Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library

Biochemistry

Volumn 36, Issue 10, 1997, Pages 3018-3026

  Charlton, Josephine ^a   Kirschenheuter, Gary P ^a   Smith, Drew ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; DNA; ELASTASE INHIBITOR; ELASTIN; LEUKOCYTE ELASTASE; PHOSPHONIC ACID DERIVATIVE; VALINE;

ARTICLE; CONTROLLED STUDY; DNA LIBRARY; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INACTIVATION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; PRIORITY JOURNAL;

CATHEPSINS; FLUORESCEIN; FLUORESCEINS; FLUORESCENCE; GENE LIBRARY; HUMANS; KINETICS; LEUKOCYTE ELASTASE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NEUTROPHILS; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHONIC ACIDS; SALTS; SEQUENCE ANALYSIS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; VALINE;

EID: 0030889231     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962669h     Document Type: Article

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