Green tea catechins (EGCG and EGC) have modulating effects on the activity of doxorubicin in drug-resistant cell lines

Anti-Cancer Drugs

Volumn 8, Issue 3, 1997, Pages 265-268

  Stammler, Gerd ^a   Volm, Manfred ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

( ) epigallocatechin; ( ) epigallocatechin gallate; doxorubicin; green tea; modulation

Indexed keywords

DOXORUBICIN; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROTEIN KINASE C;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; COLON CARCINOMA; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RESISTANCE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA 180; SENSITIZATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATECHIN; CELL DIVISION; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; HUMANS; MICE; SARCOMA 180; TEA; TUMOR CELLS, CULTURED;

EID: 0030889051     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199703000-00007     Document Type: Article

References (23)

1. Gao YT, Mc Laughlin JK, Blot WJ, Ji BT, Dai Q, Frameni JF. Reduced risk of esophageal cancer associated with green tea consumption. J Natl Cancer Inst 1994; 86: 855-8.
2. Oguni I, Cheng SJ, Lin PZ, Hara Y. Protection against cancer risk by Japanese green tea. Prev Med 1992; 21: 332.
3. Kato I, Tominaga S, Matsuura A, Yoshii Y, Shivai M, Kohayshi S. A comparative case-control study of colorectal cancer and adenoma. Jpn J Cancer Res 1990; 81: 1101-8.
4. Huang MT, Ho CT, Wang ZY, et al. Inhibitory effects of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 1992; 13: 947-54.
5. Fujiki H, Suganuma M, Suguri H, et al. New antitumor promotors: (-)-epigallocatechinegallate and sarcophytols A and B. Basic Life Sci 1990; 52: 205-12.
6. Narasiwa T, Fukaura Y. A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 1993; 84: 1007-9.
7. Komori A, Yatsunami J, Okabe S, et al. Anticarcinogenic activity of green tea polyphenols. Jpn J Clin Oncol 1993; 23: 186-90.
8. Khan SG, Katiyar SK, Agarwal R, Mukhtar H. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res 1992; 52: 4050-2.
9. Volm M, Pommerenke E. Associated expression of protein kinase C with resistance to doxorubicin in human lung cancer. Anticancer Res 1995; 15: 463-6.
10. Sinha BK, Dusre L, Collins C, Myers CE. Resistance of paraquat and adriamycin in human breast tumour cells: role of free radical formation. Biochim Biophys Acta 1989; 1010: 304-10.
11. Boyle WJ, Smeal T, Defize LHK. Activation of protein-kinase-C decreases phosphorylation of c-jun at sites that negatively regulate its DNA-binding. Cell 1991; 64: 573-84.
12. Morrow CS, Cowan, KK, Goldsmith ME. Structure of the human genomic glutathione S-transferase-pi gene. Gene 1989; 75: 3-11.
13. Bhushan A, Abramson R, Chiu JF, Tritton TR. Expression of c-fos in human and murine multidrug resistant cells. Mol Pharmacol 1992; 42: 69-71.
14. Binteruy B, Smeal T, Karin M. Ha-Ras augments C-Jun activity and stimulates phosphorylation of its activation domain. Nature 1991; 351: 122-7
15. Chambers T, McAvoy E, Jacobs J, Eilon G. PKC phosphorylates P-glycoprotein in MDR human KB carcinoma cells. J Biol Chem 1990; 265: 7679-86.
16. + -phospholipid-dependent protein kinase (protein kinase C). Biochem Biophys Res Commun 1989; 162: 903-7.
17. Sahyoun N, Wolf M, Besterman J, et al. Protein kinase C phophorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells. Proc Natl Acad Sci USA 1986; 83: 1603-7.
18. Efferth T, Volm M. Reversal of doxorubicin-resistance in sarcoma 180 tumor cells by inhibition of different resistance mechanisms. Cancer Lett 1993; 70: 197-202.
19. Sadzuka Y, Sugiyama T, Miyagishima A, Nozawa Y, Hirota S. The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin. Cancer Lett 1996; 105: 203-9.
20. Lin YL, Juan JM, Chen YL, Liang YC, Lin JK. Composition of polyphenols in fresh tea leaves and associations of their oxygen-radical absorby capacity with antiproliferative actions in fibroblast cells. J Agric Food Chem 1996; 44: 1387-94.
21. Ho CT, Chen Q, Shi H, Zhang KQ, Rosen RT. Antioxidative effect of polyphenol extract prepared from various Chinese teas. Prev Med 1992; 21: 520-5.
22. Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP, Riceevans C. Polyphenolic flavanols as scavengers of aqueous-phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys 1995; 322: 339-46.
23. Chambers TC, Zheng B, Kuo, JF. Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells. Mol Pharmacol 1992; 41: 1008-15.