Dissection of human il-5 promoter − essential role of cleo element in human il-5 gene transcription

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 272-274

  Mori, Akio ^a   Kaminuma, Osamu ^a   Mikami, Tadashi ^a   Hoshino, Akihiko ^a   Ohmura, Takeo ^a   Miyazawa, Keiji ^a   Suko, Matsunobu ^a   Okudaira, Hirokazu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Gene transcription; IL 5; NF AT; Promoter; T cell

Indexed keywords

BETA GALACTOSIDASE; INTERLEUKIN 5; LUCIFERASE; MESSENGER RNA;

ASTHMA; CONFERENCE PAPER; CONTROLLED STUDY; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SITE DIRECTED MUTAGENESIS; STATISTICAL ANALYSIS; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-5; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC;

EID: 0030889850     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237570     Document Type: Article

References (8)

1. Gleich GJ, Adolphson CR: The eosinophilic leukocyte: Structure and function, Adv Immunol 1986;39:177-253.
2. Kay AB: 'Helper' (CD4+) T cells and eosinophils in allergy and asthma, Am Rev Respir Dis 1992;145:S22-S26.
3. Mori A, Suko M, Nishizaki Y, Kaminuma O, Kobayashi S, Matsuzaki G, Yamamoto K, lto K, Tsuruoka N, Okudaira H: lnterleukin-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A, hit Immunol 1995:7:449-457.
4. Mori A, Suko M, Kaminuma O, Inoue S, Ohm-ura T, Nishizaki Y, Nagahori T, Asakura Y, Hoshino A, Okumura Y, Sato G, lto K, Okudaira H: IL-15 promotes cytokine production of human helper T cells, J Immunol 1996; 156: 2400-2405.
5. Mori A, Inoue S, Mikami T, Kaminuma O, Ohmura T, Nishizaki Y, Asakura Y, Suko M, Itoh K, Okudaira H: Analysis of human IL-5 gene transcription by T cell clones and hybrid-omas, Int Arch Allergy Immunol 1995:107: 366-367.
6. Mori A, Suko M, Kaminuma O, Nishizaki Y, Mikami T, Ohmura T, Iloshino A, Inoue S, Tsuruoka N, Okumura Y, lto K, Okudaira I I: A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones, Int Immunol 1996:8:1889-1895.
7. Mori A, Suko M, Kaminuma O, Ohmura T, Hoshino A, Miyazawa K, Okudaira H: Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases, J Allergy Clin Immunol, in press
8. Arai N, Naito Y, Watanabe M, Masuda LS, Ya-maguchi Y, Tsuboi A, Heike T, Matsuda I, Yoko-ta K, Koyano N, Lee HJ, Muramatsu M, Yokota T, Arai K: Activation of lymphokine genes in T cells: Role of cis-acting DNA elements that respond toT cell activation signals, Phannacol, Ther, 1992:55:303-318