Intranasal administration of Schistosoma mansoni adult worm antigen in combination with cholera toxin induces a Th2 cell response

Parasite Immunology

Volumn 19, Issue 4, 1997, Pages 183-190

  Akhiani, A A ^a   Nilsson, L A ^a   Ouchterlony, O ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cholera toxin; Cytokines; Immune response; Schistosoma mansoni

Indexed keywords

CHOLERA TOXIN; INTERLEUKIN 4; INTERLEUKIN 5; PARASITE ANTIGEN; TRYPANOSOMA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; IMMUNIZATION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; T LYMPHOCYTE SUBPOPULATION;

EID: 0030890147     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1997.d01-196.x     Document Type: Article

References (24)

1. Abraham E., Freitas A.A., & Coutinho A.A. (1990) Purification and characterization of intraparenchymal lung lymphocytes. Journal of Immunology 144, 2117-2122
2. Akhiani A.A., Nilsson L.-Å. & Ouchterlony Ö. (1991) Comparative antigen analysis of different life stages of Schistosoma mansoni by crossed immunoelectrophoresis. International Archives of Allergy and Applied Immunology 95, 266-272
3. Akhiani A.A., Nilsson L.-Å. & Ouchterlony Ö. (1993) Effect of cholera toxin on vaccine-induced immunity and infection in murine schistosomiasis mansoni. Infection and Immunity 61, 4919-4924
4. Bomford R. (1989) Adjuvants for anti-parasite vaccines. Parasitology Today 5, 41-46
5. Couissinier-Paris P. & Dessein A.J. (1995) Schisrosoma-specific helper T cell clones from subjects resistant to infection by Schistosoma mansoni are Th0/2. European Journal of Immunology 25, 2295-2302
6. Elson C.O. & Ealding W. (1984) Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. Journal of Immunology 132, 2736-2741
7. Hörnquist E. & Lycke N. (1993) Cholera toxin adjuvant greatly promotes antigen priming of T cells. European Journal of Immunology 23, 2136-2143
8. James S.L., Natovitz P.C., Farrar W.L. et al. (1984) Macrophages as effector cells of protective immunity in murine schistosomiasis: macrophage activation in mice vaccinated with radiation-attenuated cercariae. Infection and Immunity 44, 569-575
9. James S.L. (1985) Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine is dependent on the method of antigen presentation. Journal of Immunology 134, 1956-1960
10. James S.L. (1986) Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. III. Correlation of resistance with induction of activated larvicidal macrophages. Journal of Immunology 136, 3872-3877
11. James S.L., & Pearce E. J. (1988) The influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis. Journal of Immunology 140, 2753-2759
12. Khalife J., Capron M., Capron A. et al. (1986) Immunity in human schistosomiasis mansoni. Regulation of protective immune mechanisms by IgM blocking antibodies. Journal of Experimental Medicine 164, 1626-1640
13. Liang X., Lamm M.E. & Nedrud J.G. (1988) Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and respiratory immunity against Sendai virus. Journal of Immunology 141, 1495-1501
14. Lowry O.H., Rosebrough N.J., Farr A.L. et al. (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-275
15. Lycke N. & Holmgren J. (1986) Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 59, 301-308
16. Mosmann T.R. & Coffman R.L. (1989) Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7, 145-173
17. Nedrud J.G., Liang X., Hague N. et al. (1987) Combined oral/nasal immunization protects mice from Sendai virus infection. Journal of Immunology 139, 3484-3492
18. Omer-Ali P., Magee A.I., Kelly C. et al. (1986) A major role for carbohydrate epitopes preferentially recognized by chronically infected mice in the determination of Schistosoma mansoni schistosomulum surface antigenicity. Journal of Immunology 137, 3601-3607
19. Oswald I.P., Gazzinelli R.T., Sher A. et al (1992) IL-10 synergizes with IL-4 and TGF-β to inhibit macrophage cytotoxic activity. Journal of Immunology 148, 3578-3582
20. Roberts M., Bacon A., Rappuoli R. et al. (1995) A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/ 129G, is an effective mucosal adjuvant for intranasally delivered proteins. Infection and Immunity 63, 2100-2108
21. Sinder D.P., Marshall J.S., Perdue M.H. et al. (1994) Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein antigen and cholera toxin. Journal of Immunology 153, 647-657
22. Tamura S., Kurata H., Funato H. et al. (1989) Protection against influenza virus infection by a two-dose regimen of nasal vaccination using vaccines combined with cholera toxin B subunit. Vaccine 1, 314-320
23. Tamura S.-I., Shoji Y., Hasiguchi K. et al. (1994) Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin. Vaccine 12, 1238-1240
24. Wilson R.A., Coulson P.S. & Dixon B. (1986) Migration of the schistosomula of Schistosoma mansoni in mice vaccinated with radiation-attenuated cercariae, and normal mice: an attempt to identify the timing and site of parasite death. Parasitology 92, 101-116