Interaction of sympathetic vasoconstriction and antidromic vasodilatation in the control of skin blood flow

Experimental Brain Research

Volumn 113, Issue 3, 1997, Pages 402-410

  Habler H J ^a   Wasner, G ^a   Janig W ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Antidromic vasodilatation; Axon reflex; Sympathetic nervous system; Vasoconstriction

Indexed keywords

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANTIDROMIC STIMULATION; ARTICLE; DORSAL ROOT; ELECTROSTIMULATION; FEMALE; LASER DOPPLER FLOWMETRY; LUMBAR SPINE; MALE; NERVE STIMULATION; NONHUMAN; POSTGANGLIONIC NERVE; PRIORITY JOURNAL; RAT; SENSORY NERVE; SKIN BLOOD FLOW; SYMPATHETIC NERVE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; BLOOD FLOW VELOCITY; FEMALE; MALE; RATS; RATS, WISTAR; SKIN PHYSIOLOGY; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASODILATION;

EID: 0030890056     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005594     Document Type: Article

References (44)

1. Baron R, Jänig W, Kollmann W (1988) Sympathetic and afferent somata projecting in hindlimb nerves and the anatomical organization of the lumbar sympathetic nervous system of the rat. J Comp Neurol 275:460-468
2. Bayliss WM (1901) On the origin from the spinal cord of the vaso-dilator fibres of the hind-limb, and on the nature of these fibres. J Physiol (Lond) 26:173-209
3. Boczek-Funcke A, Dembowsky K, Häbler H-J, Jänig W, Michaelis, M (1993) Spontaneous activity, conduction velocity and segmental origin of different classes of thoracic preganglionic neurons projecting into the cat cervical sympathetic trunk. J Auton Nerv Syst 43:189-200
4. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54-56
5. Brun-Pascaud M, Gaudebout C, Blayo MC, Pocidalo JJ (1982) Arterial blood gases and acid-base status in awake rats. Respir Physiol 48:45-57
6. Cervero F, Gilbert R, Hammond RGE, Tanner J (1993) Development of secondary hyperalgesia following non-painful thermal stimulation of the skin: a psychophysical study in man. Pain 54:181-189
7. Chahl LA (1991) Antidromic vasodilatation and neurogenic inflammation. In: Bell C (ed) Novel peripheral neurotransmitters. Pergamon, New York, pp 161-192
8. Delay-Goyet P, Satoh H, Lundberg JM (1992) Relative involvement of substance P and CGRP mechanisms in antidromic vasodilation in the rat skin. Acta Physiol Scand 146:537-538
9. Franco-Cereceda A, Henke H, Lundberg JM, Petermann JB, Hökfelt T, Fischer JA (1987) Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Peptides 8:399-410
10. Fujimori A, Saito A, Kimura S, Watanabe T, Uchiyama Y, Kawasaki H, Goto K (1989) Neurogenic vasodilation and release of calcitonin gene-related peptide (CGRP) from perivascular nerves in the rat mesenteric artery. Biochem Biophys Res Comm 165:1391-1398
11. Gardiner SM, Compton AM, Kemp PA, Bennett T, Bose C, Foulkes R, Hughes B (1990) Antagonistic effect of human α-CGRP [8-37] on the in vivo regional haemodynamic actions of human α-CGRP. Biochem Biophys Res Commun 171:938-943
12. Gibbins IL, Furness JB, Costa M, Maclntyre I, Hillyard CJ, Girgis S (1985) Colocalization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs. Neurosci Lett 57:125-130
13. Girgis SI, MacDonald DWR, Stevenson JC, Bevis PJR, Lynch C, Wimalawansa SJ, Self CH, Morris HR, Maclntyre I (1985) Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene. Lancet 11:14-16
14. Hübler H-J, Wasner G (1995) Interaction of sympathetic vasoconstriction and antidromic vasodilatation in rat skin. Pflügers Arch 429 [Suppl]:R473
15. Häbler H-J, Jänig W, Krummel M, Peters OA (1994) Reflex patterns in postganglionic neurons supplying skin and skeletal muscle of the rat hindlimb. J Neurophysiol 72:2222-2236
16. Hallin RG, Torebjörk HE (1974) Single unit sympathetic activity in human skin nerves during rest and various manoeuvres. Acta Physiol Scand 92:303-317
17. Han S-P, Naes L, Westfall TC (1990) Inhibition of periarterial nerve stimulation-induced vasodilation of the mesenteric arterial bed by CGRP (8-37) and CGRP receptor desensitization. Biochem Biophys Res Commun 168:786-791
18. Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739-768
19. Holzer P (1992) Peptidergic sensory neurons in the control of vascular functions: mechanisms and significance in the cutaneous and splanchnic vascular beds. Rev Physiol Biochem Pharmacol 121:49-146
20. Hornyak ME, Naver HK, Rydenhag B, Wallin BG (1990) Sympathetic activity influences the vascular axon reflex in the skin. Acta Physiol Scand 139:77-84
21. 8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin. Br J Pharmacol 104:738-742
22. Jänig W (1985) Organization of the lumbar sympathetic outflow to skeletal muscle and skin of the cat hindlimb and tail. Rev Physiol Biochem Pharmacol 102:119-213
23. Jänig W, Lisney SJW (1989) Small diameter myelinated afferents produce vasodilatation but not plasma extravasation in rat skin. J Physiol (Lond) 415:477-486
24. Kawasaki H, Takasaki K, Saito A, Goto K (1988) Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 335:164-167
25. Kawasaki H, Nuki C, Saito A, Takasaki K (1990a) Role of calcitonin gene-related peptide containing nerves in the vascular adrenergic neurotransmission. J Pharmacol Exp Ther 252:403-409
26. Kawasaki H, Nuki C, Saito A, Takasaki K (1990b) Adrenergic modulation of calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric resistance vessel. Brain Res 506:287-290
27. Kerezoudis NP, Olgart L, Edwall L (1994) CGRP (8-37) reduces the duration but not the maximal increase of antidromic vasodilation in dental pulp and lip of the rat. Acta Physiol Scand 151:73-81
28. Kruger L, Silverman JD, Mantyh PW, Sterini C, Brecha NC (1989) Peripheral patterns of calcitonin gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J Comp Neurol 280:291-302
29. Lewis T (1927) The blood vessels of the human skin and their responses. Shaw, London
30. Li YJ, Duckles SP (1991) Differential effect of neuropeptide Y and opioids on neurogenic responses of the perfused rat mesentery. Eur J Pharmacol 195:365-372
31. Lisney SJW, Bharali LAM (1989) The axon reflex: an outdated idea or a valid hypothesis? News Physiol Sci 4:45-48
32. Lynn B, Cotsell B (1992) Blood flow increases in the skin of the anaesthetized rat that follow antidromic sensory nerve stimulation and strong mechanical stimulation. Neurosci Lett 137:249-252
33. Lynn B, Schütterle S, Pierau F-K (1996) The vasodilator component of neurogenic inflammation is caused by a special subclass of heat-sensitive nociceptors in the skin of the pig. J Physiol (Lond) 494:587-593
34. Macefield VG, Wallin BG, Vallbo AB (1994) The discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves. J Physiol (Lond) 481:799-809
35. Magerl W, Szolcsanyi J, Westerman RA, Handwerker HO (1987) Laser Doppler measurements of skin vasodilation elicited by percutaneous electrical stimulation of nociceptors in humans. Neurosci Lett 82:349-354
36. Maynard KI, Saville VL, Burnstock G (1990) Sensory-motor neuromodulation of sympathetic vasoconstriction in the rabbit central ear artery. Eur J Pharmacol 187:171-182
37. Moritoki H, Takase H, Tanioka A (1990) Dual effect of capsaicin on responses of the rabbit ear artery to field stimulation. Br J Pharmacol 99:152-156
38. Ochoa JL, Yarnitsky D, Marchettini P, Dotson R, Cline M (1993) Interactions between sympathetic vasoconstrictor outflow and C nociceptor-induced antidromic vasodilatation. Pain 54:191-196
39. Stricker MS (1876) Untersuchungen über die Gefässnerven-Wurzeln des Ischiadicus. Sitzungsber Kaiserl Akad Wissensch Wien 3:173-185
40. Szolcsányi J (1988) Antidromic vasodilatation and neurogenic inflammation. Agents Actions 23:4-11
41. Szolcsányi J, Pinter E, Pethö G (1992) Role of unmyelinated afferents in regulation of microcirculation and its chronic distorsion after trauma and damage. In: Jänig W, Schmidt RF (eds) Reflex sympathetic dystrophy: pathophysiological mechanisms and clinical implications. VCH, Weinheim, pp 245-261
42. Vallbo A, Olausson H, Wessberg J, Norsell U (1993) A system of unmyelinated afferents for innocuous mechanoreception in the human skin. Brain Res 628:301-304
43. Zaidi M, Bevis PJR, Lynch C, Stevenson JC, MacIntyre I (1985) Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117:283-284
44. Zochodne DW, Ho LT (1991) Influence of perivascular peptides on endoneurial blood flow and microvascular resistance in the sciatic nerve of the rat. J Physiol (Lond) 444:615-630