Mass spectrometric studies on the inhibition of TEM-2β-lactamase by clavulanic acid derivatives

Journal of Antibiotics

Volumn 50, Issue 2, 1997, Pages 184-185

  Brown, Roland P A ^a   Aplin, Robin T ^a   Schofield, Christopher J ^a   Frydrych, Colin H ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLAVULANIC ACID; PENICILLINASE;

ARTICLE; DRUG MECHANISM; ENZYME INHIBITION; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 0030888338     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.184     Document Type: Article

References (8)

1. READING, C. & M. COLE: Clavulanic acid: A beta-lactamase inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrob. Agents Chemotherap. 11: 852-857, 1977
2. READING, C. & P. HEPBURN: The inhibition of staphylococcal β-lactamase by clavulanic acid. Biochem. J. 179: 67-76, 1979
3. CARTWRIGHT, S. J. & A. F. W. COULSON: A semi-synthetic penicillinase inactivator. Nature 278: 360-361, 1989
4. CHARNAS, R. L. & J. R. KNOWLES: Inactivation of RTEM β-lactamase from Escherichia coli by clavulanic acid and 9-deoxyclavulanic acid. Biochemistry 20: 3214-3219, 1981
5. KNOWLES, J. R.: Penicillin resistance: The chemistry of β-lactamase inhibition. Acc. Chem. Res. 18: 97-104, 1985 and references therein.
6. CHEN, C. C. H. & O. HERZBERG: Inhibition of β-lactamase by clavulanate trapped intermediates in crystallographic studies. J. Mol. Biol. 224: 1103-1113, 1992
7. BROWN, R. P. A.; R. T. APLIN & C. J. SCHOFIELD: Inhibition of TEM-2β-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionisation mass spectrometry. Biochemistry 35: 12421-12432, 1996
8. IMTIAZ, U.; E. BILLINGS, J. R. KNOX, S. A. MANAVATHU, A. LERNER & S. MOBASHERY: Inactivation of class A β-lactamases by clavulanic acid: The role of arginine-244 in a proposed nonconcerted sequence of events. J. Amer. Chem. Soc. 115:4435-4442, 1993