Thymocyte development in vitro: Implications for studies of ageing and thymic involution

Mechanisms of Ageing and Development

Volumn 93, Issue 1-3, 1997, Pages 47-57

  Montecino Rodriguez, Encarnacion ^a   Dorshkind, Kenneth ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ageing; Culture systems; Thymopoiesis

Indexed keywords

AGING; CONFERENCE PAPER; IMMUNE DEFICIENCY; INVOLUTION; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

AGING; ANIMALS; BONE MARROW; CELL DIFFERENTIATION; HEMATOPOIETIC STEM CELLS; HUMANS; LIVER; MICE; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0030888079     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01818-0     Document Type: Conference Paper

References (63)

1. R. Miller, The aging immune system: primer and prospectus. Science, 273 (1996) 70-74.
2. K. Hirokawa, Understanding the mechanism of the age-related decline of the immune function. Nutr. Rev., 50 (1992) 361-366.
3. M. Thoman, D. Ernst, M. Hobbs and W. Weigle, T cell differentiation and functional maturation in aging mice. Adv. Exp. Med. Biol., 330 (1990) 93-118.
4. G. Steinmann, Changes in the human thymus during aging, In Current Topics in Pathology, 75, Springer Verlag, Berlin, 1986, pp 43-88.
5. J. Owen and E. Jenkinson, Early events in T lymphocyte genesis in the fetal thymus. Am. J. Anat., 170 (1984) 301-310.
6. J. Kurtzberg, S. Denning, L. Nycum, K. Singer and B. Haynes, Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells. Proc. Natl. Acad. Sci. USA, 86 (1989) 7575-7579.
7. B. Fowlkes and D. Pardoll, Molecular and cellular events of T cell development. Adv. Immunol., 44 (1989) 207-264.
8. E. Donskoy and I. Goldschneider, Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice. J. Immunol., 148 (1992) 1604-1612.
9. E. Rothenberg, The development of functionally responsive T cells. Adv. Immunol., 51 (1992) 85-214.
10. B. Haynes, S. Denning, P. Le and K. Singer, Human intrathymic T cell differentiation. Semin. Immunol., 2 (1990) 67-77.
11. B. Adkins, C. Mueller, C. Okada, R. Reichert, I. Weissman and G. Spangrude, Early events in T-cell maturation. Annu. Rev. Immunol., 5 (1987) 325-365.
12. M. Pearse, L. Wu, M. Egerton, A. Wilson, K. Shortman and R. Scollay, A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. Proc. Natl. Acad. Sci. USA, 86 (1989) 1614-1618.
13. D. Godfrey and A. Zlotnik, Control points in early T-cell development. Immunol Today, 14 (1993) 547-553.
14. E. Jenkinson, W. van EwiJk and J. Owen, Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J. Exp. Med., 153 (1981) 280-292.
15. P. Hugo, J. Kappler, D. Godfrey and P. Marrack, A cell line that can induce positive selection. Nature, 360 (1992) 679-682.
16. H. von Boehmer, Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol., 8 (1990) 531-556.
17. G. Anderson, E. Jenkinson, N. Moore and J. Owen, MHC class II-positive epithelium and mesenchyme cells are both required for T cell development in the thymus. Nature, 362 (1993) 70-73.
18. R.L. Boyd, C.L. Tucek, D.I. Godfrey et al., The thymic microenvironment. Immunol. Today, 14 (1993) 445-459.
19. W. van Ewijk, T-cell differentiation is influenced by thymic microenvironments. Annu. Rev. Immunol., 9 (1991) 591-616.
20. E.J. Jenkinson and J.J.T. Owen, T cell differentiation in thymus organ cultures. Semin. Immunol., 16 (1990) 12-19.
21. J.C. Zuniga-Pflucker, D. Jiang and M.J. Lenardo, Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation. Science, 268 (1995) 1906-1909.
22. E.J. Jenkinson, G. Anderson and J.J.T. Owen, Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med., 176 (1992) 845-853.
23. M. Papiernik, B. Nabarra, W. Savino, C. Pontoux and S. Barbey, Thymic reticulum in mice. III. Culture and characterization of nonepithelial phagocytic cells of the thymic reticulum: their role in the syngeneic stimulation of thymic medullary lymphocytes. Eur. J. Immunol., 13 (1983) 147-155.
24. T.-T. Sun, P. Bonitz and W. Burns, Cell culture of mammalian thymic epithelial cells: growth, structural, and antigenic properties. Cell. Immunol., 83 (1984) 1-13.
25. T. Itoh, H. Doi, S. Chin, T. Nishimura and S. Kasahara, Establishment of mouse thymic nurse cell clones from a spontaneous BALB/c thymic tumor. Eur. J. Immunol., 18 (1988) 821-824.
26. G. Anderson, N.C. Moore, J.J.T. Owen and E.J. Jenkinson, Cellular interactions in thymocyte development. Annu. Rev. Immunol., 14 (1996) 73-99.
27. R. Boyd and P. Hugo, Towards an integrated view of thymopoiesis. Immunol. Today, 12 (1991) 71-79.
28. P. Le, J. Kurtzberg, S. Brandt, J. Niedel, B. Haynes and K. Singer, Human thymic epithelial cells produce granulocyte and macrophage stimulating factors. J. Immunol., 141 (1988) 1211-1217.
29. J. Ramson, M. Fisher, L. Mercer and A. Zlotnik, Lymphokine-mediated induction of antigen-presenting ability in thymic stromal cells. J. Immunol., 139 (1987) 2620-2628.
30. S. Denning, D. Tuck, K. Singer and B. Haynes, Human thymic epithelial cells function as accessory cells for autologous mature thymocytes activation. J. Immunol., 138 (1987) 680-686.
31. S. Faas, J. L. Rothstein, B. Kreider, G. Rovera and B. Knowles, Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells. Eur. J. Immunol., 23 (1993) 1201-1014.
32. S. Carding, A. Hayday and K. Bottomly, Cytokines in T cell development. Immunol. Today, 12 (1991) 239-245.
33. K. Dorshkind, Regulation of hematopoiesis by bone marrow stromal cells and their products. Annu. Rev. Immunol., 8 (1990) 111-137.
34. P. Kincade, G. Lee, C. Pietrangeli, S.-I. Hayashi and J. Gimble, Cells and molecules that regulate B lymphopoiesis in bone marrow. Annu. Rev. Immunol., 7 (1989) 111-143.
35. A. Namen, S. Lupton, K. Hjerrilk et al., Stimulation of B cell progenitors by clonal murine Interleukin-7. Nature, 333 (1988) 571-573.
36. G. Lee, A. Namen, S. Gillis, L. Ellingsworth and P. Kincade, Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-β. J. Immunol., 142 (1989) 3875-3883.
37. J. Watson, P. Morrissey, A. Namen, P. Conlon and M. Widmer, Effect of IL-7 on the growth of fetal thymocytes in culture. J. Immunol., 143 (1989) 1215-1222.
38. R. Murray, T. Suda, N. Wrighton, F. Lee and A. Zlotnik, IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int. Immunol., 1 (1989) 526-531.
39. D. Lobach and B. Haynes, Ontogeny of the human thymus during fetal development. J. Clin. Immunol., 107 (1987) 129-134.
40. L. Lu, D. Walker, H. Broxmeyer, R. Hoffman, W. Hu and E. Walker, Characterization of adult human marrow hematopoietic progenitors highly enriched by two color cell sorting with My 10 and major histocompatibilty class II monoclonal antibodies. J. Immunol., 139 (1987) 1823-1829.
41. + marrow cells engraft lethally irradiated baboons. J. Clin. Invest., 81 (1988) 951-955.
42. R. Namikawa, K. Weilbaecher, H. Kaneshima, E. Yee and J. McCune, Long-term hematopoiesis in the SCID-hu mouse. J. Exp. Med., 172 (1990) 1055-1063.
43. S. Denning, J. Kurtzberg, D. Leslie and B. Haynes, Human postnatal CD4' CDS-CDS'thymic T cell precursors differentiate in vitro into T cell receptor 'delta'-bearing cells. J. Immunol., 142 (1989) 2988-2997.
44. + bone marrow cells. J. Exp. Med., 177 (1993) 1531-1539.
45. + cells in vitro. Nature Med., 2 (1996) 46-51.
46. S. Ezine, I. Weissman and R. Rouse, Bone marrow cells give rise to distinct clones within the thymus. Nature, 309 (1984) 629-631.
47. + precursor cells. J. Exp. Med., 174 (1991) 1283-1286.
48. + into more mature stages induced by a thymic stromal cell clone. Proc. Nat. Acad. Sci. USA, 87 (1990) 2750-2754.
49. - thymocytes by synergy with phorbol myristate acetate or various IL. J. Immunol., 142 (1989) 1195-1202.
50. - thymocytes in short-term thymic stromal cell culture. J. Exp. Med., 176 (1992) 543-551.
51. A. Wilson, H. Petrie, R. Scollay and K. Shortman, The acquisition of CD4 and CDS during the differentiation of early thymocytes in short-term culture. Int. Immunol., 1 (1989) 605-612.
52. H. Petrie, P. Hugo, R. Scollay and K. Shortman, Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CDS acquisition in vivo and in vitro. J. Exp. Med., 172 (1990) 1583-1588.
53. + precursors. Proc. Nat. Acad. Sci. USA, 86 (1989) 7542-7546.
54. M. Tamir, R. Eren, A. Globerson et al., Selective accumulation of lymphocytes precursor cells mediated by stromal cells of hemopoietic origin. Exp. Hematol., 18 (1990) 332-340.
55. E. Montecino-Rodriguez and K. Dorshkind, Long-term culture of triple negative thymocytes. J. Immunol., 156 (1996) 957-962.
56. L. Wu, M. Antica, G. Johnson, R. Scollay and K. Shortman, Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med., 174 (1991) 1617-1627.
57. E. Montecino-Rodriguez, A. Johnson and K. Dorshkind, Thymic stromal cells can support B cell differentiation from intrathymic precursors. J. Immunol., 156 (1996) 963-967.
58. A. Sharp, T. Kukulansky and A. Globerson, In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors. Eur. J. Immunol., 20 (1990) 2541-2546.
59. K. Hirokawa, S. Kubo, M. Utsuyama, C. Kurashima and T. Sado, Age related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell. Immunol., 100 (1986) 443-451.
60. A. Globerson, A. Sharp, M. Fridkis-Hareli et al., Aging in the T lymphocyte compartment. A developmental view. Ann. NY Acad. Sci., 673 (1992) 240-251.
61. M. Sawada, J. Namamine, K. Takeda et al., Expression of VLA-4 on thymocytes maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells. J. Immunol., 149 (1992) 3517-3524.
62. D. Dunai and B.A. Imhof, Mechanisms of thymus homing. Blood, 81 (1993) 1-8.
63. L. Wu, P.W. Kincade and K. Shortman, The CD44 expression on the earliest extra-thymic precursor population functions as a thymic homing molecule but does not bind to hyaluronate. Immunol. Lett., 38 (1993) 60-75.