Immunoelectron microscopic localization of the HNK-1 carbohydrate epitope in the anterior segment of pseudoexfoliation and normal eyes

Current Eye Research

Volumn 16, Issue 3, 1997, Pages 231-238

  Kubota, Toshiaki ^a,b   Schlötzer Schrehardt, Ursula ^b   Inomata, Hajime ^a   Naumann, Gottfried O H ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

HNK 1 epitope; Immunoelectron microscopy; Pseudoexfoliation syndrome

Indexed keywords

CELL ADHESION MOLECULE; MONOCLONAL ANTIBODY;

AGED; ANTERIOR EYE CHAMBER; ARTICLE; AUTOPSY; BASEMENT MEMBRANE; CELL ULTRASTRUCTURE; CILIARY BODY; CILIARY BODY EPITHELIUM; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; ELASTIC FIBER; GLAUCOMA; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; IMMUNOREACTIVITY; IRIS; LENS CAPSULE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PSEUDOEXFOLIATION; TRABECULAR MESHWORK; UVEA;

EID: 0030890439     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.16.3.231.15404     Document Type: Article

References (32)

1. Kruse, J., Mailhammer, R., Wernecke, H., Faissner, A., Sommer, I., Goridis, C. and Schachner, M. (1984) Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1. Nature, 311, 153-155.
2. Chou, D. K. H., Ilyas, A. A., Evans, J. E., Costello, C., Quarles, R. H. and Jungalwala, F. B. (1986) Structure of sulfated glucuronyl glycolipids in the nervous system reacting with HNK-1 antibody and some IgM paraproteins in neuropathy. J. Biol. Chem. 261, 11717-11725.
3. Margolis, R. K., Ripellino, J. A., Goossen, R., Steinbrich, R. and Margolis, R. U. (1987) Occurrence of the HNK-1 epitope (3-sulfoglucuronic acid) in pc12 pheocromocytoma cells, chromaffin granule membranes, and chondroitin sulfate proteoglycans. Biochem. Biophys. Res. Commun. 145, 1142-1148.
4. Riopelle, R. J., McGarry, R. C. and Roder, J. C. (1986) Adhesion properties of a neuronal epitope recognized by the monoclonal antibody HNK-1. Brain Res. 367, 20-25.
5. Hall, H., Liu, L., Schachner, M. and Schmitz, B. (1993) The L2/HNK-1 carbohydrate mediates adhesion of neural cells to laminin. Eur. J. Neurosci. 5, 34-42.
6. Kivelä, T. (1986) Expression of the HNK-1 carbohydrate epitope in human retina and retinoblastoma: an immunohistochemical study with the anti-Leu-7 monoclonal antibody. Virchows Arch. A. 410, 139-146.
7. Perentes, E., Herbort, C. P., Rubinstein, L. J., Herman, M. M., Uffer, S., Donoso, L. A. and Collins, V. P. (1987) Immunohistochemical characterization of human retinoblastomas in situ with multiple markers. Am. J. Ophthalmol. 103, 647-658.
8. Uusitalo, M., Kivelä, T. and Tarkkanen, A. (1993) Identification of a novel element in the human eye: the inner connective tissue layer of the ciliary body characterized with antibodies to the HNK-1 epitope. Invest. Ophthalmol. Vis. Sci. 34, 2372-2381.
9. Uusitalo, M. and Kivelä, T. (1994) Differential distribution of the HNK-1 carbohydrate epitope in the vertebrate retina. Curr. Eye Res. 13, 697-704.
10. Uusitalo, M. (1995) The HNK-1 carbohydrate epitope in the anterior segment of the eye. The inner connective tissue layer of the human ciliary body as a distinct element. Acta Ophthalmol. 73, 363.
11. Uusitalo, M., Kivelä, T. and Tarkkanen, A. (1993) Immunoreactivity of exfoliation material for the cell adhesion-related HNK-1 carbohydrate epitope. Arch. Ophthalmol. 111, 1419-1423.
12. Uusitalo, M. (1994) Immunohistochemical localization of chondroitin sulfate proteoglycan and tenascin in the human eye compared with the HNK-1 epitope. Graefe's Arch. Clin. Exp. Ophthalmol. 232, 657-665.
13. Sugino, T. (1990) Exfoliative materials in the skin of patients with exfoliation syndrome. Acta Soc. Ophthalmol. Jpn. 94, 856-869.
14. Schlötzer-Schrehardt, U. M., Koca, M. R., Naumann, G. O. H. and Volkholz, H. (1992) Pseudoexfoliation syndrome: ocular manifestation of a systemic disorder? Arch. Ophthalmol. 110, 1752-1756.
15. Streeten, B. W., Li, Z.-Y., Wallace, R. N., Eagle, R. C. J. and Keshgegian, A. A. (1992) Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch. Ophthalmol. 110, 1757-1762.
16. Morrison, J. C. and Green, W. R. (1988) Light microscopy of the exfoliation syndrome. Acta Ophthalmol. 66, 5-27.
17. Schlötzer-Schrehardt, U. M., Dörfer, S. and Naumann, G. O. H. (1993) Corneal endothelial involvement in pseudoexfoliation syndrome. Arch. Ophthalmol. 111, 666-674.
18. Schlötzer-Schrehardt, U. M. and Naumann, G. O. H. (1994) A histopathological study of zonular instability in pseudoexfoliation syndrome. Am. J. Ophthalmol. 118, 730-743.
19. Schlötzer-Schrehardt, U. M. and Naumann, G. O. H. (1995) Trabecular meshwork in pseudoexfoliation syndrome with and without open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 36, 1750-1764.
20. Hietanen, J., Uusitalo, M., Tarkkanen, A. and Kivelä, T. (1995) Lectin and immunohistochemical comparison of glycoconjugates in the conjunctiva of patients with and without exfoliation syndrome. Brit. J. Ophthalmol. 79, 467-472.
21. Hietanen, J. and Tarkkanen, A. (1989) Glycoconjugates in exfoliation syndrome: a lectin histochemical study of the ciliary body and lens. Acta Ophthalmol. 67, 288-294.
22. Schlötzer-Schrehardt, U. M., Dörfler, S. and Naumann, G. O. H. (1992) Immunohistochemical localization of basement membrane components in pseudoexfoliation material of the lens capsule. Curr. Eye Res. 11, 343-355.
23. Li, Z.-Y., Streeten, B. W. and Yohai, N. (1989) Amyloid P protein in pseudoexfoliative fibrillopathy. Curr. Eye Res. 8, 217-227.
24. Streeten, B. W. (1993) Aberrant synthesis and aggregation of elastic components in pseudoexfoliative fibrillopathy: a unifying concept. New Trends Ophthalmol. 8, 187-196.
25. Asano, N., Schlötzer-Schrehardt, U. and Naumann, G. O. H. (1995) A histopathologic study of iris changes in pseudoexfoliation syndrome. Ophthalmology, 102, 1279-1290.
26. Uusitalo, M., Kivelä, T. and Tarkkanen, A. (1994) The HNK-1 epitope in the inner connective tissue layer of the human ciliary body in exfoliation syndrome and various types of glaucoma. Graefe's Arch. Clin. Exp. Ophthalmol. 232, 8-15.
27. Küchle, M., Nguyen, N. X., Hannappel, E. and Naumann, G. O. H. (1995) The blood-aqueous barrier in eyes with pseudoexfoliation syndrome. Ophthalmic Res. 27 (Suppl. 1), 136-142.
28. Streeten, B. W., Gibson, S. A. and Li, Z.-Y. (1986) Lectin binding to pseudoexfoliative material and the ocular zonules. Invest. Ophthalmol. Vis. Sci. 27, 1516-1521.
29. Krueger, R. C., Hennig, A. K. and Schwartz, N. B. (1992) Two immunologically and developmentally distinct chondroitin sulfate proteoglycans in embryonic chick brain. J. Biol. Chem. 267, 12149-12161.
30. Gowda, D. C., Margolis, R. U. and Margolis, R. K. (1989) Presence of the HNK-1 epitope on poly (N-acetyllactosaminyl) oligosaccharides and identification of multiple core proteins in the chondroitin sulfate proteoglycans of brain. Biochemistry, 28, 4468-4474.
31. Nichol, K. A., Everett, A. W., Schulz, M. and Bennett, M. R. (1994) Retinal ganglion cell survival in vitro maintained by a chondroitin sulfate proteoglycan from the superior colliculus carrying the HNK-1 epitope. J. Neurosci. Res. 37, 623-632.
32. Loveless, R. W., Floyd-O'Sullivan, G., Raynes, J. G., Yuen, C.-T. and Feizi, T. (1992) Human serum amyloid P is a multispecific adhesive protein whose ligands include 6-phosphorylated mannose and the 3-sulphated saccharides galactose, N-acetylgalactosamine and glucuronic acid. EMBO J. 11, 813-819.