Chemical, dissolution stability and microscopic evaluation of suspensions of ibuprofen and sustained release ibuprofen-wax microspheres

Journal of Microencapsulation

Volumn 14, Issue 3, 1997, Pages 357-377

  Adeyeye, C M ^a   Price, J C ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Aging; Ibuprofen; Physical stability; Suspending agents; Sustained release; Wax microspheres

Indexed keywords

IBUPROFEN; METHYLCELLULOSE; MICROCRYSTALLINE WAX; MICROSPHERE; SUSPENDING AGENT; WAX;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROENCAPSULATION; PARTICLE SIZE; PH; SUSPENSION; SUSTAINED DRUG RELEASE; SYRUP; TEMPERATURE SENSITIVITY;

EID: 0030888113     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652049709051139     Document Type: Article

References (15)

1. ADEYEYE, C. M., and PRICE, J. C., 1991, Development and evaluation of sustained release ibuprofen-wax microspheres. I. Effect of formulation variables on physical characteristics. Pharmaceutical Research, 8(1), 1377-1383.
2. ADEYEYE, C. M., and PRICE, J. C., 1994, Development and evaluation of sustained release ibuprofen-wax microspheres: II. In vitro dissolution studies. Pharmaceutical Research, 11(4), 575-579.
3. DALAL, P. S., NARURKAR, M. M., and MILIND, M., 1991, In vitro and in vivo Evaluation of Sustained Release Suspensions of Ibuprofen. International Journal of Pharmaceutics, 73(2), 157-162.
4. DONDONI, A., DALL'OCCA, T., FANTINI, G., MEDICI, A., PEDRINI, P., and ROSETTI, V., 1986, Studies on the actual and potential impurities in ibuprofen. Farmaco-Ed. Pr., 42, 237-244.
5. FEINBERG, M., 1970, The Dating of Pharmaceuticals, edited by J. J. Windheuser and W. L. Blockstein (University Extension, University of Wisconsin, Madison, Wisconsin), pp. 144.
6. FUNG, H., 1979, Chemical Kinetics and Drug Stability. Modern Pharmaceutics, edited by G. S. Banker and C. T. Rhodes (Marcel Dekker, New York), pp. 227, 237.
7. GARRETT, E. R., 1962, Prediction of stability of drugs and pharmaceutical preparations: Journal of Pharmaceutical Sciences, (9), 811-833.
8. GENNARO, A. R., 1980, Natural Products. Remington's Pharmaceutical Sciences (Mack Printing Co., Easton, Pennsylvania), pp. 388.
9. KAWASHIYA, Y., 1986, Development of Agglomerated Crystallization Technique Using New Agglomeration Phenomena of Particles in Liquid System and Particle Designs for Pharmaceutical Preparations. Yukugaku Zasshi, 106(6), 433-445.
10. KAWASHIMA, Y., IWAMOTO, T., NIWA, T., TAKEUCHI, H., and ITOH, Y., 1991, Preparation and characterization of a new controlled release Ibuprofen Suspension for Improving Suspendability. International of Journal of Pharmaceutics, 75, 25-36.
11. LAW, S. L., and KAYES, J. B., 1983, Adsorption of non-ionic water soluble cellulose polymers at the solid-water interface and their effect on suspension stability. International Journal of Pharmaceutics, 15, 251-260.
12. LAW, S. L., and KAYES, J. B., 1984, Stability of suspensions in the presence of non-ionic water soluble cellulose polymers. Drug Development and Industrial Pharmacy, 10(7), 1049-1069 (1984).
13. LAW, S. L., 1988, Rheometric studies of ibuprofen suspensions in the presence of hydroxyethyl cellulose polymers. Chung-hua Yao Hsueh Tsa Chih, 40(4), 253-257.
14. MORRISON, R. T., and BOYD, R. N., 1971, Organic Chemistry (Allyn and Bacon Inc., Boston), pp. 630-633.
15. TSAO, J. C., and SAVAGE, T. S., 1985, High-performance liquid chromatographic determination of ibuprofen in bulk drug and tablets, Drug Development and Industrial Pharmacy, 5, 1123-1131.