Induction of the multidrug-transporter P-glycoproein by 3'-azido-3'-deoxythymidine (AZT) treatment in tumor cell lines

Journal of Experimental and Clinical Cancer Research

Volumn 16, Issue 1, 1997, Pages 29-32

  Signoretti, C ^a   Romagnoli, G ^a   Turriziani, O ^b,c   Antonelli, G ^b,c   Dianzani, F ^b,c   Cianfriglia, M ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b Institute of Virology   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

AZT; multiple drug resistance; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; ZIDOVUDINE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0030889161     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Germann U.A., Pastan I., Gottesman M.M.: P-glycoproteins: mediators of multidrug resistance. Semin. Cell Biol. 4: 63-76, 1993.
2. Childs S., Ling V.: The MDR superfamily of genes and its biological implications. In: De Vita V.T., Heimann S., Rosenberg S.A., eds. Important Advances in Oncology. Philadelphia: J.B. Lippincott Company, 1994: 21-36.
3. Kartner N., Riordan J.R., Ling V.: Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221: 1058-1088, 1983.
4. Schinkel A.H., Borst P.: Multidrug resistance mediated by P-glycoproteins. Semin. Cancer Biol. 2: 213-226, 1991.
5. Ueda K., Cardarelli C., Gottesman M.M., Pastan I.: Expression of a full-length cDNA for the human «MDR1» gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. (USA) 84: 3004-3008, 1987.
6. Chaudary P.M., Roninson I.B.: Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl. Cancer Inst. 85: 632-639, 1993.
7. Hermans P., Clumeck N.: Kaposi's sarcoma in patients infected with human virus (HIV): an overview. Cell. Mol. Biol. 3: 357-364, 1995.
8. Mosmann T.: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63, 1983.
9. Denizot F., Lang R.: Rapid colorimetric assay for cell growth and survival. J. Immunol. Methods 89: 271-277, 1986.
10. Cianfriglia M., Willingham M.C., Tombesi M., Scagliotti G.V., Falasca G., Chersi A.: P-glycoprotein epitope mapping. Identification of a linear human-specific epitope in the fourth loop of the P-glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multidrug resistance cells. J. Cancer 56: 153-160, 1994.
11. Cenciarelli C., Currier S.J., Willingham M.C.; et al.: Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product (P-glycoprotein); determination of P-glycoprotein expression in multi-drug-resistance KB and CEM variants. J. Cancer 47: 533-544, 1991.
12. Hamada H., Tsuruo T.: Functional role for the 170-180 Kd glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. Proc. Natl. Acad. Sci. (USA) 83: 7785-7789, 1986.