

References (18)

1. Denning DW, Tucker RM, Hanson LH, Stevens DA. Treatment of invasive aspergillosis with itraconazole. Am J Med. 1989;86:791-800.
2. Olin BR. Drug Facts and Comparisons. 49th ed. St. Louis: JB Lippincott Co; 1995:2087-2090.
3. Wheat J, Hafner R, Wulfsohn M, et al. Prevention of relapse of histoplasmosis with itraconazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1993;118:610-616.
4. Cleary JD, Taylor JW, Chapman SW. Itraconazole in antifungal therapy. Ann Pharmacother. 1992;26:502-509.
5. Hay RJ, Dupont B, Graybill JR. First international symposium on itraconazole: A summary. Rev Infect Dis. 1987;9(Suppl 1):S1-S3.
6. Koll BS, Pawlecki JB. Fungal infection in the AIDS patients. Contemp Oncol. 1995;(special report):15-24.
7. Lake-Bakaar G, Beidas S, El-Sakir R, et al. Impaired gastric acid secretion in AIDS. Gastroenterology. 1987;92:1488. Abstract.
8. Lake-Bakaar G, Tom W, Lake-Bakaar D, et al. Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988;109: 471-473.
9. Tavitian A, Raufman J-P, Rosenthal LE, et al. Ketoconazole-resistant Candida esophagitis in patients with acquired immunodeficiency syndrome. Gastroenterology. 1986;90: 443-445.
10. Blum RA, D'Andrea DT, Florentino BM, et al. Increased gastric pH and the bioavailability of fluconazole and ketoconazole. Ann Intern Med. 1991;114:755-757.
11. Lake-Bakaar G, Tom W, Gupta N, et al. AIDS gastropathy: Reversible ketoconazole malabsorption. Gastroenterology. 1988;94:A247. Abstract.
12. Sutherland C, Murphy JE, Schleifer NH. The effects of two gastric acidifying agents on the pharmacokinetics of ketoconazole. In: Proceedings of the 18th Annual Midyear Clinical Meeting of the American Society of Hospital Pharmacists. Bethesda, Md: American Society of Hospital Pharmacists; 1983:P-297. Abstract.
13. Smith D, Van de Velde V, Woestenborghs R, Gazzard BG. The pharmacokinetics of oral itraconazole in AIDS patients. J Pharm Pharmacol. 1992;44:618-619.
14. Barone JA, Koh JG, Bierman RH et al. Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. Antimicrob Agents Chemother. 1993;37:778-784.
15. Data on file (solubility), Janssen Pharmaceutica, Titusville, New Jersey, 1995.
16. Centers for Disease Control. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR. 1992;41:1-9.
17. Woestenborghs R, Lorreyne W, Heykants J. Determinination of itraconazole in plasma and animal tissues by high-performance liquid chromatography. J Chromatogr. 1987; 413:332-337.
18. Data on file (itraconazole pharmacokinetics), Janssen Pharmaceutica, Titusville, New Jersey, 1995.