Generation of catalytic RNAs by rolling transcription of synthetic DNA Nanocircles

Nature Biotechnology

Volumn 15, Issue 3, 1997, Pages 273-277

  Daubendiek, Sarah L ^a   Kool, Eric T ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

ASBV viroid; Convergent synthesis; Hammerhead ribozyme; Rolling circle

Indexed keywords

RIBOZYME;

ARTICLE; BASE PAIRING; CATALYSIS; DNA SYNTHESIS INHIBITION; DNA TRANSCRIPTION; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RNA SYNTHESIS; TARGET CELL; VIRUS GENOME;

DNA, CIRCULAR; DNA, RECOMBINANT; GENETIC VECTORS; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; VIROIDS;

EID: 0030889291     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0397-273     Document Type: Article

References (24)

1. Aiyar, S.E., Helmann, J.D., and deHaseth, P.L. 1994. A mismatch bubble in double-stranded DNA suffices to direct precise transcription initiation by Escherichia coli RNA polymerase. J. Biol. Chem. 269:13179-13184.
2. Mollegaard, N.E., Buchardt, O., Egholm, M., and Nielsen, P.E. 1994. Peptide nucleic acid. DNA strand displacement loops as artificial transcription promoters. Proc. Natl. Acad. Sci. USA 91:3892-3895.
3. Daube, S.S. and von Hippel, P.H. 1992. Functional transcription elongation complexes from synthetic RNA-DNA bubble duplexes. Science 258:1320-1324.
4. Chamberlin, M., McGrath, J., and Waskell, L. 1970. New RNA polymerase from Escherichia coli infected with bacteriophage T7. Nature 228:227-230.
5. Chamberlin, M. and Ring, J. 1973. Characterization of T7-specific ribonucleic acid polymerase. II. Inhibitors of the enzyme and their application to the study of the enzymatic reaction. J. Biol. Chem. 248:2245-2250.
6. Kadesch, T.R. and Chamberlin, M.J. 1982. Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template. J. Biol. Chem. 257:5286-5295.
7. Krupp, G. 1988. RNA synthesis: strategies for the use of bacteriophage RNA polymerases. Gene 72:75-89.
8. Daubendiek, S.L, Ryan, K., and Kool, E.T. 1995. Rolling circle RNA synthesis: circular oligonucleotides as efficient substrates for T7 RNA polymerase. J. Am. Chem. Soc. 117:7818-7819.
9. Daubendiek, S.L. and Kool, E.T. 1996. Manuscript submitted.
10. Symons, R.H. 1981. Avocado sunblotch viroid: primary sequence and proposed secondary structure. Nucleic Acids Res. 9:6527-6537.
11. Hutchins, C.J., Rathjen, P.D., Forster, A.C., and Symons, R.H. 1986. Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid. Nucleic Acids Res. 14:3627-3640.
12. Rubin, E., Rumney, S., and Kool, E.T. 1995. Convergent DNA synthesis. A nonenzymatic dimerization approach to ciruclar oligonucleotides. Nucleic Acids Res. 23:3547-3553.
13. Milligan, J.F., Groebe, D.R., Witherell, G.W., and Uhlenbeck, O.C. 1987. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res. 15:8783-8798.
14. Uhlenbeck, O.C. 1987. A small catalytic oligoribonucleotide. Nature 328:596-600
15. Haseloff, J. and Gerlach, W.L. 1988. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 344:585-591
16. Symons, R.H. 1992. Small catalytic RNAs. Annu. Rev. Biochem. 61:641-671
17. Long, D.M. and Uhlenbeck, O.C. 1993. Self-cleaving catalytic RNA. FASEBJ. 7:25-30.
18. Sarver, N., Cantin, E.M., Chang, P.S., Zaia, J.A., Ladne, P., Stephens, D.A., and Rossi, J.J. 1990. Ribozymes as potential anti-HIV-1 therapeutic agents. Science 247:1222-1225.
19. Ohkawa, J., Yuyama, N., Takebe, Y, Nishikawa, S., and Taira, K. 1993. Importance of independence in ribozyme reactions: kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 90:11302-11306.
20. Dzianott, A.M. and Bujarski, J.J. 1989. Derivation of an infectious viral RNA by autolytic cleavage of in vitro transcribed viral cDNAs. Proc. Natl. Acad. Sci. USA 86:4823-4827.
21. Grosshans, OA. and Cech, T.R. 1991. A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3´ end blocked for transesterification. Nucleic Acids Res. 19:3875-3880.
22. Taira, K., Nakagawa, K., Nishikawa, S., and Furukawa, K. 1991. Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors. Nucleic Acids Res. 19:5125-5130.
23. Sousa, R., Chung, Y.J., Rose, J.R, and Wang, B.-C. 1993. Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution. Nature 364:593-599.
24. Darst, S.A., Kubalek, E.W., and Kornberg, R.D. 1989. Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography. Nature 340:730-732.